Vaccine preservative, thimerosal, affects pain sensivity, body temperature and prefrontal cortex in rats

• Autorzy: Duszczyk M. , Olczak M. , Mierzejewski P. , Majewska M.
• Języki publikacji: EN

Abstrakty

EN

Mercury compounds are known neurotoxins. Thimerosal (THIM), which contains molecularly 49% of mercury, is added as preservative to many child vaccines and is suspected to be a major factor in autism pathogenesis. Data from Adverse Event Reporting of the Center for Disease Control and Prevention (USA) provide epidemiological evidence for a link between mercury exposure from THIM-containing vaccines and autism or other neurodevelopmental disorders. Our earlier studies showed that neonatally administered THIM causes persistent changes in pain reactivity, which are manifested in adult rats. In this study we investigated acute effects of THIM on pain reactivity, body temperature and brain glutamatergic system in mature rats. Single injection of THIM induced marked hypoalgesia, measured in hot plate test. This effect was time- and dose-dependent. It was reversed by administration of naloxone before the test and by two neurosteroids – dehydroepiandrosterone sulfate and androsterone. THIM also caused a dose-dependent hypothermia. Administration of THIM directly to the prefrontal cortex of freely moving rats increased the extracellular concentration of glutamate. The results suggest that acute THIM injection rapidly changes the neurochemical systems related to glutamate, opioid peptides, and probably GABA, which may contribute to developmental and neurotoxic effect of this compound. Funded by EC grant MEXC-CT-2006-42371 to M. D. Majewska.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.309

Twórcy

autor

Duszczyk M.

• Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Olczak M.

• Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Mierzejewski P.

• Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Majewska M.

• Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland