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2006 | 15 | 2 |

Tytuł artykułu

Relations between the polymorphism in the coding and 5'-flanking regions of the porcine MYOD1 and MYF5 genes and productive traits in pigs

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The MyoD family genes were considered as candidate genes for growth rate and carcass meatiness in pigs. Gene mutations (SNPs, single nucleotide polymorphisms) discovered in the coding and 5’-flanking regions of the MYOD1 and MYF5 were analysed as possible causal mutations for these traits. Studies of the relation between polymorphisms in both those genes and productive traits were performed on Polish Landrace and Polish Large White gilts. A total of 401 animals (185 Polish Large White and 216 Polish Landrace) was encompassed by the analyses. Homozygotes of the “wild” allele as regards all three mutations of the MYOD1 taken into consideration in the present study appeared to be more profitable for traits characterizing carcass meatiness than the two remaining genotypes. In turn, heterozygotes for mutations identified in the MYF5 gene proved to be most favourable in terms of carcass meatiness. The effect of MyoD genotypes on performance traits was observed to be similar irrespective of the animals’ breed. This may suggest that new mutations, identified in the coding and 5’-flanking regions of MYOD1 and MYF5 genes, could be more useful for selection than the earlier known mutations in the non-coding regions of these genes. In our opinion, two mutations identified in exon 1 of the MYOD1 gene could be most beneficial and useful in selection and breeding of pigs.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

15

Numer

2

Opis fizyczny

p.225-235,ref.

Twórcy

autor
  • Polish Academy of Sciences, Jastrzebiec, 05-552 Wolka Kosowska, Poland
autor
autor
autor

Bibliografia

  • Cieślak D., Kapelański W., Blicharski T., Pierzchała M., 2000. Restriction fragment length polymorphism in myogenin and myf-3 genes and their influence on lean meat content in pigs. J. Anim. Breed. Genet. 117, 43-55
  • Cieślak D., Kurył J., Kapelański W., Pierzchała M., Grajewska S., Bocian M., 2002. A relationship between genotypes at MYOG, MYF3 and MYF5 loci and carcass meat and fat deposition traits in pigs. Anim. Sci. Pap. Rep. 20, 77-92
  • Comings D.E., MacMurray J.P., 2000. Molecular heterosis: a review. Mol. Genet. Metab. 71, 19-31
  • Kablar B., Krastel K., Ying Ch., Asakura A., Tapscott S.J., Rudnicki M.A., 1997. MyoD and Myf-5 differetially regulate the development of limb versus trunk skeletal muscle. Development 124, 4729-4738
  • Kamiński S., Wójcik E., Ruść A., Brym P., 2001. The frequency of alleles in locus RYR1 in important boars breeds with region Warmia and Mazury. XIVth Congress Polish Society of Genetics, Poznań, Abstracts, p. 55
  • Kawasaki E.S., 1990. Sample preparation from blood, cells and other fluids. In: M.A.Innis, D.H.Gelfand, J.J.Sninsky, T.J.White (Editors). PCR Protocols: A Guide to Methods and Applications. Academic Press, New York, pp. 3-12
  • Koishi K.M., Zhang M., McLennan I.S., Harris A.J., 1995. MyoD protein accumulates in satellite cells and is neurally regulated in regenerating myotubes and skeletal muscle fibres. Develop. Dynam. 202, 244-254
  • Kurył J., Kapelański W., Cieślak D., Pierzchała M., Grajewska S., Bocian M., 2002. Are polymorphisms in non-coding regions of porcine MyoD genes suitable for predicting meat and fat deposition in the carcass. Anim. Sci. Pap. Rep. 20, 245-254
  • Lee S.S., Chen Y., Moarn C., Stratil A., Reiner G., Bartenschlager H., Moser G., Geldermann H., 2003. Linkage and QTL mapping for Sus scrofa chromosome 5. J. Anim. Breed. Genet. 120, Suppl. 1, 38-44
  • Megeney L.A., Kablar B., Garrett K., Anderson J.E., Rudnicki M.A., 1996. MyoD is required for myogenic stem cell function in adult skeletal muscle. Gene Develop. 10, 1173 -1183
  • Różycki M., 1996. Procedures applied at slaughter performance testing stations. Report on Pig Breeding in Poland. National Research Institute of Animal Production. Kraków, pp. 69-82
  • SAS Institute, 2002. SAS/STAT User’s Guide, version 8.2, SAS Institute Inc., Cary, NC te Pas M.F.W., Harders F.L., Soumillion A., Born L., Buist W., Meuwissen T.H.E., 1999. Genetic variation at the porcine MYF5 gene locus. Lack of association with meat production traits. Mamm. Genome 10, 123-127
  • te Pas M.F.W., Visscher A.H., 1994. Genetic regulation of meat production by embryonic muscle formation - a review. J. Anim. Breed. Genet. 111, 404-412
  • Urbański P., Kurył J., 2004a. Two new SNPs within exon 1 of the porcine MYOD1 (MYF3) gene and their frequencies in chosen pig breeds and lines. J. Anim. Breed. Genet. 121, 204-208
  • Urbański P., Kurył J., 2004b. New SNPs in the coding region and 5’ flanking regions of the porcine MYOD1 (MYF3) and MYF5 genes. J. Appl. Genet. 45, 325-329
  • Weber E., 1986. Grundriss der biologischen Statistik. VEB Gustav Fischer Verlag, Jena, pp. 181-184
  • Weintraub H., 1993. The MyoD family and myogenesis: redundancy, networks and thresholds. Cell 75, 1241-1244

Typ dokumentu

Bibliografia

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