Time-dependent model to mimic acetylcholine induced vasodilatation in arterial smooth muscle cells

• Autorzy: Sahrawat T.R. , Chatterjee D.
• Języki publikacji: EN

Abstrakty

EN

Computational approaches for spatial modeling of dynamics of the intercellular distribution of molecules can parse, simplify, classify and organize the spatiotemporal richness of any biochemical pathway and demonstrate its impact on the cells function by simply coupling it with the downstream effecters. One such online system biology modeling package is Virtual cell that provides a unique open source software and it’s used for making mathematical models to simulate the cytoplasmic control of molecule that interact to produce certain cellular behavior. In our present study, a spatial model for time dependent acetylcholine induced relaxation of vascular endothelial cells lining the lumen of blood vessel that regulate the contractility of the arteries was generated. The time-dependent action of neurotransmitter acetylcholine for total time period for 1 second was studied on the endothelial cell at an interval of every 0.05 seconds. Such time simulated spatial models may be useful for testing and developing new hypotheses, interpretation of results and understand the dynamic behavior of cells.

Słowa kluczowe

EN

computational modelling; endothelial cell; neurotransmitter acetylcholine; vasodilatation; arterial muscle; smooth muscle cell; biochemical parameter; time-dependent model

• Wydawca: -
• Czasopismo: International Letters of Natural Sciences
• Rocznik: 2016
• Tom: 52
• Opis fizyczny: p.60-66,fig.,ref.

Twórcy

autor

Sahrawat T.R.

• Centre for System Biology and Bioinformatics, UIEAST, Panjab University, Chandigarh, India

autor

Chatterjee D.

• Centre for System Biology and Bioinformatics, UIEAST, Panjab University, Chandigarh, India

Bibliografia

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• DOI References
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• [7] T. Münzel, H. Li, H. Mollnau, U. Hink, E. Matheis, M. Hartmann, M. Oelze, M. Skatchkov, A. Warnholtz, L. Duncker, T. Meinertz, U. Förstermann, Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability, Circ. Res. 86 (1) (2000). 10.1161/01.res.86.1.e7
• [8] R.F. Furchgott , J.V. Zawadzki, The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature 288 (1980) 373-6. 10.1038/288373a0
• [9] R.F. Furchgott, P.D. Cherry, J.V. Zawadzki, D. Jothianandan, Endothelial cells as mediators of vasodilation of arteries, J. Cardiovasc. Pharmacol. 6(2) (1984) S336-343. 10.1097/00005344-198406002-00008
• [10] Y. Hirooka, T. Imaizumi, T. Tagawa, M. Shiramoto, T. Endo, S. Ando, A. Takeshita, Effects of Larginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure, Circulation 90(2) (1984) 658-668. 10.1161/01.cir.90.2.658
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Identyfikatory

DOI

10.18052/www.scipress.com/ILNS.52.60