Clinico-pathological studies of Plasmodium falciparum and Plasmodium vivax – malaria in India and Saudi Arabia

• Autorzy: Khan W. , Zakai H. A. , Asma U.
• Języki publikacji: EN

Abstrakty

EN

Malaria is one of the most devastating diseases of tropical countries with clinical manifestations such as anaemia, splenomegaly, thrombocytopenia, hepatomegaly and acute renal failures. In this study, cases of thrombocytopenia and haemoglobinemia were more prominent in subjects infected with Plasmodium falciparum (Welch, 1897) than those with Plasmodium vivax (Grassi et Feletti, 1890). However, anaemia, jaundice, convulsions and acute renal failure were significantly high (3–4 times) in subjects infected with P. falciparum than those infected with P. vivax. The incidence of splenomegaly and neurological sequelae were 2 and 6 times higher in P. falciparum infections compared to the infections of P. vivax. Both in P. vivax and P. falciparum malaria, the cases of splenomegaly, jaundice and neurological sequelae were almost double in children (<10 years) compared to older patients. The liver enzymes were generally in normal range in cases of low and mild infections. However, the AST, ALT, ALP activities and serum bilirubin, creatinine, and the urea content were increased in P. falciparum and P. vivax malaria patients having high parasitaemia, confirming liver dysfunction and renal failures in few cases of severe malaria both in India and Saudi Arabia.

Słowa kluczowe

EN

malaria; tropical disease; infectious disease; Plasmodium vivax; Plasmodium falciparum; pathology; liver enzyme; splenomegaly; thrombocytopenia; liver dysfunction; renal failure; India; Saudi Arabia

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 2014
• Tom: 59
• Numer: 2
• Opis fizyczny: p.206-212,fig.,ref.

Twórcy

autor

Khan W.

• Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia

autor

Zakai H. A.

• Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia

autor

Asma U.

• Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, UP, India

Bibliografia

• Ahsan T., Ali H., Bkaht S.F., Ahmad N., Farooq M.U., Shaheer A., Mahmood T. 2008. Jaundice and P. falciparum malaria: Changing trends in clinical presentation-A need for awareness. Journal Pakistan Medical Association, 58, 616–621.
• Anikar A.R., Singh D.K., Singh R., Das A.P., Valeecha N. 2010. Vivax malaria presenting with cerebral malaria and convulsions. Acta Parasitologica, 55, 96–98.
• Banzal S., Ayoola F.A., El Sammani F.E., Rahim S.I., Subramanium P., Gadour M.O.E., Jain A.K. 1999. The clinical pattern and complications of severe malaria in the Jazan region of Saudi Arabia. Annals Saudi Medicine, 19, 378–380.
• Bashawri L.A., Mandil A.A., Bahnassy A.A., Ahmed M.A., Al-Shamsi M.A., Bukhari H.A. 2001. Epidemiological profile of malaria in a university hospital in eastern region of Saudi Arabia. Saudi Med. J. 22,133–138.
• Brewster D.R., Kwiatkowski D., White N. J. 1990. Neurological sequelae of cerebral malaria in children. Lancet, 27,336(8722), 1039–1043.
• Burtis C.A., Ashood E.R. (Eds.). 1999. Text Book of clinical chemistry, Philadelphia, Saunders Company, pp. 616–721.
• Chawla L.S., Sidhu G., Sabharwal B.D., Bhatia K.L., Sood A. 1989. Jaundice in P. falciparum. Journal of the Association of Physicians of India, 37, 390–392.
• Douglas N.M., Anstey N.M., Buffet P.A., Poespoprodjo J.R., Yeo T., White N.J., Price R.N. 2012. The anaemia of Plasmodium vivax malaria. Malaria Journal, 11, 135. DOI: 10.1186/1475-2875-11-135.
• Echeverri M., Tobon A., Alvarez G., Carmona J., Blair S. 2003. Clinical and laboratory findings of Plasmodium vivax malaria in Columbia 2001. Revista do Instituto de Medicina Tropical de São Paulo, 45, 29–34.
• Engwerda C.R., Beattie L., Amante F.H. 2005. The importance of the spleen in malaria. Trends in Parasitology, 21, 75–80.
• Harris V.K., Richard V.S., Mathi E., Sitaram U., Kumar K.V., Cherian A.M., Amelia S.M., Anand G. 2001. A study on clinical profile of P. falciparum malaria in a tertiary care hospital in south India. Indian Journal of Malariology, 38, 19–24.
• Idro R., Ndiritu M., Ogutu B., Mithwani S., Maitland K., Berkley J., Crawley J., Fegan G., Bauni E., Peshu N., Marsh K., Neville B., Newton C. 2007. Burden, features, and outcome of neurological involvement in acute P. falciparum malaria in Kenyan children. Journal of the American Medical Association, 297, 2232–2240.
• Jadhav U.M., Patkar V.S., Kadam N.N. 2004. Thrombocytopaenia in malaria-correlated with type and severity of malaria. Journal of the Association of Physicians of India, 52, 615–618.
• Joseph V., Verma M., Vidhyasagar S., Mathew A. 2011. Comparision of clinical profile and complications of mixed malarial infections of P. falciparum and P. vivax versus P. falciparum Monoinfection. Sultan Qaboos University Medical Journal, 11, 377–382.
• Kalpana A. (Ed.). 1965. Standard Methods of Clinical Chemistry. New York Academic Press. pp. 245–256.
• Kochar D.K., Das A., Kochar A., Midha S., Acharya J., Tanwar G.S., Gupta A., Pakalapati D., Garg S., Saxena V., Subudhi A.K., Boopathi P.A., Sirohi P., Kochar S.K. 2010. Thrombocytopenia in P. falciparum, P. vivax and mixed infection malaria: A study from Bikaner (North western India). Platelets, 21, 623–627.
• Kochar D.K., Kaswan K., Kochar S.K., Sirohi P., Pal M., Kochar A. 2006. A comparative study of regression of jaundice in patients of malaria and acute viral hepatitis. Journal of Vector Borne Diseases, 43, 123–129.PubMedGoogle Scholar
• Lança E.F.C., MagalhĂes B.M.L., Vitor-Silva S., Siqueira A.M., Benzecry S.G., Alexandre M.A.A., O’Brien C., Bassat Q., Lacerda M.V.G. 2012. Risk factors and characterization of Plasmodium vivax-associated admissions to Pediatric Intensive Care Units in the Brazilian Amazon. PLoS ONE, 7(4), e35406.
• Limaye S.L., Londhey V.A., Nabar S.T. 2012. The study of complications of vivax malaria in comparision with P. falciparum malaria in Mumbai. Journal of the Association of Physicians of India, 60, 15–18.
• Maheshwari A., Singh A.K., Sinha D.K., Tripathy K., Prakash J. 2004. Spectrum of renal disease in malaria. Journal of the Indian Medical Association,102, 143–146.
• Malik G.M., Seidi O., El-Taher A.M., Mohammad A.S. 1998. Clinical aspect of malaria in the Asir region Saudi Arabia. Annals of Saudi Medicine, 18, 15–17.
• Marsh K., Forster D., Waruiru C., Mwangi I., Winstanley M., Marsh V., Newton C., Winstanley P., Warn P., Peshu N. 1995. Indicators of life-threatening malaria in African children. New England Medical Journal, 332, 1399–1404.
