Association of HLA-G polymorphism and susceptibility to toxoplasmosis infection in rheumatoid arthritis patients

• Autorzy: Saba A.M. , Jasim H.M. , Al-Qadhi B.N.
• Języki publikacji: EN

Abstrakty

EN

Toxoplasma gondii (T. gondii) is an intracellular protozoan parasite that can infect approximately one-third of the world’s human population. HLA-G level change is one immune evasion tactic in the host-parasite interaction. The immune system can be suppressed by HLA-G, a special protein (non-classical HLA class I) molecule that has the ability to control natural killer cell (NK) activity such as cytotoxicity and cytokine production through NK cell receptors. HLA-G level modification is one immune evasion mechanism in the host-parasite interaction. The immune system can be suppressed by HLA-G, a special protein (non-classical HLA class I) molecule that has the ability to control natural killer cell (NK) activity such as cytotoxicity and cytokine generation through NK cell receptors. This study aimed to investigate the alteration in sHLA-G levels could be impressed by present of Toxoplasma and rheumatoid as well as the seroprevalence of Toxoplasma gondii (T. gondii) antibodies in Iraqi patients with rheumatoid arthritis was investigated. The prevalence of anti-T. gondii IgG was 50% in arthritic patients in comparison to 41.6% in healthy controls. No positive anti-T. gondii IgM was detected. In the current study evaluate the possible association of the HLA-G gene polymorphisms with susceptibility to RA and toxoplasmosis by study two polymorphism at exon 8 (rs17179101 and 14 bp ins/del). Ultimately there were significant association between two diseases that have been studied and 14 bp ins/del and snp (rs17179101).

• Wydawca: -
• Czasopismo: Annals of Parasitology
• Rocznik: 2022
• Tom: 68
• Numer: 4
• Opis fizyczny: p.821-828,fig.,ref.

Twórcy

autor

Saba A.M.

• Department of Biology, College of Science, University of Baghdad, Al-Jaderiya Campus, Blook A, Risafa District, Baghdad 10071, Iraq

autor

Jasim H.M.

• College of Biotechnology, University of Nahrain, Al-Jaderiya Campus, Risafa District, Baghdad 10071, Iraq

autor

Al-Qadhi B.N.

• Department of Biology, College of Science, University of Baghdad, Al-Jaderiya Campus, Blook A, Risafa District, Baghdad 10071, Iraq

Identyfikatory

DOI

10.17420/ap6804.490