Influence of antidepressants on LPS-induced brain-derived neurotrophic factor in hippocampus of female rats subjected to chronic social instability stress

• Autorzy: Nowacka M. , Paul-Samojedny M. , Bielecka A. , Obuchowicz E.
• Języki publikacji: EN

Abstrakty

EN

It is widely accepted that chronic stress leads to the development of, and is associated with, mood disorders. Exposure to stress may intensify consequences of neuroinflammation which is considered as a crucial mechanism leading to CNS injury involving the neuroanatomical alterations in hippocampus – structure play a significant role for mechanism of action of antidepressants. Chronic treatment with some antidepressants up-regulate expression of BDNF which is the key neurotrophic factor promoting cell survival and neuroplasticity. The study was carried out to investigate the influence of desipramine, fluoxetine or tianeptine given chronically on the lipopolysaccharide (LPS) effect on the expression and the level of BDNF in hippocampus of female rats subjected to chronic stress. In the hippocampus of LPS-treated rats subjected to chronic stress, BDNF mRNA and protein levels were reduced, in comparison to the stress-group. The LPS effect was protected by treatment with studied antidepressants. The protection of BDNF against the deleterous synergistic effect induced by inflammation and chronic stress may have significance for therapeutic effects of long-term treatment with antidepressants.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.27

Twórcy

autor

Nowacka M.

• Department of Pharmacology, Medical University of Silesia, Katowice, Poland
• Center for Experimental Mediciney, Medical University of Silesia, Katowice, Poland

autor

Paul-Samojedny M.

• Department of Medical Genetics, Medical University of Silesia, Katowice, Poland

autor

Bielecka A.

• Department of Pharmacology, Medical University of Silesia, Katowice, Poland

autor

Obuchowicz E.

• Department of Pharmacology, Medical University of Silesia, Katowice, Poland