Many cases of pleuropneumonia were observed in pigs aged 3—4 months on an industrial farm. In order to determine an optimal procedure there was performed an experiment on three groups of pigs. Group one containing 654 young pigs aged 6 weeks was given amoxacillin for 7 days at a dose of 12 g per 100 l of water. A vaccine against pleuropneumonia was administered the second group of young pigs (660 animals). The third group (660 young pigs) was vaccinated between 8 and 11 weeks of life against pleuropneumonia and in the period between vaccinations amoxacillin was administered for 7 days at a rate of 25 g per 100 kg of feed. Each experimental group of animals was compared with a control group comprising a nearing number of animals. The best results were observed in the third group mortality of 2.6 per cent compared with 7.7 per cent of death in the control group; daily weight gains were at 7.7 per cent higher than those in controls.