Overview of the structure-based nongenomic effects of the nuclear receptor RXRα

• Autorzy: Chen L. , Wu L. , Zhao Y. , Zhu L.
• Języki publikacji: EN

Abstrakty

EN

The nuclear receptor RXRα (retinoid X receptor-α) is a transcription factor that regulates the expression of multiple genes. Its non-genomic function is largely related to its structure, polymeric forms and modification. Previous research revealed that some non-genomic activity of RXRα occurs via formation of heterodimers with Nur77. RXRα–Nur77 heterodimers translocate from the nucleus to the mitochondria in response to certain apoptotic stimuli and this activity correlates with cell apoptosis. More recent studies revealed a significant role for truncated RXRα (tRXRα), which interacts with the p85α subunit of the PI3K/AKT signaling pathway, leading to enhanced activation of AKT and promoting cell growth in vitro and in animals. We recently reported on a series of NSAID sulindac analogs that can bind to tRXRα through a unique binding mechanism. We also identified one analog, K-80003, which can inhibit cancer cell growth by inducing tRXRα to form a tetramer, thus disrupting p85α–tRXRα interaction. This review analyzes the non-genomic effects of RXRα in normal and tumor cells, and discusses the functional differences based on RXRα protein structure (structure source: the RCSB Protein Data Bank).

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2018
• Tom: 23
• Opis fizyczny: p.1-13,fig.,ref.

Twórcy

autor

Chen L.

• Liqun Chen and Lingjuan Wu contributed equally to this work. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China

autor

Wu L.

• Liqun Chen and Lingjuan Wu contributed equally to this work. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China

autor

Zhao Y.

• Liqun Chen and Lingjuan Wu contributed equally to this work. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China

autor

Zhu L.

• Liqun Chen and Lingjuan Wu contributed equally to this work. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China

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Identyfikatory

DOI

10.1186/s11658-018-0103-3