Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2019 | 75 | 08 |
Tytuł artykułu

Relationship between mean platelet volume, low-grade systemic coagulation and vitamin D deficiency in canine visceral leishmaniasis

Treść / Zawartość
Warianty tytułu
Języki publikacji
Canine visceral leishmaniasis is associated with cardiac changes. This study was designed to test the hypothesis that vitamin D and coagulation parameters, such as D-dimer, activated partial thromboplastin time (APTT), partial thromboplastin time (PT), mean platelet volume (MPV), and white blood cell (WBC) levels, change in different stages of canine visceral leishmaniasis (CVL). Thirty-two dogs diagnosed with CVL were classified into four different groups: stage I (mild disease), stage II (moderate disease), stage III (severe disease), stage IV (very severe disease), and healthy controls. The groups were based on clinical signs, rapid ELISA/IFAT, hematological and serum biochemical tests, and urinary protein/creatinine ratios. Serum vitamin D levels were positively correlated with MPV (r = 0.503), but negatively correlated with D-dimer (r =-0.326), APTT (r =-0.361), PT (r =-0.289), and WBC (r = -0.384). The dogs with leishmaniasis showed increased WBC levels compared with the control group. Similarly, their vitamin D levels were significantly decreased compared with those in the control group (p<0.05). Severely diseased dogs (stage IV leishmaniasis) showed the lowest vitamin D levels, but there were no significant differences between dogs in the various stages of leishmaniasis. The evidence provided by this study indicates that the CVL dogs had low-grade systemic coagulation and fibrinolytic activation, as indicated by elevated MPV, PT, WBC and D-dimer levels, which may be used as a biomarker of low-grade systemic inflammation in CVL.
Słowa kluczowe
Opis fizyczny
  • Department of Internal Medicine, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydın, Turkey
  • Department of Internal Medicine, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydın, Turkey
  • Department of Internal Medicine, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydın, Turkey
  • Al-Bajalan M. M., Niranji S. S., Al-Ja S. M., Kato H.: First identification of L. major in a dog in an endemic area of human cutaneous leishmaniasis in Iraq: molecular and phylogenetic studies. J. Parasitol. Res. 2018, 117, 585-590.
  • Bozkurt N., Yilmaz E., Biri A., Taner Z., Himmetoğlu O.: The mean platelet volume in gestational diabetes. J. Thromb. Thrombolysis 2006, 22, 51-54.
  • Cantorna M. T., Humpal-Winter J., DeLuca H. F.: In vivo upregulation of interleukin-4 is one mechanism underlying the immunoregulatory effects of 1, 25-dihydroxyvitamin D3. Arch. Biochem. Biophys. 2000, 377, 135-138.
  • Cantorna M. T., Zhu Y., Froicu M., Wittke A.: Vitamin D status, 1, 25-dihydroxyvitamin D3, and the immune system. Am. J. Clin. Nutr. 2004, 80, 1717-1720.
  • Ciaramella P., Pelagalli A., Cortese L., Pero M. E., Corona M., Lombardi P., Persechino A.: Altered platelet aggregation and coagulation disorders related to clinical findings in 30 dogs naturally infected by Leishmania infantum. Vet. J. 2005, 169, 465-467.
  • Costagliola A., Piegar G., Otrocka-Domagala I., Ciccarelli D., Iovane V., Oliva G., Paciello O.: Immunopathological features of canine myocarditis associated with Leishmania infantum infection. Biomed. Res. Int. 2016, 6.
  • D’ambrosio D., Cippitelli M., Cocciolo M. G., Mazzeo D., Di Lucia P., Lang R., Panina-Bordignon P.: Inhibition of IL-12 production by 1, 25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J. Clin. Invest. 1998, 10, 252-262.
  • Dandrieux J. R. S., Sacchini F., Harms G., Globokar M., Balzer H. J., Pantchev N.: Canine Leishmania infantum infection: an imported case in UK after staying in the Canary Islands. J. Parasitol. Res. 2018, 117, 331-334.
  • Dos Santos F. P., Pascon J., Pereira D., Anjos B. L., Mistieri M., Silveira I. D., Porciuncula M. L.: Clinical and histopathological features of myocarditis in dogs with visceral leishmaniasis. Arq. Bras. Med. Vet. Zootec. 2015, 67, 1519-1527.
  • Ehrchen J., Helming L., Varga G., Pasche B., Loser K., Gunzer M., Lengeling A.: Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania major. FASEB J. 2007, 21, 3208-3218.
  • Erikçi A. A., Muhçu M., Dündar O., Oztürk A.: Could mean platelet volume be a predictive marker for gestational diabetes mellitus? Hematol. 2008, 13, 46-48.
  • Font A., Closa J. M., Molina A., Mascort J.: Thrombosis and nephritic syndrome in a dog with visceral leishmaniasis. J. Small. Anim. Pract. 1993, 34, 466-470.
  • Gillum R. F., Mussolino M. E., Madans J. H.: Counts of neutrophils, lymphocytes, and monocytes cause specific mortality and coronary heart disease: the NHANES-I epidemiologic follow-up study. Ann. Epidemiol. 2005, 15, 266-271.
  • Jakubowski J. A., Thompson C. B., Vaillancourt R., Valeri C. R., Deykin D.: Arachidonic acid metabolism by platelets of differing size. Br. J. Haematol. 1983, 53, 503-511.
  • Kaabi B., Zhioua E.: Modeling and comparative study of the spread of zoonotic visceral leishmaniasis from Northern to Central Tunisia. Acta Trop. 2018,178, 19-26.
  • Kebapcilar A. G., Kulaksizoglu M., Ipekci S. H., Korkmaz H., Kebapcilar L., Akyurek F., Gone M. S.: Relationship between mean platelet volume and low-grade systemic coagulation with vitamin D deficiency in primary ovarian insufficiency. Arch. Gynecol. Obstet. 2013, 288, 207-212.
  • Koyama T., Hirosawa S.: Anticoagulant effects of synthetic retinoids and activated vitamin D3. Semin. Thromb. Hemost. 1998, 24, 217-226.
  • Kunadian V., Ford G. A., Bawamia B., Qiu W., Manson J. E.: Vitamin D deficiency and coronary artery disease: a review of the evidence. Am. Heart. J. 2014, 167, 283-291.
  • Le Rutte E. A., van Straten R., Overgaauw P. A.: Awareness and control of canine leishmaniosis: A survey among Spanish and French veterinarians. Vet. Parasitol. 2018, 253, 87-93.
  • Lemire J. M.: Immunomodulatory actions of 1, 25-dihydroxyvitamin D3. J. Steroid. Biochem. Mol. Biol. 1995, 53, 599-602.
  • Lomtadze M. L., Khochava M. A., Shalamberidze. I. A., Shilakadze M. A., Dzhokhtaberidze T. G.: Functional status of haemostasis system in patients with visceral leishmaniasis. Georgian Med. News. 2005, 128, 59-62.
  • López-Peña M., Alemañ N., Muñoz F., Fondevila D., Suárez M. L., Goicoa A., Nieto J. M.: Visceral leishmaniasis with cardiac involvement in a dog: a case report. Acta Vet. Scand. 2009, 51, 20.
  • Mattner F., Smiroldo S., Galbiati F., Muller M., Di Lucia P., Poliani P. L., Adorini L.: Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1, 25-dihydroxyvitamin D3. Eur. J. Immunol. 2000, 30, 498-508.
  • Özata F., Ural K.: Thrombocyte indices in dogs infected with Ehrlichia canis and Anaplasma phagocytophilum. Rev. MVZ Cordoba 2014, 19, 4277-4288.
  • Ramos-Martínez E., Gutierrez-Kobeh L., Villaseñor-Cardoso M. I.: The role of vitamin D in the control of Leishmania infection. Can. J. Physiol. Pharmacol. 2015, 93, 369-376.
  • Rosa F. A., Leite J., Braga E. T., Moreira P., Baltazar F. H., Biondo A. W., Machado G. F.: Cardiac lesions in 30 dogs naturally infected with Leishmania infantum chagasi. Vet. Pathol. 2014, 51, 603-606.
  • Sato E., Imafuku S., Ishii K., Itoh R., Chou B., Soejima T., Hiromatsu K.: Vitamin D-dependent cathelicidin inhibits Mycobacterium marinum infection in human monocytic cells. J. Dermatol. Sci. 2013, 70, 166-172.
  • Shor R., Tirosh A., Shemesh L., Krakover R., Bar Chaim A., Mor A.: 25 hydroxyvitamin D levels in patients undergoing coronary artery catheterization. Eur. J. Intern. Med. 2012, 23, 470-473.
  • Solano-Gallego L., Miró G., Koutinas A., Cardoso L., Pennisi M. G., Ferrer L., Baneth G.: LeishVet guidelines for the practical management of canine leishmaniosis. Parasit. Vectors. 2011, 4, 86.
  • Syal S. K., Kapoor A., Bhatia E., Sinha A., Kumar S., Tewari S.: Vitamin D deficiency, coronary artery disease, and endothelial dysfunction: observationsfrom a coronary angiographic study in Indian patients. J. Inv. Cardiol. 2012, 24, 385-389.
  • Terrazzano G., Cortese L., Piantedosi D., Zappacosta S., Di Loria A., Santoro D., Ciaramella P.: Presence of anti-platelet IgM and IgG antibodies in dogs naturally infected by Leishmania infantum. Vet. Immunol. Immunopathol. 2006, 110, 331-337.
  • Torrent E., Leiva M., Segalés J., Franch J., Peña T., Cabrera B., Pastor J.: Myocarditis and generalised vasculitis associated with leishmaniosis in a dog. J. Small. Anim. Pract. 2005, 46, 549-552.
Typ dokumentu
Identyfikator YADDA
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.