MicroRNA function in synapse development and plasticity

• Autorzy: Schratt G.M.
• Języki publikacji: EN

Abstrakty

EN

The proper development of synapses in the mammalian central nervous system is critical for cognitive functions, and aberrations lead to neurological disorders, e.g., intellectual disability, autism and schizophrenia. We have recently identified miRNAs that are important during various stages of excitatory synapse development in hippocampal neurons, such as dendritic arborization and spine maturation. Our current research explores the mechanisms of activity-dependent regulation of these miRNAs at the level of transcription, processing and subcellular localization. Furthermore, we characterize the role of activity-dependent miRNA regulation in different forms of synaptic plasticity, as well as the implications for higher cognitive functions and homeostasis, using genetically modified mice. Potential links to the above mentioned neurological disorders will also be discussed.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.21

Twórcy

autor

Schratt G.M.

• Institute for Physiological Chemistry, University of Marburg, Marburg, Germany