• Mazumder R., Mishra R.K., Mazumdar H., Mukherjee P. 2002. Jaundice and P. falciparum malaria: Some prospective observations. Journal of the Indian Medical Association, 100, 312–314.
• Mehta K.S., Halankar A.R., Makwana P.D., Torane P.P., Satija P.S., Shah V.B. 2001. Severe acute renal failure in malaria. Journal of Postgraduate Medicine, 47, 24–26.
• Naqvi R., Ahmad E., Akhtar F., Naqvi A., Rizvi A. 2003. Outcome in severe acute renal failure associated with malaria. Nephrology Dialysis Transplantation, 18, 1820–1823.
• Ngoungou E.B., Poudiougou B., Dulac O., Dicko A., Boncoeur M.P., Traoré A.M., Coulibaly D., Keita M.M., Preux P.M., Doumbo O.K., Druet-Cabanac M. 2007. Persistent neurological sequelae due to cerebral malaria in a cohort of children from Mali. Review Neurology, (Paris),163, 583–588.
• Onyesom, Onyemakonor N. 2011. Level of parasitaemia and changes in some liver enzymes among malarial infected patients in Edo-Delta region of Nigeria. Current Research Journal of Biological Sciences, 3, 78–81.
• Parakash J., Singh A.K., Kumar N.S., Saksena R.K. 2003. Acute renal failure in Plasmodium vivax malaria. Journal of the Association of Physicians of India, 51, 265–267.
• Picot S., Bienvenu A.L. 2009. [Plasmodium vivax infection: not so benign]. Medical Science, (Paris), 25, 622–626. DOI: 10.1051/medsci/2009256-7622.
• Quintero J. P., Siqueira A.M., Tobón A., Blair S., Moreno A., Arévalo-Herrera M., Lacerda M.V., Valencia S.H. 2011. Malariarelated anaemia: a Latin American perspective. Memórias do Instituto Oswaldo Cruz, 106 Suppl.,1, 91–104.
• Rodrigues-Morales A.J., Sanchez E., Vergas M., Piccolo C., Colina R., Arria M. 2006. Anaemia and thrombocytopaenia in children with Plasmodium vivax malaria. Journal of Tropical Pediatrics, 52, 49–51.
• Sharma A., Khanduri U. 2009. How benign is benign tertian malaria?. Journal of Vector Borne Diseases, 46, 141–144
• Singh H., Parakh A., Basu S., Rath B. 2011. Plasmodium vivax malaria: is it actually benign? Journal of Infection and Public Health, 4, 91–95.
• Sonkar S.K., Uniyal R., Sonkar G.K. 2011. Three unusual presentations of Plasmodium vivax malaria. Tropical Doctor, 41, 240–241.
• Srivastava S., Ahmad S., Shirazi N., Kumar Verma S., Puri P. 2011. Retrospective analysis of vivax malaria patients presenting to tertiary referral centre Uttarakhand. Acta Tropica, 117, 82–85.
• Tangpukdee N., Thanachartwet V., Krudsood S., Luplertlop N., Pornpininworakij K., Chalermrut K., Phokham S., Kano S., Looareesuwan S., Wilairatana P. 2006. Minor liver profile dysfunctions in Plasmodium vivax, P. malariae and P. ovale patients and normalization after treatment. Korean Journal of Parasitology, 4, 295–302.
• Thanachachartwet V., Desacorn V., Sahassananda D., Win K.Y.K.K., Supaporn T. 2013. Acute renal failure in patients with severe falciparum malaria: Using the WHO 2006 and RIFLE Criteria. International Journal of Nephrology. Article ID841518, 6 pages. http://dx.doi.org/ 10.1155/2013/841518.
• Thomas L. (Ed.). 1998. Clinical Laboratory diagnostics. Frankfurt, TH-Books Verlagsgesellschaft, 366–374.
• Tjitra E., Anstey N.M., Sugiarto P., Warikar N., Kenangalem E., Karyana M. Lampah D.A., Price N.R. 2008. Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: A prospective study in Papua, Indonesia. PLoS Medicine, 5, e128. DOI: 10.1371/journal.pmed.0050128.
• Tripathy R., Parida S., Das L., Mishra D.P., Tripathy D., Das M.C., Chen H., Maguire J.H., Panigrahi P. 2007. Clinical manifestations and predictors of severe malaria in Indian children. Pediatrics, 120, e454–460.
• Uzuegbu U.E., Emeka C.B. 2011. Changes in liver function markers among malaria infected patients in Ikeja Lagos State, Nigeria. Current Research Journal of Biological Sciences, 3, 172–174.
• Vannaphan S., Walters N., Saengnedsawang T., Tangpukdee N., Kham-In P., Molleudee K., Wilairatana P., Looareesuwan S., 2010. Factors Associated with acute renal failure in severe P. falciparum malaria patients. Southeast Asian Journal of Tropical Medicine and Public Health, 41, 1042–1047.PubMedGoogle Scholar
• Wickramasinghe S.M., Abdallah S.H. 2000: Blood and bone marrow changes in Malaria. Baillieres Best Practice & Research Clinical Haematology, 13, 277–299.
• Wilkinson J.H., Baron D.N., Moss D.W., Walker P.G. 1972. Standardization of clinical enzyme assays: A reference method for aspartate and alanine transaminases. Journal of Clinical Pathology, 25, 940.
• World Health Organization (WHO). World Malaria Report 2011. www.who.int/malaria/publications/atoz.