Alkaloids biosynthesis by Pancratium maritimum L. shoots in liquid culture

• Autorzy: Georgiev V. , Ivanov I. , