Clinical efficacy of nutraceutical diet for cats with clinical signs of cutaneus adverse food reaction (CAFR)

• Autorzy: Mazzeranghi F. , Zanotti C. , Di Cerbo A. , Verstegen J.P. , Coccoa R. , Guidetti G. , Canello S.
• Języki publikacji: EN

Abstrakty

EN

Food allergies and food intolerances are clinically difficult to discriminate. Most often, along with cutaneous adverse food reactions or CAFR, they are classified as adverse food reactions, whose causes are numerous, including toxic compounds. Eighteen indoor-housed domestic cats with evident clinical symptoms related to CAFR (drooling, back and neck intense itching, neck eczema, chronic conjunctivitis and stomatitis) involving skin lesions were studied. Cytological evaluations of ear, skin and gingival swabs revealed an increased turnover of keratinocytes while the oxytetracycline ELISA determination showed an unexpected high amount of oxytetracycline in all cats at the first visit. All cats were then randomly assigned to receive a standard (SD group) or a nutraceutical diet (ND group) for 60 days. In the ND group a significant reduction of the mean serum concentration of oxytetracycline, pruritus intensity and skin lesion severity (**p<0.01, ***p<0.001, and ***p<0.001, respectively) was observed after 60 days, and associated with a significant improvement in the clinical picture. Although a direct correlation between oxytetracycline presence within cat sera and CAFR-related symptoms has never been described, this study highlights the benefit of a specific nutraceutical diet supplementation in improving clinical symptoms and skin lesions in cats with CARF.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2017
• Tom: 20
• Numer: 2
• Opis fizyczny: p.269-276,fig.,ref.

Twórcy

autor

Mazzeranghi F.

• Ambulatorio Veterinario Fiamma Mazzeranghi Traversa I di via Rudiano 9/e, 25032 Chiari, Brescia, Italy

autor

Zanotti C.

• Ambulatorio Veterinario Fiamma Mazzeranghi Traversa I di via Rudiano 9/e, 25032 Chiari, Brescia, Italy

autor

Di Cerbo A.

• Department of Medical, Oral and Biotechnological Sciences, Dental School, University “G. d’Annunzio” of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy

autor

Verstegen J.P.

• Department of Veterinary Medicine, University of Madison Wisconsin, Madison, WI 53706, USA

autor

Coccoa R.

• Department of Pathology and Veterinary Clinic, Faculty of Veterinary Medicine, University of Sassari, Sassari, Italy

autor

Guidetti G.

• SANYpet S.p.a., Research and Development Department, Via Austria 3, 35023 Bagnoli di Sopra, Padua, Italy

autor

Canello S.

• Forza10 USA Corp., Research and Development Department, Orlando, 6450 Kingspointe Pkwy Orlando Fl 32819, USA

