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2012 | 68 | 01 |

Tytuł artykułu

Wybrane czynniki podwzgórzowe integrujące rozród i kontrolę bilansu energetycznego u zwierząt

Autorzy

Warianty tytułu

EN
Selected hypothalamic factors integrating reproduction and energy balance control in animals

Języki publikacji

PL

Abstrakty

EN
Mammalian reproduction is the most energy-consuming biological process. However, chronic dietary energy deficits, as well as energy surpluses can impair reproductive capacity, including the ability to produce viable gametes, and interrupt pregnancy or lactation. Thus, there is no doubt that the mechanisms controlling energy balance are integrated with those that control reproduction. There is functional evidence for a crucial connection between those mechanisms in the gonadotropin-releasing hormone (GnRH) cells of the hypothalamus, which are part of the hypothalamo-pituitary-gonadal (HPG) axis. Recent research has shown that the multiple hypothalamic peptidergic systems responsible for the homeostatic control of energy balance are involved in signaling to GnRH neurons. This group includes neuropeptyd Y (NPY), melanin-concentrating hormone (MCH), proopiomelanocortin (POMC), as well as periphery factors, such as leptin, ghrelin and insulin. However, the discovery of kisspeptin and gonadotropin-inhibitory hormone (GnIH) sheds a new light on mechanisms by which reproductive activity is regulated, also in the context of diurnal and annual photoperiod-driven cycles of mammals’ energy requirements. Thus, it seems clear that those two peptides are very important in linking the processes of energy balance maintenance and reproduction.

Wydawca

-

Rocznik

Tom

68

Numer

01

Opis fizyczny

s.35-39,bibliogr.

Twórcy

autor
  • Katedra Hodowli Trzody Chlewnej i Małych Przeżuwaczy, Wydział Hodowli i Biologii Zwierząt, Uniwersytet Rolniczy w Krakowie, Al.Mickiewicza 24/28, 30-069 Kraków
autor

Bibliografia

  • 1.Berthoud H. R.: Multiple neural systems controlling food intake and body weight. Neurosci. Biobehav. Rev. 2002, 393-428.
  • 2.Castellano J. M., Bentsen A. H., Mikkelsen J. D., Tena-Sempere M.: Kisspeptins: bridging energy homeostasis and reproduction. Brain Res. 2010, 1364, 129-138.
  • 3.Clarke I. J., Qi Y., Sari I. P., Smith J. T.: Evidence that RF-amide related peptides are inhibitors of reproduction in mammals. Front. Neuroendocrinol. 2009a, 30, 371-378.
  • 4.Clarke I. J., Smith J. T., Caraty A., Goodman R. L., Lehman M. N.: Kisspeptin and seasonality in sheep. Peptides 2009b, 30, 154-163.
  • 5.Clarkson J., d'Anglemont de Tassigny X., Moreno A. S., Colledge W. H., Herbison A. E.: Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. J. Neurosci. 2008, 28, 8691-8697.
  • 6.Clarkson J., Herbison A. E.: Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons. Endocrinology 2006, 147, 5817-5825.
  • 7.Decourt C., Tillet Y., Caraty A., Franceschini I., Briant C.: Kisspeptin immunoreactive neurons in the equine hypothalamus: interactions with GnRH neuronal system. J. Chem. Neuroanat. 2008, 36, 131-137.
  • 8.Gibson E. M., Humber S. A., Jain S., Williams W. P. 3rd., Zhao S., Bentley G. E., Tsutsui K., Kriegsfeld L. J.: Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge. Endocrinology 2008, 149, 4958-4969.
  • 9.Hakansson M. L., Brown H., Ghilardi N., Skoda R. C., Meister B.: Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 1998, 18, 559-572.
  • 10.Johnson M. A., Tsutsui K., Fraley G. S.: Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat. Horm. Behav. 2007, 51, 171-180.
  • 11. Kriegsfeld L. J., Mei D. F., Bentley G. E., Ubuka T., Mason A. O., Inoue K., Ukena K., Tsutsui K., Silver R.: Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals. Proc. Natl. Acad. Sci. USA 2006, 103, 2410-2415.
  • 12.Lehman M. N., Merkley C. M., Coolen L. M., Goodman R. L.: Anatomy of the kisspeptin neural network in mammals. Brain Res. 2010, 1364, 90-102.
  • 13.Oakley A. E., Clifton D. K., Steiner R. A.: Kisspeptin signaling in the brain. Endocr. Rev. 2009, 30, 713-743.
  • 14.Price D. A., Greenberg M. J.: Structure of a molluscan cardioexcitatory neuropeptide. Science 1977, 197, 670-671.
  • 15.Ramaswamy S., Guerriero K. A., Gibbs R. B., Plant T. M.: Structural Interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy. Endocrinology 2008, 149, 4387-4395.
  • 16.Revel F. G., Saboureau M., Pevet P., Simonneaux V., Mikkelsen J. D.: RFamiderelated peptide gene is a melatonin-driven photoperiodic gene. Endocrinology 2008, 149, 902-912.
  • 17.Smith J. T., Clarke I. J.: Seasonal breeding as a neuroendocrine model for puberty in sheep. Mol. Cell Endocrinol. 2010, 324, 102-109.
  • 18.Smith J. T., Coolen L. M., Kriegsfeld L. J., Sari I. P., Jaafarzadehshirazi M. R., Maltby M., Bateman K., Goodman R. L., Tilbrook A. J., Ubuka T., Bentley G. E., Clarke I. J, Lehman M. N.: Variation in kisspeptin and RF-amide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology 2008, 149, 5770-5782.
  • 19.Tachibana T., Sato M., Takahashi H., Ukena K., Tsutsui K., Furuse M.: Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks. Brain Res. 2005, 1050, 94-100.
  • 20.Todman M. G., Han S. K., Herbison A. E.: Profiling neurotransmitter receptor expression in mouse gonadotropin-releasing hormone neurons using green fluorescent protein-promoter transgenics and microarrays. Neurosci. 2005, 132, 703-712.
  • 21.Tsutsui K., Bentley G. E., Bedecarrats G., Osugi T., Ubuka T., Kriegsfeld L. J.: Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function. Front Neuroendocrinol. 2010, 31, 284-295.
  • 22.Tsutsui K., Saigoh E., Ukena K., Teranishi H., Fujisawa Y., Kikuchi M., Ishii S., Sharp P. J.: A novel avian hypothalamic peptide inhibiting gonadotropin release. Biochem. Biophys. Res. Commun. 2000, 275, 661-667.
  • 23.Wagner G. C., Johnston J. D., Clarke I. J., Lincoln G. A., Hazlerigg D. G.: Redefining the limits of day length responsiveness in a seasonal mammal. Endocrinology 2008, 149, 32-39.
  • 24.Ward D. R., Dear F. M., Ward I. A., Anderson S. I., Spergel D. J., Smith P. A., Ebling F. J.: Innervation of gonadotropin-releasing hormone neurons by peptidergic neurons conveying circadian or energy balance information in the mouse. PLoS One 2009, 4, e5322.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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