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2019 | 75 | 08 |
Tytuł artykułu

Relationship between mean platelet volume, low-grade systemic coagulation and vitamin D deficiency in canine visceral leishmaniasis

Autorzy
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Canine visceral leishmaniasis is associated with cardiac changes. This study was designed to test the hypothesis that vitamin D and coagulation parameters, such as D-dimer, activated partial thromboplastin time (APTT), partial thromboplastin time (PT), mean platelet volume (MPV), and white blood cell (WBC) levels, change in different stages of canine visceral leishmaniasis (CVL). Thirty-two dogs diagnosed with CVL were classified into four different groups: stage I (mild disease), stage II (moderate disease), stage III (severe disease), stage IV (very severe disease), and healthy controls. The groups were based on clinical signs, rapid ELISA/IFAT, hematological and serum biochemical tests, and urinary protein/creatinine ratios. Serum vitamin D levels were positively correlated with MPV (r = 0.503), but negatively correlated with D-dimer (r =-0.326), APTT (r =-0.361), PT (r =-0.289), and WBC (r = -0.384). The dogs with leishmaniasis showed increased WBC levels compared with the control group. Similarly, their vitamin D levels were significantly decreased compared with those in the control group (p<0.05). Severely diseased dogs (stage IV leishmaniasis) showed the lowest vitamin D levels, but there were no significant differences between dogs in the various stages of leishmaniasis. The evidence provided by this study indicates that the CVL dogs had low-grade systemic coagulation and fibrinolytic activation, as indicated by elevated MPV, PT, WBC and D-dimer levels, which may be used as a biomarker of low-grade systemic inflammation in CVL.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
75
Numer
08
Opis fizyczny
p.493-496,fig.,ref.
Twórcy
autor
  • Department of Internal Medicine, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydın, Turkey
autor
  • Department of Internal Medicine, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydın, Turkey
autor
  • Department of Internal Medicine, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydın, Turkey
Bibliografia
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
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