Bibliografia

• Baker BB, Maibach HI (1987) Epidermal Cell Renewal In Seborrheic Skin Of Dogs. Am J Vet Res 48: 726-728.
• Baker BB, Maibach HI, Park RD (1974) Epidermal Cell Renewal In Dogs After Clipping Of The Hair. Am J Vet Res 35: 445-446.
• Baker BB, Maibach HI, Park RD, McFarland LZ, O’Brien TR (1973) Epidermal Cell Renewal In The Dog. Am J Vet Res 34: 93-94.
• Carlotti DN, Remy I, Prost C (1990) Food Allergy In Dogs And Cats. A Review And Report Of 43 Cases. Vet Dermatol 1: 55-62.
• Chi Z, Liu R, You H, Ma S, Cui H, Zhang Q (2014) Probing The In Vitro Cytotoxicity Of The Veterinary Drug Oxytetracycline. Plos One 9: E102334.
• Chopra I, Roberts M (2001) Tetracycline Antibiotics: Mode Of Action, Applications, Molecular Biology, And Epidemiology Of Bacterial Resistance. Microbiol Mol Biol Rev 65: 232-60; Second Page, Table Of Contents.
• Chuah LO, Effarizah ME, Goni AM, Rusul G (2016) Antibiotic Application And Emergence Of Multiple Antibiotic Resistance (MAR) In Global Catfish Aquaculture. Curr Environ Health Rep 3: 118-127.
• Cortese L, Annunziatella M, Palatucci AT, Lanzilli S, Rubino V, Di Cerbo A, Centenaro S, Guidetti G, Canello S, Terrazzano G (2015) An Immune-Modulating Diet Increases The Regulatory T Cells And Reduces T Helper 1 Inflammatory Response In Leishmaniosis Affected Dogs Treated With Standard Therapy. BMC Vet Res 11: 295.
• Destefanis S, Giretto D, Muscolo MC, Di Cerbo A, Guidetti G, Canello S, Giovazzino A, Centenaro S, Terrazzano G (2016) Clinical Evaluation Of A Nutraceutical Diet As An Adjuvant To Pharmacological Treatment In Dogs Affected By Keratoconjunctivitis Sicca. BMC Vet Res 12: 214.
• Di Cerbo A, Canello S, Guidetti G, Laurino C, Palmieri B (2014)a. Unusual Antibiotic Presence In Gym Trained Subjects With Food Intolerance; A Case Report. Nutr Hosp 30: 395-398.
• Di Cerbo A, Centenaro S, Beribe F, Laus F, Cerquetella M, Spaterna A, Guidetti G, Canello S, Terrazzano G (2016)a. Clinical Evaluation Of An Antiinflammatory And Antioxidant Diet Effect In 30 Dogs Affected By Chronic Otitis Externa: Preliminary Results. Vet Res Commun 40: 29-38.
• Di Cerbo A, Palatucci AT, Rubino V, Centenaro S, Giovazzino A, Fraccaroli E, Cortese L, Ruggiero G, Guidetti G, Canello S, Terrazzano G (2016)b. Toxicological Implications And Inflammatory Response In Human Lymphocytes Challenged With Oxytetracycline. J Biochem Mol Toxicol 30: 170-177.
• Di Cerbo A, Palmieri B, Chiavolelli F, Guidetti G, Canello S (2014)b. Functional Foods In Pets And Humans. Intern J Appl Res Vet Med 12: 192-199.
• Di Cerbo A, Pezzuto F, Canello S, Guidetti G, Palmieri B (2015). Therapeutic Effectiveness Of A Dietary Supplement For Management Of Halitosis In Dogs. J Vis Exp E52717.
• Di Cerbo A, Sechi S, Canello S, Guidetti G, Fiore F, Cocco R (2017). Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet. J Vis Exp 119: 54878.
• Graham F, Paradis L, Begin P, Paradis J, Babin Y, Des Roches A (2014). Risk Of Allergic Reaction And Sensitization To Antibiotics In Foods. Ann Allergy Asthma Immunol 113: 329-330.
• Guagumre E (1993). Food Intolerance In Cats With Cutaneous Manifestations. PMCAC 28: 451-460.
• Guidetti G, Di Cerbo A, Giovazzino A, Rubino V, Palatucci AT, Centenaro S, Fraccaroli E, Cortese L, Bonomo MG, Ruggiero G, Canello S, Terrazzano G (2016). In Vitro Effects Of Some Botanicals With Anti-Inflammatory And Antitoxic Activity. J Immunol Res 2016: 5457010.
• Food and Agriculture Organization Headquarters (2012). Maximum Residue Limits For Veterinary Drugs In Foods. Codex Alimentarius Commission. 35th Session. Ftp://Ftp.Fao.Org/Codex/Weblinks/MRL2–E–2012.Pdf.
• Gallo A, Landi R, Rubino V, Di Cerbo A, Giovazzino A, Palatucci AT, Centenaro S, Guidetti G, Canello S, Cortese L, Ruggiero G, Alessandrini A, Terrazzano G (2017). Oxytetracycline induces DNA damage and epigenetic changes: a possible risk for human and animal health? Peer J 5: e3236.
• Jackson DE, Selting KA, Spoor MS, Henry CJ, Wiedmeyer CE (2013). Evaluation Of Fixation Time Using Diff-Quik For Staining Of Canine Mast Cell Tumor Aspirates. Vet Clin Pathol 42: 99-102.
• Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG (2012). Improving Bioscience Research Reporting: The ARRIVE Guidelines For Reporting Animal Research. Osteoarthritis Cartilage 20: 256-260.
• Kimera ZI, Mdegela RH, Mhaiki CJ, Karimuribo ED, Mabiki F, Nonga HE, Mwesongo J (2015). Determination Of Oxytetracycline Residues In Cattle Meat Marketed In The Kilosa District, Tanzania. Onderstepoort J Vet Res 82: 911.
• Lee DH, Seo ES, Hong JT, Lee GT, You YK, Lee KK, Jo GW, Kim NK (2013). The Efficacy And Safety Of A Proposed Herbal Moisturising Cream For Dry Skin And Itch Relief: A Randomised, Double-Blind, Placebo-Controlled Trial-Study Protocol. BMC Complement Altern Med 13: 330.
• Maine IR, Atterbury R, Chang KC (2015). Investigation Into The Animal Species Contents Of Popular Wet Pet Foods. Acta Vet Scand 57: 7.
• Milch RA, Rall DP, Tobie JE (1957). Bone Localization Of The Tetracyclines. J Natl Cancer Inst 19: 87-93.
• Miller WH, Griffin CE, Campbell KL (2013). Muller And Kirk’s Small Animal Dermatology, Elsevier Health Sciences. pp 938.
• Mueller RS, Olivry T, Prelaud P (2016). Critically Appraised Topic On Adverse Food Reactions Of Companion Animals (2): Common Food Allergen Sources In Dogs And Cats. BMC Vet Res 12: 9.
• Odore R, De Marco M, Gasco L, Rotolo L, Meucci V, Palatucci AT, Rubino V, Ruggiero G, Canello S, Guidetti G, Centenaro S, Quarantelli A, Terrazzano G, Schiavone A (2015). Cytotoxic Effects Of Oxytetracycline Residues In The Bones Of Broiler Chickens Following Therapeutic Oral Administration Of A Water Formulation. Poult Sci 94: 1979-1985.
• Olivry T, Mueller RS, Prelaud P (2015). Critically Appraised Topic On Adverse Food Reactions Of Companion Animals (1): Duration Of Elimination Diets. BMC Vet Res, 11: 225.
• Oyelami OA, Onayemi A, Oyedeji OA, Adeyemi LA (2009). Preliminary Study Of Effectiveness Of Aloe Vera In Scabies Treatment. Phytother Res 23: 1482-1484.
• Palmieri B, Di Cerbo A, Laurino C (2014). Antibiotic Treatments In Zootechnology And Effects Induced On The Food Chain Of Domestic Species And, Comparatively, The Human Specie. Nutr Hosp 29: 1427-1433.
• Panahi Y, Davoudi SM, Sahebkar A, Beiraghdar F, Dadjo Y, Feizi I, Amirchoopani G, Zamani A (2012). Efficacy Of Aloe Vera/Olive Oil Cream Versus Betamethasone Cream For Chronic Skin Lesions Following Sulfur Mustard Exposure: A Randomized Double-Blind Clinical Trial. Cutan Ocul Toxicol 31: 95-103.
• Roudebush P, Guilford WG, Shanley KJ (2000). Adverse Reactions To Food. In: Hand MS, Thatcher CD, Remillard RL, Roudebush P. (Ed.) Small Animal Clinical Nutrition. Missouri: Mark Morris Institute. pp 1192.
• Scott DW (1988). Exfoliative Dermatoses In A Dog And A Cat Resembling Large Plaque Parapsoriasis In Humans. Companion Animal Practice 2: 22-29.
• Sidgwick GP, McGeorge D, Bayat A (2015). A Comprehensive Evidence-Based Review On The Role Of Topicals And Dressings In The Management Of Skin Scarring. Arch Dermatol Res 307: 461-477.
• Steffan J, Olivry T, Forster SL, Seewald W (2012). Responsiveness And Validity Of The SCORFAD, An Extent And Severity Scale For Feline Hypersensitivity Dermatitis. Vet Dermatol 23: 410-E77.
• The Commission of the European Communities (1996) Amending Annexes I And III To Council Regulation (EEC) No 2377/90 Laying Down A Community Procedure For The Establishment Of Maximum Residue Limits Of Veterinary Medicinal Products In Foodstuffs Of Animal Origin. Official Journal Of The European Communities.
• US Environmental Protection Agency AGENCY, U. E. P. (2014). Food And Drugs. PART 556 –Tolerances For Residues Of New Animal Drugs In Food. Subpart B-Specific Tolerances For Residues Of New Animal Drugs. Electronic Code Of Federal Regulations (Ecfr). Http://Www.Ecfr.Gov/.
• Verlinden A, Hesta M, Millet S, Janssens GP (2006). Food Allergy In Dogs And Cats: A Review. Crit Rev Food Sci Nutr 46: 259-273.
• White SD, Sequoia D (1989). Food Hypersensitivity In Cats: 14 Cases (1982-1987). J Am Vet Med Assoc 194: 692-695.

Identyfikatory

DOI

10.1515/pjvs-2017-0032