Fibroblast cell shape and adhesion in vitro is altered by overexpression of the 7A and 7B isoforms of protocadherin 7, but not the 7C isoform

• Autorzy: Yoshida K
• Języki publikacji: EN

Abstrakty

EN

Protocadherins (Pcdhs) are a family of cadherins considered to play an important role in the cell-cell adhesion of specific neurons in the central nervous system. Of the reported Pcdhs, relatively little is known about the functional role of protocadherin 7 (Pcdh7), and there is no evidence of Pcdh7 mediated cell-cell adhesion. To date, three splicing variants are known; they may have different effects on cell phenotype. We report here that mouse fibroblast L cells stably overexpressing the Pcdh7 isoforms 7a and 7b, but not 7c, showed a morphological change and Ca2+ dependent cell adhesion.

Słowa kluczowe

EN

adhesion; brain; cadherin; fibroblast cell; isoform; protocadherin 7; in vitro; central nervous system; cell adhesion; overexpression

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2003
• Tom: 08
• Numer: 3
• Opis fizyczny: p.735-741,fig.

Twórcy

autor

Yoshida K

• University of Tokyo, 4-6-1- Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

Bibliografia

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