Oxygen breathing and ventilation

• Autorzy: Marczak M. , Pokorski M.
• Języki publikacji: EN

Abstrakty

EN

We investigated the ventilatory response to normobaric poikilocapnic hyperoxia in healthy subjects. The study was carried out in 26 subjects of the mean age 26 ±0.9 (SE) years, who breathed pure oxygen through a two-way valVE for 10 min. The subjects were in the sitting position with a mouthpiece and nose clip attached. Ventilatory flow was recorded using a pneumotachograph and minute ventilation was calculated from the tidal and frequency components. The SaO2 and alveolar CO2 tension were continuously monitored. Ten of the same subjects constituted a control group in which room air was substituted for oxygen and the tests repeated in the same way at another occasion. We found that oxygen breathing caused a transient 8.4% decline in ventilation, whose nadir was 1 min after the introduction of oxygen. Thereafter, ventilation increased significantly aboVE the baseline value and showed a further rising tendency toward the end of the test. We conclude that acute oxygen treatment is unlikely to haVE a major inhibitory effect on the carotid body-dependent ventilatory driVE in normal subjects. The determinants of the hyperoxic ventilatory stimulation remain to be established in further studies.

Słowa kluczowe

EN

ventilation; respiratory pattern; hyperoxia; oxygen

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2004
• Tom: 55
• Numer: 1,1
• Opis fizyczny: p.127-134,fig.,ref.

Twórcy

autor

Marczak M.

• Polish Academy of Sciences, 5, Pawinskiego St., 02-106 Warsaw, Poland

autor

Pokorski M.