Neurogenesis in gerbil hippocampus following brain ischemia-involvement of MMPs

• Autorzy: Wojcik L. , Zalewska T.
• Języki publikacji: EN

Abstrakty

EN

Accumulating evidence indicate that global cerebral ischemia enhanced neurogenesis in adult brain. The mechanism(s) responsible for the arising a new neurons from progenitor cells are poorly understood. Recent in vitro studies indicate the involvement of metalloproteinases (MMPs) in the regulation of proliferation and differentiation of neural progenitor cells, by providing an environment, which is instructive and/or permissive to stem cells activation. To elucidate if MMPs participate in neurogenesis-associated processes after ischemic insult in vivo, we aimed to establish spatial and temporal relationships between neural stem cells development and the modulations of MMPs enzymatic activity in the adult hippocampal dentate gyrus as well as in the ischemia damaged CA1 sector. Our results show that postischemic acceleration of progenitor proliferation in dentate gyrus is accompanied by the increase of MMPs activity. It may indicate that activation of MMPs is likely to be involved in neurogenesis-associated processes. Contrary, the endogenous neurogenesis in the ischemia damaged CA1 pyramidal layer seems to be rather elusive. Despite the appearance of BrdUpositive cells and the newborn neurons they did not attain maturity. Simultaneously, the activity of MMPs in this area was markedly reduced. The increase of MMPs activity seen in the astrocytes in the neighboring structures ñ stratum oriens and stratum radiatum, probably plays a role in delayed tissue remodeling and delayed repair processes. In conclusion, our results show that MMPs may, at least in part, contribute to ischemia-induced neurogenesis in the dentate gyrus of the adult brain, along with other previously reported factors. This work was supported by MSHE grant 1266/P01/2006/31

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 1
• Opis fizyczny: p.104-105

Twórcy

autor

Wojcik L.

• NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Zalewska T.

• NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland