The involvement of the CB2 agonist in the behavioral and biochemical effects in the experimental animal models

• Autorzy: Kruk-Slomka M. , Budzynska B. , Boguszewska-Cubara A. , Biala G.
• Języki publikacji: EN

Abstrakty

EN

Cannabinoids are implicated in regulation of variety emotions through the type 1 (CB1) and type 2 (CB2) receptors. Our pharamcological interests have been focused on the effects of CB2 receptor selective ligands in the treatment of Alzheimer disease (AD) which is associated with memory-loss, phobia, depression as well as oxidative processes in brain. We examined the impact of CB2 agonist: JWH-133 in mice using passive avoidance (PA) test to measure memory-related responses, elevated plus maze (EPM) test to measure anxiety-related behavior and forced swimming test (FST) to measure depression-related responses. Total antioxidant capacity (TAC) and lipids peroxidation level, expressed as malondialdehyde (MDA) concentration, were measured in homogenates of brain. Our findings revealed that a single injection of JWH-133 improved memory in PA, had an anxiogenic effects in EPM, antidepressant effects in FST and slightly increased total antioxidant capacity but did not affect lipids peroxidation level in brain. CB2 ligands could become a new pharmacological alternative in treatment of AD which is associated not only with emotional-related disorders but also with oxidative stress.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.364

Twórcy

autor

Kruk-Slomka M.

• Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Budzynska B.

• Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Boguszewska-Cubara A.

• Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland

autor

Biala G.

• Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland