Alcohol reverses depressive and pronociceptive effects of chronic stress in mice with enhanced activity of the opioid system

• Autorzy: Sacharczuk M. , Juszczak G. , Swiergiel A. H. , Jaszczak K. , Lipkowski A. W. , Sadowski B.
• Języki publikacji: EN

Abstrakty

EN

The role of the opioid system in mediating effects of alcoholism and stress in depression is far from clear. We studied, therefore, the effects of chronic mild stress (CMS) and alcohol drinking on depression-like behavior and nociception in lines of mice selected for high (HA) or low (LA) swim stress-induced analgesia. Compared to the LA mice, the HA animals display up-regulation of opioid receptor system function and depression-like behavior in tail suspension test (TST). We report now that alcohol reverses depressive and pronociceptive effect of CMS in HA mice. In contrast, in LA mice CMS does not affect nociception or behavior in TST and the animals are not susceptible to alcohol under CMS. The results suggest that opioid system activity may determine the effects of alcohol on behavior under stress and, therefore, link predispositions to depression and to alcoholism.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 4
• Opis fizyczny: p.459–468,fig.,ref.

Twórcy

autor

Sacharczuk M.

• Department of Molecular Cytogenetic, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Wolka Kosowska, Poland

autor

Juszczak G.

• Department of Animal Behaviour, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Wolka Kosowska, Poland

autor

Swiergiel A. H.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland
• Department of Pharmacology, Toxicology and Neuroscience, Shreveport, LA, USA

autor

Jaszczak K.

• Department of Molecular Cytogenetic, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Wolka Kosowska, Poland

autor

Lipkowski A. W.

• Neuropeptide Laboratory, M.Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Sadowski B.

• Department of Animal Behaviour, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Wolka Kosowska, Poland

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