Tiapride impairs the aversive effect of electrical stimulation of the parabrachial complex in a conditioned place task

• Autorzy: Hurtado M.M. , Garcia R. , Puetro A.
• Języki publikacji: EN

Abstrakty

EN

The parabrachial complex has been related to various rewarding or aversive behavioral processes, including taste aversion learning and conditioned place aversion. This study examined the effect of tiapride, an antagonist of D2/D3 dopaminergic receptors, on place aversion induced by electrical stimulation of the external lateral parabrachial (LPBe) nucleus. Results obtained show that brain-stimulated animals avoid the area of the maze associated with electrical stimulation but show no such behavioral rejection when they receive an injection of 30 mg/kg tiapride. Furthermore, tiapride did not appear to affect the horizontal motor activity (crossing) of the animals. These results are discussed in the context of the different natural and artificial modalities used to induce aversive behavior and their relationship with dopamine systems.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.307-316,fig.,ref.

Twórcy

autor

Hurtado M.M.

• Department of Psychobiology, University of Granada, Campus of Cartuja, Granada, Spain

autor

Garcia R.

• Department of Psychobiology, University of Granada, Campus of Cartuja, Granada, Spain

autor

Puetro A.

• Department of Psychobiology, University of Granada, Campus of Cartuja, Granada, Spain

Bibliografia

• Agüero A, Arnedo M, Gallo M, Puerto A (1993a) Lesions of the lateral parabrachial nuclei disrupt aversion learning induced by electrical stimulation of the area postrema. Brain Res Bull 30: 585-592.
• Agüero A, Arnedo M, Gallo M, Puerto A (1993b) The func¬tional relevance of the lateral parabrachial nucleus in lithium chloride-induced aversion learning. Pharmacol Biochem Behav 45: 973-978.
• Andrade-Franzé GM, Andrade CA, De Luca LA, De Paula PM, Menani JV (2010) Lateral parabrachial nucleus and central amygdala in the control of sodium intake. Neuroscience 165: 633-641.
• Arnedo M, Gallo M, Agüero A, Puerto A (1990a) Effects of medullary afferent vagal axotomy and area postrema lesions on short-term and long-term NaCl-induced taste aversion learning. Physiol Behav 47: 1067-1074.
• Arnedo M, Gallo M, Agüero A, Molina F, Puerto A (1990b) Medullary afferent vagal axotomy disrupts NaCl-induced short-term taste aversion learning. Behav Neural Biol 59: 69-75.
• Arnedo M, Gallo M, Agüero A, Molina F, Puerto A (1993) Medullary afferent vagal axotomy disrupts NaCl-induced short-term taste aversion learning. Behav Neural Biol 59: 69-75.
• Balaban CD, Thayer JF (2001) Neurological bases for bal¬ance-anxiety links. J Anxiety Disord 15: 53-79.
• Balcells-Olivero M, Vezina P (1997) Effects of naltrexone on amphetamine-induced locomotion and rearing: acute and repeated injections. Psychopharmacology 131: 230¬238.
• Bechara A, Van der Kooy D (1992) Lesions of the tegmental pedunculopontine nucleus: Effects on locomotor activity induced by morphine and amphetamine. Pharmacol Biochem Behav 42: 9-18.
• Bechara A, Martin GM, Pridgar A, van der Kooy D (1993) The parabrachial nucleus: a brain stem substrate critical for mediating the aversive motivational effects of mor¬phine. Behav Neurosci 107: 147-160.
• Bender S, Scherbaum N, Soyka M, Rüther E, Mann K, Gastpar M (2007) The efficacy of the dopamine D2/D3 antagonist tiapride in maintaining abstinence: a random¬ized, double-blind, placebo-controlled trial in 299 alco¬hol-dependent patients. Int J Neuropsychopharmacol 10: 653-660.
• Bernard JF, Huang GF, Besson JH (1994) The parabrachial area: Electrophysiological evidence for an involvement in visceral nociceptive processes. J Neurophysiol 71: 1646-1660.
• Brown EE, Fibiger HC (1992) Cocaine-induce conditioned locomotion: absence of associated increases in dopamine release. Neuroscience 48: 621-629.
• Cannon CM, Bseikri MR (2004) Is dopamine required for natural reward? Physiol Behav 81: 741-748.
• Cannon CM, Palmiter RD (2003) Reward without dop¬amine. J Neurosci 23: 10827-10831.
• Carr DG, Fibiger HC, Phillips AG (1989) Conditioned place preference as a measure of drug reward. In: The Neuropharmacological Basis of Reward (Liebman JM, Cooper SJ, Eds). Oxford University Press, Oxford, UK. p. 264-319.
• Cenci MA, Kalen P, Mandel RJ, Bjorklund A (1992) Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat. Brain Res 581: 217-228.
• Chiang YC, Chen PC, Chen JC (2003) D(3) dopamine receptors are down-regulated in amphetamine sensitized rats and their putative antagonists modulate the locomo¬tor sensitization to amphetamine. Brain Res 972: 159¬167.
• Cohen C, Sanger DJ, Perrault G (1997) Characterization of the discriminative stimulus produced by the dopamine antagonist tiapride. J Pharmacol Exp Ther 283: 566¬573.
• Coizet V, Dommett EJ, Klop EM, Redgrave P, Overton PG (2010) The parabrachial nucleus is a critical link in the transmission of short latency nociceptive information to midbrain dopaminergic neurons. Neuroscience 168: 263¬272.
• Cooper BR, Howard JL, Grant LD, Smith RD, Breese GR (1974) Alteration of avoidance and ingestive behavior after destruction of central catecholamine pathways with 6-hydroxydopamine. Pharmacol Biochem Behav 2: 639¬649.
• D'Angio M, Serrano A, Rivy JP, Scatton B (1987) Tail-pinch stress increases extracellular DOPAC levels (as measured by in vivo voltammetry) in the rat nucleus accumbens but not frontal cortex: antagonism by diazepam and zolpidem. Brain Res 409: 169-174.
• Deminiere JM, Piazza PV, Guegan G, Abrous N, Maccari S, Le Moal M, Simon H (1992) Increased locomotor response to novelty and propensity to intravenous amphet¬amine self-administration in adult offspring of stressed mothers. Brain Res 586: 135-139.
