The effect of the type and amount of fat in diet on the composition of fatty acids in tissue lipids in experimental hypercholesterolaemia

• Autorzy: Ziemlanski S. , Budzynska-Topolowska J. , Rodkiewicz B.

Warianty tytułu

PL

Wpływ rodzaju i ilości tłuszczu diety na skład kwasów tłuszczowych lipidów tkankowych w doświadczalnej hipercholesterolemii

• Języki publikacji: EN

Abstrakty

EN

The efects were studied of the quality and amount of dietary fat on the pattern of fatty acids in the lipids of the serum and certain tissues (adipose fat, perirenal fat, liver, heart, testes) of guined pigs during experimentally induced hypercholesterolemia. During 12 weeks the animals received experimental diets containg 10% or 20% of energy from animal fats (butter, lard 2:3), sunflower oil or low-erucic rapeseed oil. Two control groups were chosen, receiving diets for animals without cholesterol or with 0.1% cholesterol added. The addition of cholesterol to the diet raised the content of the essential unsaturated fatty acids and polyunsaturated fatty acids in the adipose fat and hepatic lipids, and decreased their content in myocardial lipids. In testicular lipids changes were noted in the synthesis of long-chain polyunsaturated fatty acids. The addition of vegetable fats to the diet increased the content of linoleic acid in these tissues with a simultaneous decrease of arachidonic acid synthesis. It may be supposed that there is an upper range of arachidonic acid synthesis in the lipids of the studied tissues independent of dietary EFA and PUFA value.

PL

Oznaczano wpływ ilości i jakości tłuszczu na skład kwasów tłuszczowych lipidów surowicy krwi i wybranych tkanek (tłuszcz zapasowy, wątroba, serca, jądra) świnek morskich w warunkach doświadczalnej hipercholesterolemii. Zwierzętom podawano w ciągu 12 tygodni diety doświadczalne zawierające 10% i 20% energii z tłuszczu zwierzęcego (masło, smalec 2; 3), oleju słonecznikowego lub oleju rzepakowego bezerukowego. Zastosowano dwie grupy kontrolne otrzymujące diety hodowlane bez cholesterolu oraz z dodatkiem 0.1% cholesterolu. Stwierdzono, że dodatek cholesterolu do diety hodowlanej wywołuje wzrost zawartości NNKT i PUFA w tłuszczu zapasowym i lipidach wątroby, przy jednoczesnym spadku tych kwasów w lipidach serca. W lipidach jąder stwierdzono zmiany w sytezie długołańcuchowych wielonienasyconych kwasów tłuszczowych. Dodatek do diety tłuszczów roślinnych zwiększa zawartość kwasu linolowego w badanych tkankach, przy jednoczesnym hamowaniu syntezy kwasu arachidonowego. Można przypuszczać, że istnieje określony górny limit syntezy kwasu arachidonowego w lipidach badanych tkanek niezależnie od ilości NNKT i PUFA w diecie.

Słowa kluczowe

EN

dietary fatty acid; polyunsaturated fatty acid; linoleic acid; arachidonic acid; tissue lipid; hypercholesterolemia

• Wydawca: -
• Czasopismo: Żywienie Człowieka i Metabolizm
• Rocznik: 1991
• Tom: 18
• Numer: 4
• Opis fizyczny: p.279-300,ref.

Twórcy

autor

Ziemlanski S.

• Department of Nutrition Physiology and Biochemistry National Food and Nutrition Institute in Warsaw, Warsaw, Poland

autor

Budzynska-Topolowska J.

• Department of Nutrition Physiology and Biochemistry National Food and Nutrition Institute in Warsaw, Warsaw, Poland

autor

Rodkiewicz B.

• Department of Nutrition Physiology and Biochemistry National Food and Nutrition Institute in Warsaw, Warsaw, Poland

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