The genetic background is responsible for response to natural reward

• Autorzy: Kubik J. , Solecki W. , Przewlocki R.
• Języki publikacji: EN

Abstrakty

EN

The increased inclination to natural rewards like food and sensation seeking have been associated with elevated drug intake in humans. We aimed to compare four inbred mouse strains with known different susceptibility to drug addiction in respect to response to natural rewards. In this study, we investigated four inbred strains C57Bl/6J, DBA/2J, SWR/J and 129P3/J in the selfadministration of food (SAF) and operant sensation seeking (OSS) models in three paradigms: (1) the fi xed ratio operant task (FR), (2) the progressive ratio operant task and (3) the concurrent choice operant task. No difference in response to reward in SAF FR paradigm was found among the studied strains. In contrast C57Bl/6J mice performed better then DBA/2J and 129P3/J strains in OSS paradigm while SWR mice did not react at all. In turn, the highest score of correct choice in SAF was observed in 129P3/J mice. The systemic administration of dopamine D1 receptor antagonist SCH 23390 or opioid receptor antagonists (naloxone or naltrexone) reduced the response to reward in the C57Bl/6J and DBA/2J mice. Our data suggest that genotype background is responsible for reward-seeking in SAF and OSS models with C57Bl/6J mice being the most responsive to the reward. We observed also that food as a reward has different motivational value than sensation seeking. Also our study indicates that opioid and dopaminergic systems may be involved in the response to natural rewards.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.356

Twórcy

autor

Kubik J.

• Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Solecki W.

• Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Przewlocki R.

• Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland