Conformational analysis of a novel cyclic enkephalin analogue using NMR and EDMC calculations

• Autorzy: Sidor M. , Wojcik J. , Pawlak D. , Izdebski J.
• Języki publikacji: EN

Abstrakty

EN

Conformational space of a novel cyclic enkephalin analogue, cyclo(Nε, Nε'-carbonyl-D-Lys2,Lys5) enkephalinamide, was exhaustively examined. A large number of conformations was selected and clustered into families on the basis of their structure and energy. For representative conformations ROESY spectra were generated and their linear combination was fitted to the spectra measured in water and Me2-SO-d6. This procedure yielded an ensemble of most populated conformations of the peptide in the two solvents.

Słowa kluczowe

EN

receptor specificity; enkephalin sequence; opioid peptide; enkephalin; peptide activity

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1999
• Tom: 46
• Numer: 3
• Opis fizyczny: p.641-650,fig.

Twórcy

autor

Sidor M.

• Polish Academy of Sciences, A.Pawinskiego 5a, 02-106 Warsaw, Poland

autor

Wojcik J.

autor

Pawlak D.

autor

Izdebski J.

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