Sensory, motor and cognitive aspects of cerebellar control over the whisker system

• Autorzy: Bosman L.W.J. , Lindeman S. , Spanke J. K. , Ju C. , Owens C. B. , Negrello M. , Koekkoek S. K. E. , De Zeeuw C. J.
• Języki publikacji: EN

Abstrakty

EN

Mice rely on whiskers to orient themselves in the environment and to determine position, size and texture of objects. They have large whiskers that can be moved rhythmically. In line with its behavioral importance, a substantial part of the brain is devoted to the whisker system. Most attention has been paid to ascending trigemino-thalamo-cortical pathways and descending pathways from motor cortex to brainstem, but many other brain regions are also part of the whisker system: I will discuss sensory, motor and cognitive roles of the cerebellum, a crucial organ for sensorimotor control. The cerebellum receives strong whisker input, directly via the brainstem and indirectly via the cerebral cortex. The spatial and temporal organization of whisker input to the cerebellum will be discussed as well as the cerebellar impact on whisker movement. This will be shown in electrophysiological recordings in awake mice. Finally, we demonstrate that mutant mice specifically impaired in synaptic and intrinsic plasticity of cerebellar Purkinje cells have severe problems learning a whisker based object localization task, showing that the cerebellum is also important for cognitive aspects of behavior.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.348

Twórcy

autor

Bosman L.W.J.

• Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands

autor

Lindeman S.

• Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands

autor

Spanke J. K.

• Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
• Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Amsterdam, The Netherlands

autor

Ju C.

• Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands

autor

Owens C. B.

• Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands

autor

Negrello M.

• Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands

autor

Koekkoek S. K. E.

• Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands

autor

De Zeeuw C. J.

• Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
• Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Amsterdam, The Netherlands