• Dettmar PW, Cowan A, Walter CS (1978) Naloxone antago¬nizes behavioral effects of d-amphetamine in mice and rats. Neuropharmacology 17: 1041-1044.
• Deutch AY, Tam RH (1985) Footshock and conditioned stress increase 3,4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigra. Brain Res 333: 143-146.
• DiChiara G, Loddo P, Tanda G (1999) Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: Implications for the psychobiology of depression. Biol Psychiatry 46: 1624-1633.
• DiScala G, Sandner G (1989) Conditioned place aversion produced by FG 7142 is attenuated by haloperidol. Psychopharmacology 99: 176-180.
• Doherty MD, Gratton A (1997) NMDA receptors in nucleus accumbens modulate stress-induced dopamine release in nucleus accumbens and ventral tegmental area. Synapse 26: 225-234.
• Emmanouil DE, Quock RM (1990) Effects of benzodiazepine agonist, inverse agonist and antagonist drugs in the mouse staircase test. Psychopharmacology 102: 95-97.
• Fenu S, Bassareo V, DiChiara G (2001) A role for dopamine D1 receptors of the nucleus accumbens shell in condi¬tioned taste aversion learning. J Neurosci 21: 6897¬6904.
• Ferssiwi A, Cardo B, Velley L (1987) Electrical self-stimu¬lation in the parabrachial area is depressed after ibotenic acid lesion of the lateral hypothalamus. Behav Brain Res 25: 109-116.
• Flagel SB, Clark JJ, Robinson TE, Mayo L, Czuj A, Willuhn I, Akers CA, Clinton SM, Phillips PE, Akil H (2011) A selective role for dopamine in stimulus-reward learning. Nature 469: 53-57.
• Fuchs H, Nagel J, Hauber W (2005) Effects of physiological and pharmacological stimuli on dopamine release in the rat globus pallidus. Neurochem Int 47: 474-481.
• Fulwiler CE, Saper CB (1984) Subnuclear organization of the efferent connections of the parabrachial nucleus in the rat. Brain Res 7: 229-259.
• Garris PA, Kilpatrick M, Bunin MA, Michael C, Walker QD, Wightman RM (1999) Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimula¬tion. Nature 398: 67-69.
• Gauriau C, Bernard JF (2001) Pain pathways and parabra¬chial circuits in the rat. Exp Physiol 87: 251-258.
• Gratton A, Wise RA (1983) Brain stimulation reward in the lateral hypothalamic medial forebrain bun¬dle: mapping of boundaries and homogeneity. Brain Res 274: 25-30.
• Hawkins RD, Roll PL, Puerto A, Yeomans JS (1983) Refractory periods of neurons mediating stimulation- elicited eating and brain stimulation reward: interval scale measurement and tests of a model of neural integra¬tion. Behav Neurosci 97: 416-432.
• Hoebel BG (1976) Brain-stimulation reward and aversion in relation to behavior. In: Brain-Stimulation Reward (Wauquier A, Rolls ET, Ed.). North-Holland Publishing Company, Amsterdam, NL. p. 335-372.
• Hoebel BG, Avena NM, Rada P (2007) Accumbens dopamine-acetylcholine balance in approach and avoidance. Curr Opin Pharmacol 7: 617-627.
• Ikemoto S, Panksepp J (1999) The role of nucleus accum¬bens dopamine in motivated behavior: a unifying inter¬pretation with special reference to reward-seeking. Brain Res 31: 6-41.
• Imperato A, Angelucci L, Casolini P, Zocchi A, Puglisi- Allegra S (1992) Repeated stressful experiences differ¬ently affect limbic dopamine release during and follow¬ing stress. Brain Res 577: 194-199.
• Jasmin L, Boudah A, Ohara PT (2003) Long-term effects of decreased central nervous system and opioid antinociception. J Comp Neurol 460: 38-55.
• Joyce EM, Iversen SD (1979) The effect of morphine applied locally to mesencephalic dopamine cell bodies on spontaneous motor activity in the rat. Neuroscience Lett 14: 207-212.
• Lorden JF, Callahan M, Dawson R (1980) Depletion of cen¬tral catecholamines alters amphetamine- and fenflu- ramine-induced taste aversions in the rat. J Comp Physiol Psychol 94: 99-114.
• Lundry RF, Norgren R (2004) Gustatory System. In: The Rat Nervous System (Paxinos G, Ed.), Elsevier Academic Press, San Diego, CA. p. 891-921.
• Mansour A, Fox CA, Akil H, Watson SJ (1995) Opioid- receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci 18: 22-29.
• Mayer DJ, Wolfle TL, Akil H, Carder B, Liebeskind JC (1971) Analgesia from electrical stimulation in the brain- stem of the rat. Science 174: 1351-1354.
• McCullough LD, Salamone JD (1992) Anxiogenic drug beta-CCE and FG7142 increase extracellular dopamine levels in nucleus accumbens. Psychopharmacology 109: 379-382.
