Pharmacokinetic disposition of pethidine under tolerance

• Autorzy: Szczawinska K. , Cenajek-Musial D. , Nowakowska E. , Chodera A.
• Języki publikacji: EN

Abstrakty

EN

Szczawińska, K., Cenajek-Musiał, D., Nowakowska, E. and Chodera, A.: Pharmacokinetic disposition of pethidine under tolerance. Acta physiol pol., 1989, 40 (4): 374-380. Under tolerance, evoked by multiple doses of pethidine (PD), the serum and brain tissue content of PD was related to diminished analgesic activity. Even though in tolerant rats no enhancement of PD biotransformation in the liver could be recognized (as followed by the measurement of hepatic esterase and N-demethylase activity), the amounts of both PD and nor-PD excreted in urine were increased under tolerance. The authors conclude that the faster disposition of PD may contribute to the development of tolerance.

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1989
• Tom: 40
• Numer: 4
• Opis fizyczny: p.374-380,fig.,ref.

Twórcy

autor

Szczawinska K.

• Department of Pharmacology, School of Medicine, Poznan, Poland

autor

Cenajek-Musial D.

• Department of Pharmacology, School of Medicine, Poznan, Poland

autor

Nowakowska E.

• Department of Pharmacology, School of Medicine, Poznan, Poland

autor

Chodera A.

• Department of Pharmacology, School of Medicine, Poznan, Poland

Bibliografia

• 1. Axelrod, I. (1956) The enzymatic N-demethylation of narcotic drugs. J. Pharmacol. 117. 322-350.
• 2. Cenajek, D., Szczawińska, K., Chodera, A., Nowakowska, E. (1980) Development of tolerance to pethidine in rats pretreated or not with ß-naphtoflavone or SKF 525A. Acta physiol, pol. 39. 000-000.
• 3. Chan, K., Kendall, M. J., Wells, W. D. E., Mitchard, M. (.1975) Factors influencing the excretion and relative physiological availability of pethidine in man. J. Pharm. Pharmacol. 27. 235-241.
• 4. Clouet, D. H. (1964) Meperidine N-demethylase activity in rat liver. J. Pharmacol. Exp. Ther. 144. 354-361.
• 5. Cook, L., Naris, G., Toner, J., Fellows, E. J. (1953) Potentiation of certain analgesic drugs by ß-ethylaminodthyldiphenylpropylacetate hydrochloride (SKF no. 525A). Fed. Proc. 12. 313-317.
• 6. Herken, H. D., Heubert, D., Timmler, R. (1959) Die enzymatische N-Demethylierung durch Leber-Mikrosomen bei der Morphingewöhnung. Arch. exp. Pathol. Pharmacol. 237. 319-333.
• 7. Isbell, H,, White, W. M. (1953) Clinical characteristics of addictions. Amer. J. Med. 14. 558-565.
• 8. Kuschinsky, K. (1977) Opiate dependence. G. Fischer Verl., Stuttgart-New York.
• 9. Lowry, O. A., Rosenbrough, N. J., Fahr, A. L., Randall, R. J. (1951) Protein measurement with the Folin-phenol reagent. J. Biol. Chem. 193. 265-275.
• 10. Mazel, P. (1972) Experiments illustrating drug metabolism in vitro. In Fundamentals of Drug Metabolism and Disposition. Ed. B. N. LaDu, H. G. Mandel, E. L. Way, The Williams and Wilkins Co, Baltimore, 546-548.
• 11. Miller, J. W., Anderson, H. H. (1954) The effect of N-demethylation on certain pharmacologic actions of morphine, codeine and meperidine in the mouse. J. Pharmacol. Exp. Pharm. 112. 191-196.
• 12. Milthers, K. (1962) N-dealkylation of morphine and nalorphine in the brain of living rats. Nature (Berlin) 195. 607.
• 13. Nash, T. (1952) The colorimethic estimation of formaldehyde by means of the Hantzsch reaction. J. Biol. Chem. 55. 412-416.
• 14. Nowakowska, E., Chodera, A., Szczawińska, K., Cenajek, D. (1986) Effects of pethidine on central neurotransmitters: changes in the state of tolerance. Pol. J. Pharmacol. Pharm. 38. 143-148.
• 15. La Rosa, C., Morgan, D. J., Mather, L. E. (1984) Pethidine binding in whole blood: methodology and clinical significance. Brit. J. Clin. Pharmacol. 17. 405-409.
• 16. Stambaugh, J. E. Wainer, I. W. (1975). The bioavailability of meperidine using urine assays for mepefidine and normeperidine. J. Clin. Pharmacol. 15. 269-278.
• 17. Stambaugh, J. E., Wainer, I. W., Sanstead, J. K., Hemphill, D. M. (1976) The clinical pharmacology of meperidine - comparison of routes of administration. J. Clin. Pharmacol. 16. 245-256.
• 18. Yeh, S. Y. (1982) Localization and characterization of meperidine esterase of rats. Drug Metab. Disp. 10. 319-325.