Alteration of brain stem auditory evoked potentials after intracerebroventricular administration of met-enkephalin in rabbits

• Autorzy: Gregorowicz K. , Kosinski S. , Traczyk W.Z.
• Języki publikacji: EN

Abstrakty

EN

Gregorowicz К., Kosiński S., Traczyk W. Z.: Alteration of brain stem auditory evoked potentials after intracerebroventricular administration of met-enkephalin in rabbits. Acta Physiol. Pol. 1990, 41(1-3): 63-70. Brainstem auditory evoked potentials (BAEPs) were elicited by binaural click stimulation and recorded from the rabbits with chronically implanted electrodes and a cannula for intracerebroventricular injection (i.c.v.). 4000 BAEPs were averaged off line. The registration was carried out before and after i.c.v. injection of met-enkephalin (2.5 or 25 nmol), naloxon (20 μg ), or i.v. injection of morphine (1.0, 2.0, 5.0 mg/kg b.w.). Enkephalin caused shortening of interpeak latency time, naloxon caused its lengthening, while the effect of morphine was not unidirectional. Enkephalin caused increase in the surface area below the negative peaks located in the range of 4.5-7.5 ms from the first positive peak, naloxon caused its decrease while the effect of morphine was also in this respect not unidirectional. It is concluded that opiate receptors are involved in the modulation of the auditory brainstem responses.

Słowa kluczowe

EN

alteration; brain stem; auditory evoked potential; intracerebroventricular administration; met-enkephalin; rabbit; cerebral ventricle

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1990
• Tom: 41
• Numer: 1-3
• Opis fizyczny: p.63-70,fig.,ref.

Twórcy

autor

Gregorowicz K.

• Department of Physiology, Institute of Physiology and Biochemistry, Medical University, Lodz, Poland

autor

Kosinski S.

• Department of Physiology, Institute of Physiology and Biochemistry, Medical University, Lodz, Poland

autor

Traczyk W.Z.

• Department of Physiology, Institute of Physiology and Biochemistry, Medical University, Lodz, Poland

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