• McCullough LD, Sokolowski JD, Salamone JD (1993) A neurochemical and behavioral investigation of the involvement of nucleus accumbens dopamine in instru¬mental avoidance. Neuroscience 52: 919-925.
• Mediavilla C, Molina F, Puerto A (2000) The role of the lat¬eral parabrachial nuclei in concurrent and sequential taste aversion learning in rats. Exp Brain Res 134: 497-505.
• Mediavilla C, Molina F, Puerto A (2005) Concurrent condi¬tioned taste aversion: A learning mechanism based on rapid neural versus flexible humoral processing of visceral nox¬ious substances. Neurosci Biobehav Rev 29: 1107-1118.
• Mediavilla C, Bernal A, Mahia J, Puerto A (2011) Nucleus of the solitary tract and flavour aversion learning: rele¬vance in concurrent but not sequential behavioural test. Behav Brain Res 223: 287-292.
• Mediavilla C, Mahia J, Bernal A, Puerto A (2012) The D(2)/D(3)-receptor antagonist tiapride impairs concurrent but not sequential taste aversion learning. Brain Res Bull 87: 346-349.
• Milman A, Weizman R, Rigai T, Rice KC, Pick CG (2006) Behavioral effects of opioid subtypes compared with benzodiazepines in the staircase paradigm. Behav Brain Res 170: 141-147.
• Moufid-Bellancourt S, Razafimanalina R, Velley L (1996) Interaction between mu and kappa receptors located in the parabrachial area in the opioid control of preference threshold for saccharin: modulatory role of lateral hypo- thalamic neurones. Behav Pharmacol 7: 798-809.
• Nader K, Bechara A, van der Kooy D (1996) Lesions of the lateral parabrachial nucleus block the aversive motiva¬tional effects of both morphine and morphine withdrawal but spare morphine s discriminative properties. Behav Neurosci 110: 1496-1502.
• ODoherty JO, Kringelbach ML, Rolls ET, Hornak J, Andrews C (2001) Abstract reward and punishment rep¬resentations in the human orbitofrontal cortex. Nat Neurosci 4: 95-102.
• Paxinos G, Watson C (1998) The Rat Brain in Stereotaxic Coordinates. Academy Press, San Diego, CA.
• Pecina S, Berridge KC, Parker LA (1997) Pimozide does not shift palatability: Separation of anhedonia from senso- rimotor suppression by taste reactivity. Pharmacol Biochem Behav 58: 801-811.
• Phillips PE, Stuber GD, Helen MLAV, Wightman RM, Carelli RM (2003) Subsecond dopamine release promotes cocaine seeking. Nature 422: 614-618.
• Poon CS (2009) Optimal interaction of respiratory and ther¬mal regulation at rest and during exercise: role of a sero¬tonin-gated spinoparabrachial thermoafferent pathway. Respir Physiol Neurobiol 169: 234-242.
• Prado WA, Roberts MH (1985) An assessment of the anti- nociceptive and aversive effects of stimulating identified sites in the rat brain. Brain Res 340: 219-228.
• Reilly S, Trifunovic R (2000) Lateral parabrachial nucleus lesions in the rat: Aversive and appetitive gustatory con¬ditioning. Brain Res Bull 52: 269-278.
• Robinson S, Sandstrom SM, Denenberg VH, Palmiter RD (2005) Distinguishing whether dopamine regulates lik¬ing, wanting and/or learning about reward. Behav Neurosci 119: 5-15.
• Roitman MF, Stuber GD, Phillips PE, Wightman PM, Carelli RM (2004) Dopamine operates as a subsecond modulator of food seeking. J Neurosci 24: 1265-1271.
• Sakai N, Yamamoto T (1997) Conditioned taste aversión and c-fos expresion in the rat brainstem after administration of varios U.S.s. NeuroReport 8: 2215-2220.
• Sakai N, Yamamoto T (1998) Role of the medial and lateral parabrachial nucleus in acquisition and retention of con¬ditioned taste aversion in rats. Behav Brain Res 93: 63-70.
• Salamone JD (1988) Dopaminergic involvement in activa- tional aspect of motivation: Effects of haloperidol on schedule-induced activity, feeding and foraging in rats. Psychobiology 16: 196-206.
• Salamone JD (1992) Complex motor and sensorimotor func¬tions of striatal and accumbens dopamine: involvement in instrumental behavior processes. Psychopharmacology 107: 160-174.
• Salamone JD (1994) The involvement of nucleus accumbens dopamine in appetitive and aversive motivation. Behav Brain Res 61: 117-133.
• Sanger DJ (1987) The actions of SCH 23390, a D1 receptor antagonist, on operant and avoidance behavior in rats. Pharmacol Biochem Behav 26: 509-513.
