Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives

• Autorzy: Kazimierczuk Z. , Upcroft J.A. , Upcroft P. , Gorska A. , Starosciak B. , Laudy A.
• Języki publikacji: EN

Abstrakty

EN

Two series of benzimidazole derivatives were sythesised. The first one was based on 5,6-dinitrobenzimidazole, the second one comprises 2-thioalkyl- and thioaryl-sub- stituted modified benzimidazoles. Antibacterial and antiprotozoal activity of the newly obtained compounds was studied. Some thioalkyl derivatives showed remark­able activity against nosocomial strains of Stenotrophomonas malthophilia, and an ac­tivity comparable to that of metronidazole against Gram-positive and Gram-negative bacteria. Of the tested compounds, 5,6-dichloro-2-(4-nitrobenzylthio)-benzimidazole showed the most distinct antiprotozoal activity.

Słowa kluczowe

EN

Stenotrophomonas malthophilia; antiprotozoal activity; 5,6-dichlorobenzimidazole-1-beta-D-ribofuranoside; antibacterial activity; benzimidazole

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 1
• Opis fizyczny: p.185-195

Twórcy

autor

Kazimierczuk Z.

• Agricultural University, Warsaw, Poland

autor

Upcroft J.A.

autor

Upcroft P.

autor

Gorska A.

autor

Starosciak B.

autor

Laudy A.

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