Enhanced microdialysis of neuropeptides

• Autorzy: Pettersson A. , Markides K. , Bergquist J.
• Języki publikacji: EN

Abstrakty

EN

An enhanced microdialysis method for neuropeptides is described and some prelimi­nary results of this novel approach are presented. The enhancement is achieved by adding a vehicle (solid support) to the perfusion fluid in order to increase the diffusion coefficient across the membrane and efficiently transport the analytes towards the de­tector. The microdialysis samples are desalted and then analyzed on an electrospray ionization orthogonal time-of-flight mass spectrometer. The preliminary results show major increase in signal when comparing this new approach of microdialysis with or­dinary microdialysis.

Słowa kluczowe

EN

microdialysis; small molecule; neuropeptide; nervous system; neurotransmitter

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.1117-1120,fig.

Twórcy

autor

Pettersson A.

• Uppsala University, Box 531, SE-75121 Uppsala, Sweden

autor

Markides K.

autor

Bergquist J.

Bibliografia

• 1.Ungerstedt, U. (1991) J. Intern. Med. 230, 365-373.
• 2.Davies, M.I. (1999) Anal. Chim. Acta 379, 227-249.