Tumors and the danger model

• Autorzy: Kowalczyk D. W.
• Języki publikacji: EN

Abstrakty

EN

This article reviews the evidence for the danger model in the context of immune re­sponse to tumors and the insufficiency of the immune system to eliminate tumor growth. Despite their potential immunogenicity tumors do not induce significant immune re­sponses which could destroy malignant cells. According to the danger model, the im­mune surveillance system fails to detect tumor antigens because transformed cells do not send any danger signals which could activate dendritic cells and initiate an im­mune response. Instead, tumor cells or antigen presenting cells turn off the respond­ing T cells and induce tolerance. The studies reviewed herein based on model tumor antigens, recombinant viral vec­tors and detection of tumor specific T cells by MHC/peptide tetramers underscore the critical role of tumor antigen presentation and the context in which it occurs. They in­dicate that antigen presentation only by activated but not by cancer or resting den­dritic cells is necessary for the induction of immune responses to tumor antigens. It becomes apparent that the inability of dendritic cells to become activated provides a biological niche for tumor escape from immune destruction and seems to be a princi­pal mechanism for the failure of tumor immune surveillance.

Słowa kluczowe

EN

antigen; dendritic cell; immune system; heat shock protein; tumour; cancer; T cell; immune response

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 2
• Opis fizyczny: p.295-302,fig.

Twórcy

autor

Kowalczyk D. W.

• K.Marcinkowski University School of Medical Sciences, Garbary 15, 61-866 Poznan, Poland

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