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2015 | 18 | 2 |

Tytuł artykułu

Verapamil-L type voltage gated calcium channel inhibitor diminishes aggressive behavior in male Siamese fighting fish

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Verapamil is a L-type voltage gated calcium channels inhibitor (VGCCI), which is a highly prescribed drug used in the treatment of hypertension, angina pectoris, cardiac arrhythmia and cluster headaches. Its common use caused its appearance in water environment. VGCC inhibit epinephrine release and cause many neuro-hormonal changes influencing also fish behavior. Siamese fighting fish was chosen to study the influence of verapamil given to the water on the beginning of experiment in 3 different concentrations of 0 (control), 8 and 160 μg • L-1, on aggressive behavior in these fish. The experimental fish were placed in individual glass containers for 3 weeks and the mirror test was used. The highest concentration led to a significant modulation of fish behavior after 1 week and the lower dose caused statistically significant behavioral changes after 2 weeks of verapamil treatment. Siamese fighting fish males exposed to verapamil had longer latencies to the first chase - 12.6 s (8 μg- L-1 of verapamil) and 18.8 s (160 μg • L-1 of verapamil) compared to 5.6 s in the control group, decreased attack frequency and shorter duration of these attacks. The number of attacks within 10 min was decreased from 38.3 in the control group to 27.1 and 16.1, respectively. Also the total duration of these attacks decreased from 354.8 (control) to 326.4 (decrease statistically insignificant) and to 194.8 s in verapamil treated groups. It was shown, that even relatively low concentrations of verapamil in water may have adverse effects on fish and probably other living organisms.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

18

Numer

2

Opis fizyczny

p.401-406,ref.

Twórcy

autor
  • University of Veterinary Medicine JU-AU Center, Department of Animal Biotechnology, Hugon Kollataj Agricultural University in Krakow, Krakow, Poland
autor
  • Department of Physiological Sciences, Faculty of Veterinary Sciences, Warsaw University of Life Sciences, Nowoursynowska 159, 02-766 Warsaw, Poland
autor
  • Department o Animal Physiology and Endocrinology, Faculty of Animal Sciences, Hugon Kollataj Agricultural University in Krakow, Krakow, Poland
autor
  • Department of Physiological Sciences, Faculty of Veterinary Sciences, Warsaw University of Life Sciences, Nowoursynowska 159, 02-766 Warsaw, Poland

Bibliografia

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Typ dokumentu

Bibliografia

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