• Santi AN, Parker LA (2001) The dopamine antagonist, alpha-flupenthixol, interferes with naloxone-induced place aversion learning, but not with acute opiate depen¬dence in rats. Pharmacol Biochem Behav 70: 193-197.
• Scatton B, Cohen C, Perrault G, Oblin A, Claustre Y, Schoemaker H, Sanger DJ, Rouquier L, Porsolt R (2001) The preclinical pharmacologic profile of tiapride. Eur Psychiatry 16: 29s-34s.
• Schachter SC (2004) Vagus nerve stimulation: mood and cognitive effects. Epilepsy Behav 5: 56-59.
• Schachter SC, Saper CB (1998) Progress in epilepsy research. Vagus nerve stimulation. Epilepsia 39: 677¬686.
• Schildein S, Agmo A, Huston JP, Schwarting RKW (1998) Intraaccumbens injections of substance P, morphine and amphetamine: effects on conditioned place preference and behavioural activity. Brain Res 790: 185-194.
• Simón MJ, García R, Zafra MA, Molina F, Puerto A (2007) Learned preferences induced by electrical stimulation of a food-related area of the parabrachial complex: effects of naloxone. Neurobiol Learn Mem 87: 332-342.
• Simón MJ, Zafra MA, Molina F, Puerto A (2008) Consistent rewarding or aversive effects of the electrical stimulation of the lateral parabrachial complex. Behav Brain Res 190: 67-73.
• Simón MJ, Molina F, Puerto A (2009) Conditioned place preference but not rewarding self-stimulation after elec¬trical activation of the external lateral parabrachial nucle¬us. Behav Brain Res 205: 443-449.
• Smith JW, Fetsko LA, Xu R, Wang Y (2002) Dopamine D2L receptor knockout mice display deficits in positive and negative reinforcing properties of morphine and in avoid¬ance learning. Neuroscience 113: 755-765.
• Soares KV, McGrath JJ (1999) The treatment of tardive dyskinesia--a systematic review and meta-analysis. Schizophr Res 39: 1-16.
• Soyka M, Morhart-Klute V, Horak M (2002) A combination of carbamazepine/tiapride in outpatient alcohol detoxifi¬cation. Results from an open clinical study. Eur Arch Psychiatry Clin Neurosci 252: 197-200.
• Thierry AM, Tassin JP, Blanc G, Glowinski J (1976) Selective activation of the mesocortical DA system by stress. Nature 263: 242-263.
• Tokita K, Shimura T, Nakamura S, Inoue T, Yamamoto T (2007) Involvement of forebrain in parabrachial neuronal activation induced by aversively conditioned taste stimu¬li in the rat. Brain Res 1141: 188-196.
• White IM, Ciancone MT, Haracz JL, Rebec GV (1992) A lever-release version of the conditioned avoidance response paradigm: Effects of haloperidol, clozapine, sulpiride, and BMY-14802. Pharmacol Biochem Behav 41: 29-35.
• Wilkinson LS, Humby T, Killcross AS, Torres EM, Everitt BJ, Robbins TW (1998) Dissociations in dopamine release in medial prefrontal cortex and ventral striatum during the acquisition and extinction of classical aversive conditioning in the rat. Eur J Neurosci 10: 1019-1026.
• Yamamoto T, Matsuo R, Kiyomitsu Y, Kitamura R (1989) Taste responses of cortical neurons in freely ingesting rats. J Neurophysiol 61: 1244-1258.
• Yamamoto T, Shimura T, Sakai N, Ozaki N (1994a) Representation of hedonics and quality of taste stimuli in the parabrachial nucleus of the rat. Physiol Behav 56: 1197-1202.
• Yamamoto T, Shimura T, Sako N, Yasoshima Y, Sakai N (1994b) Neural substrates for conditioned taste aversion in the rat. Behav Brain Res 65: 123-137.
• Yeomans JS (1990) "Temporal summation decay" in hypo¬thalamic self-stimulation: threshold changes at long intra- pair intervals due to axonal subnormal periods. Behav Neurosci 104: 991-999.
• Young AMJ, Moran PM, Joseph MH (2005) The role of dopamine in conditioning and latent inhibition: What, when, where and how? Neurosci Biobehav Rev 29: 963-976.
• Zafra MA, Simón MJ, Molina F, Puerto A (2002) The role of the external lateral parabrachial subnucleus in flavor pref¬erences induced by predigested food administered intra- gastrically. Brain Res 950: 155-164.
• Zafra MA, Simón MJ, Molina F, Puerto A (2005) Lesions of the lateral parabrachial area block the aversive compo¬nent and induced-flavor preference for the delayed intra¬gastric administration of nutrients in rats: effects on sub¬sequent food and water intake. Nutr Neurosci 8: 297¬307.
• Zito KA, Bechara A, Greenwood C, Van Der Kooy D (1988) The dopamine innervation of the visceral cortex mediates the aversive effects of opiates. Pharmacol Biochem Behav 30: 693-699.