The effect of alpha-tocopherol in the acute ethanol intake and its withdrawal on penicillin-induced epilepsy

• Autorzy: Kozan R , Ayyildiz M. , Yildirim M. , Agar E.
• Języki publikacji: EN

Abstrakty

EN

The present study was designed to investigate the influence of acute ethanol intake and its withdrawal on the anticonvulsant effect of alpha-tocopherol in penicillin-induced epileptiform activity. Ethanol-treated rats received a daily dose of 3 g/kg or 9.0 g/kg of 30% ethanol solution for 3 days. Thirty minutes after penicillin injection (500 units, i.c.), the most effective dose of alpha-tocopherol (500 mg/kg) was administered intramuscularly (i.m.). Acute administration of ethanol, in a dose of 3 g/kg, did not change either frequency or amplitude of penicillin-induced epileptiform activity, while dose of 9 g/kg ethanol significantly decreased the mean frequency of penicillin-induced epileptiform ECoG activity in the ethanol-treated group. Ethanol (9 g/kg) withdrawal also caused an increase in the amplitude of epileptiform ECoG activity in the withdrawal group. The results suggest that acute administration of high dose ethanol (9 g/kg) and alpha-tocopherol have some limited anticonvulsive effects in penicillin-induced epileptiform activity in rats.

Słowa kluczowe

EN

anticonvulsant effect; alpha-tocopherol; penicillin-induced epilepsy; acute ethanol intake; ethanol; psychoactive drug; gene expression; electrophysiology

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 2
• Opis fizyczny: p.177-188,fig.,ref.

Twórcy

autor

Kozan R

• University of Ondokuz Mayis, 55139 Samsun, Turkey

autor

Ayyildiz M.

autor

Yildirim M.

autor

Agar E.

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