Influence of ethanol on the activity of glycosidases in rats exposed to cadmium [Cd2]

• Autorzy: Arciuch L. P. , Omasta A. , Rostkowska K. , Galazyn-Sidorczuk M. , Moniuszko-Jakoniuk J. , Zwierz K.
• Języki publikacji: EN

Abstrakty

EN

Inhibition by ethanol of the activities of lysosomal exoglycosidases in stomach, small intestine, liver and brain of rats exposed to cadmium (Ca ) was determined. Out of the glycosidases tested the most distinct effect of Cd2+ and ethanol administered to the rats in vivo was observed in the small intestinal mucosa in a decreasing orden N-acetyl-^-hexosaminidase, p-galactosidase and a-fucosidase.

Słowa kluczowe

EN

ethanol; brain; cadmium; liver; rat; glycosidase; heavy metal

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1995
• Tom: 42
• Numer: 3
• Opis fizyczny: p.297-299,fig.

Twórcy

autor

Arciuch L. P.

• Medical Academy in Bialystok, A.Mickiewicza 2a, 15-222 Bialystok 8, Poland

autor

Omasta A.

autor

Rostkowska K.

autor

Galazyn-Sidorczuk M.

autor

Moniuszko-Jakoniuk J.

autor

Zwierz K.

Bibliografia

• 1. Yost, K.J. (1984) Cadmium, the environment and human health: an overview. Experientia 40,157- -164.
• 2. Bernard, A., Lauwerys, R. & Ouled-Amor, A. (1992) Loss of glomerular polyanion correlated with albuminuria in experimental cadmium nephropathy. Arch. Toxicol. 66,272-278.
• 3. Scott, M.C. & Chettle, D.R. (1986) In vivo ele­mental analysis in occupational medicine. Scand. /. Work. Environ. Health 12, 86-91.
• 4. Lieber, C.S. (1988) Metabolic effects of acetal- dehyde. Biochem. Soc. Trans. 16,241-247.
• 5. Lieber, C.S. (1988) Biochemical and molecular basis of alcohol-induced injury to liver and other tissues. N. Engl. J. Med. 319,1639-1650.
• 6. Ostrovsky, Y.M. (1986) Endogenous ethanol — its metabolic, behavioral and biomedical signi­ficance. Alcohol 3,239-247.
• 7. Lindros, K.O. (1978) Acetaldehyde — its metabolism and role in the action of alcohol; in Research Advances in Alcohol and Drug Problems (Israel, Y. et ah, eds.) vol. 4, pp. 111-176, Plenum Publishing Corporation, New York.
• 8. Chatteriee, S., Velicer, L.F. & Sweeley, C.C. (1975) Glycosphingolipid glycosyl hydrolases and glycosidases of synchronized human KB cells. J. Biol. Chem. 250,4972-4979.
• 9. Zwierz, K., Gindzieriski, A., Glowacka, D. & Porowski, T. (1981) The degradation of glyco­conjugates in the human gastric mucous membrane. Acta Med. Acad. Sci. Hung. 38, 145-152.
• 10. Lowry, O.H., Rosebrough, N.J., Farr, A.L. & Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. /. Biol. Chem. 193, 265-275.
• 11. Gozdzik, T., Grzybek, H. & Panz, B. (1984) Pathological changes in human organism during acute and chronic intoxication with cadmium. Wiad. Lek. 37,199-203 (in Polish)