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2006 | 15 | 4 |

Tytuł artykułu

Local transfer of substances between the blood vessels at the base of the brain

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Studies performed on a variety of species (pigs, sheep, rabbits, rats) indicate the existence of a local transfer system of substances between blood vessels located at the base of the cranium (the cavernous sinus - carotid artery vascular complex). This local transfer allows for some hormones synthesized in the brain and hypophysis, as well as biologically active substances absorbed from the nasal mucosa, and drained to the cavernous sinus to reach the brain vasculature in a concentration locally higher than that measured in systemic circulation. The present paper gives an overview of: 1. the major anatomical structure engaged in the transfer, 2. experimental evidence for substance transfer in the vascular complex, 3. factors affecting the transfer and 4. possible physiological importance.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

15

Numer

4

Opis fizyczny

p.543-553,fig.,ref.

Twórcy

autor
  • Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland

Bibliografia

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  • Einer-Jensen N., Larsen L., Deprez S., Starns E., Schwartz S., 2001. Intranasal absorption of sumatriptan and naratriptan: no evidence of local transfer from the nasal cavities to the brain arterial blood in male rats. Biopharm. Drug Dispos. 22, 213-219
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  • Grzegorzewski W., Skipor J., Wąsowska B., Krzymowski T., 1995. Counter current transfer of oxytocin from the venous blood of the perihypophyseal cavernous sinus to the arterial blood of carotid rete supplying the hypophysis and brain depends on the phase of the estrous cycle in pigs. Biol. Reprod. 52, 39-144
  • Grzegorzewski W., Skipor J., Wąsowska B., Krzymowski T., 1997. Countercurrent transfer of 125ILHRH in the perihypophyseal cavernous sinus-carotid rete vascular complex, demonstrated on isolated pig heads perfused with autologous blood. Domest. Anim. Endocrinol. 14, 149-160
  • Krzymowski T., Grzegorzewski W., Stefańczyk-Krzymowska S., Skipor J., Wąsowska B., 1999. Humoral pathway for transfer of the boar pheromone, androstenol, from the nasal mucosa to the brain and hypophysis of gilts. Theriogenology 52, 1225-1240
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  • Skipor J., Bao S., Grzegorzewski W., Wąsowska B., Rao ChV., 1999. The inhibitory effect of hCG on counter current transfer of GnRH and the presence of LH/hCG receptors in the perihypophyseal cavernous sinus - carotid rete vascular complex of ewes. Theriogenology 51, 899-910
  • Skipor J., Grzegorzewski W., Einer-Jensen N., Wąsowska B., 2003. Local vascular pathway for progesterone transfer to the brain after nasal administration in gilts. Reprod. Biol. 3, 143-159
  • Skipor J., Grzegorzewski W., Krzymowski T., Einer-Jensen N., 2000. Local transfer of testosterone from the nasal mucosa to the carotid blood and the brain in the pig. Pol. J. Vet. Sci. 3, 19-22
  • Skipor J., Grzegorzewski W., Wąsowska B., Krzymowski T., 1997. Counter current transfer of β- endorphin in the perihypophyseal cavernous sinus - carotid rete complex of sheep. Exp. Clin. Endocrinol. Diabetes 105, 308-313
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  • Skipor J., Wąsowska B., Grzegorzewski W., Zezula-Szpyra A., Stefańczyk-Krzymowska S., Thiéry J.-C., 2001. Transfer of dopamine by counter current mechanism in ewe changes with endocrine stage. Biog. Amine. 16, 431-445
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  • Stefańczyk-Krzymowska S., Krzymowski T., Grzegorzewski W., Wąsowska B., Skipor J., 2000. Humoral pathway for local transfer of the priming pheromone androstenol from the nasal cavity to the brain and hypophysis in anaesthetized gilts. Exp. Physiol. 85, 801-809
  • Stefańczyk-Krzymowska S., Krzymowski T., Wąsowska B., Jana B., Słomiński J., 2003. Intramuscular injections of male pheromone 5 α-androstenol change the secretory ovarian function in gilts during sexual maturation. Reprod. Biol. 3, 241-257
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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-01e68971-8108-4a03-a2ef-5fb9bdf9a8b2
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