Mass spectrometric analysis of head-to-tail connected cyclic peptides

• Autorzy: Macht M. , Pelzing M. , Palloch P. , Sauerland V. , Volz J.
• Języki publikacji: EN

Abstrakty

EN

Tandem mass spectrometry is an extremly useful tool for high sensitive sequence identification of peptides. In the case of cyclic peptides fragmentation can easily be performed for sequence analysis. However, analysis is usually tedious due to the lack of a defined beginning and end of the sequence. Since cyclic peptides are a highly in­teresting class of compounds especially for the pharmaceutical industry, ways have to be found to identify their structures. In this work we demonstrate how software and dedicated analytical strategies can be used for detailed analysis of these substances.

Słowa kluczowe

EN

pharmaceutical industry; peptide; mass spectrometry; cyclic peptide; identification; peptide sequencing

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.1109-1112,fig.

Twórcy

autor

Macht M.

• Bruker Saxonia Analytik, Leipzig, Germany

autor

Pelzing M.

autor

Palloch P.

autor

Sauerland V.

autor

Volz J.

Bibliografia

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