Genes controlling 2-deoxyglucose induced lysis and formation of reactive oxygen species in Schizosaccharomyces pombe

• Autorzy: Vishwanatha A. , D Souza C.J.M. , Schweingruber M.E.
• Języki publikacji: EN

Abstrakty

EN

Schizosaccharomyces pombe cells of strains each carrying a deletion of one of the genes snf5, ypa1, pho7 and pas1 and of a strain overexpressing gene odr1, have been previously shown to grow in presence of the toxic glucose analogue 2-deoxyglucose (2-DG). Here we report that these genes control 2-DG induced lysis and are, with the exception of odr1, also involved in control of formation of reactive oxygen species (ROS) upon exposure of cells to H₂O₂. Lysis of deletion strains, but not of strain overexpressing odr1, is dependent on glucose concentration of the medium whereas ROS formation is glucose independent.

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2017
• Tom: 66
• Numer: 3
• Opis fizyczny: p.393-396,fig.,ref.

Twórcy

autor

Vishwanatha A.

• Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India

autor

D Souza C.J.M.

• Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India

autor

Schweingruber M.E.

• Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India

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Identyfikatory

DOI

10.5604/01.3001.0010.4877