Stucture-activity relationships for phosphorylation of nucleoside analogs to monophosphates by nucleoside kinases

• Autorzy: Johansson N. G. , Eriksson S.
• Języki publikacji: EN

Abstrakty

EN

The mammalian deoxyribonucleoside kinases thymidine kinase 1 and 2, deoxy- cytidine kinase and deoxyguanosine kinase phosphorylate deoxyribonucleosides and provide an alternative to de novo synthesis of DNA precursors. Their activities are essential for activation of several chemotherapeutically important nucleoside analogs. These four salvage kinase enzymes exhibit distinct substrate specificities for nucleoside analogs modified in the base and glycon moieties. In this review their, structure-activity relationships are discussed. Alternative routes for phosphorylation of nucleoside analogs are also reviewed, such as the phosphotransfer capacity of 5'-nucleotidase and protein kinases.

Słowa kluczowe

EN

nucleoside kinase; DNA precursor; phosphorylation; activity relationship; salvage kinase enzyme; nucleotidase; deoxynucleoside kinase; monophosphate; protein kinase

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1996
• Tom: 43
• Numer: 1
• Opis fizyczny: p.143-160

Twórcy

autor

Johansson N. G.

• Medivir AB, Lunastigen 7, S-141 44 Huddinge, Sweden

autor

Eriksson S.

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