Clock-controlled daily remodeling of neurons and synaptic contacts in the visual system of drosophila

• Autorzy: Pyza E. , Gorska-Andrzejczak J. , Damulewicz M.
• Języki publikacji: EN

Abstrakty

EN

In the first optic neuropil (lamina) of the visual system of Drosophila melanogaster, the first order interneurons receive photic and visual inputs from the overlying retina photoreceptors. Next they filtrate, enhance and transmit this information to the second optic neuropil (medulla). The inputs from the photoreceptors are transmitted by means of tetrad synapses, using histamine as a neurotransmitter, to 2-3 lamina interneurons, glial and amacrine cells. Among the lamina interneurons, L1 and L2 monopolar cells show circadian morphological plasticity. Their axons swell at the beginning of both the day and night and shrink at other times of the day. These changes in neurons are offset by morphological changes of glia in the lamina. The pattern of size changes of L1 and L2 axons is correlated with the pattern of D. melanogaster locomotor activity, which has two peaks, in the morning and in the evening. Moreover, the tetrad synapses in the lamina show similar structural oscillations, however, the rhythm in abundance of a presynaptic protein Bruchpilot (BRP) in the photoreceptor terminals is only maintained in a day/night (LD) regime but not in constant darkness (DD). It means that the density of tetrad presynaptic elements depends on light. In contrast to the presynaptic elements of tetrad synapses, their postsynaptic partners, dendrites of the L2 monopolar cells, change their structure not only in LD but also in DD. They are largest at the beginning of day. It indicates that the number of presynaptic elements of the tetrad synapses is regulated by direct exposure of light while organization of the postsynaptic sites is controlled by a circadian clock. In result circadian morphological plasticity of the L2 dendrites is light independent and driven by a circadian input from the circadian clock located in the brain.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: S
• Opis fizyczny: p.29

Twórcy

autor

Pyza E.

• Department of Cell Biology and Imaging, Jagiellonian University, Krakow, Poland

autor

Gorska-Andrzejczak J.

• Department of Cell Biology and Imaging, Jagiellonian University, Krakow, Poland

autor

Damulewicz M.

• Department of Cell Biology and Imaging, Jagiellonian University, Krakow, Poland

Uwagi

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