Biological evaluation of quaternary bis ammonium salt and cetylpyridinum bromide against S. epidermidis biofilm

• Autorzy: Stefanska J. , Pietruczuk-Padzik A. , Struga M. , Borkowski M. , Tyski S.
• Języki publikacji: EN

Abstrakty

EN

Quaternary ammonium compounds are broad-spectrum bacteriocides widely used as antiseptics, disinfection and preservation agents. The aim of this study was to examine the activity of two quaternary ammonium salts, cetylpyridinum bromide and a newly synthesized quaternary bis ammonium salt, against S. epidermidis biofilm. The average values of killing efficiency for cetylpyridinum bromide ranged from 26.6% to 64.1% for all tested concentrations (0.125 to 8.0 μg×mL⁻¹) and for quaternary bis ammonium salt the percentage of killing efficiency ranged from 59.7% to 88.4% for tested concentrations (from 2.0 to 128.0 μg×mL⁻¹). Both tested compounds significantly affect staphylococcal biofilms, but any of used concentrations caused a total eradication of bacterial biofilm.

Słowa kluczowe

EN

quaternary ammonium salt; cetylpyridinum bromide; disinfectant; preservation agent; Staphylococcus epidermidis; bacterial biofilm

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2013
• Tom: 62
• Numer: 4
• Opis fizyczny: p.359-364,fig.,ref.

Twórcy

autor

Stefanska J.

• Department of Pharmaceutical Microbiology, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland

autor

Pietruczuk-Padzik A.

• Department of Pharmaceutical Microbiology, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland

autor

Struga M.

• Department of Medicinal Chemistry, Medical University of Warsaw, Warsaw, Poland

autor

Borkowski M.

• Department of Antibiotics and Microbiology, National Medicine Institute, Warsaw, Poland

autor

Tyski S.

• Department of Pharmaceutical Microbiology, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland

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