Cortical feedback modulates temporal pattern of spontaneous neuronal activity in the cat's dorsal lateral geniculate and perigeniculate nuclei

• Autorzy: Radzikowska Z. , Waleszczyk W. , Bekisz M. , Wrobel A.
• Języki publikacji: EN

Abstrakty

EN

In cats with pretrigeminal brainstem transections, reversible inactivation of the primary visual cortex by cooling results in changes of the magnitude of response and spatio-temporal structure of receptive fi elds of neurons from lateral geniculate and perigeniculate nuclei (LGNd and PGN; Waleszczyk et al. 2005). Since cortical inactivation changes also the spontaneous activity of these thalamic neurons, we hypothesized that cortical feedback affects their membrane potential. Both types of investigated cells displayed two modes of activity: a tonic mode, during depolarization; and a burst mode, when the cell is hyperpolarized. In this report we investigated the effect of elimination of cortical feedback by cooling on the temporal pattern of the spontaneous "bursty" activity of single neurons in LGNd and PGN. During such reversible inactivation of areas 17 and 18, in both LGNd and PGN cells, spontaneously occurring bursts exhibited longer interspike intervals (ISIs) and lower number of spikes, while the average burst duration remained unchanged. Longer ISIs suggest that cortical feedback infl uences not only visual responsiveness of thalamic neurons, but also temporal pattern of their spontaneous fi ring, in line with the hypothesis of a tonic cortical modulation of their membrane potential. Supported by the Ministry of Science and Higher Education grant COST/127/2007.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.324

Twórcy

autor

Radzikowska Z.

• Department of Neurophysiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Waleszczyk W.

• Department of Neurophysiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Bekisz M.

• Department of Neurophysiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Wrobel A.

• Department of Neurophysiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland