Effect of platycodin D on gastric motility, gastric emptying and gastrointestinal transit

• Autorzy: Kim T.-W. , Lim J.-H. , Lee H.-K. , Giorgi M. , Owen H. , Yun H.-I.
• Języki publikacji: EN

Abstrakty

EN

Diarrhea is a condition which causes malabsorption and dehydration. Recently, the anti-motility effect of several herbal compounds for the treatment of hypermotility-induced diarrhea has been studied. The root of Platycodon grandiflorum has been widely used in oriental medicine for the treatment of various chronic inflammatory diseases. The aim of the present study was to assess the effects of Platycodin D (PD), the major triterpene saponin in the root of P. grandiflorum, on gastrointestinal (GI) motility by assessing both gastric emptying (GE) and intestinal transit (IT) in mice with different treatment protocols. Mice were randomly allocated to 5 groups (n = 15/group) according to their treatment protocols (control, administered with antikinetics: atropine, dopamine, or with pro-kinetics: itoride, bethanechol) for each GE and IT test. Each group was subsequently divided into 3 subgroups (n = 5) pre-treated with different PD doses (0, 2.5, and 5 mg/kg). Pre-treatment with PD in the control treatment group of mice showed reduced GE and IT in a dose-dependent manner. At the maximum PD effect, GE and IT were reduced by 63% and 50%, respectively, compared with those in the normal control group. In the groups given atropine or dopamine, pre-treatment with PD further reduced GE and IT by 35% to 58%, respectively. The PD pre-treatment dramatically reduced the GI motility enhanced by itopride and bethanechol. On the whole, these results suggest that PD treatment might be beneficial in motility-induced diarrhea.

Słowa kluczowe

EN

platycodin D; saponin; gastric motility; gastric emptying; gastrointestinal transit; intestinal transit; diarrhea; herbal compound; treatment

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2014
• Tom: 70
• Numer: 01
• Opis fizyczny: p.38-41,fig.,ref.

Twórcy

autor

Kim T.-W.

• College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea

autor

Lim J.-H.

• Center for Nutraceutical and Pharmaceutical Materials, Myong Ji University, Yogin, South Korea

autor

Lee H.-K.

• College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea

autor

Giorgi M.

• Department of Veterinary Sciences, University of Pisa, Via Livornese (lato monte) 1, San Piero a Grado, Italy

autor

Owen H.

• School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, Queensland, 4343, Australia

autor

Yun H.-I.

• College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea

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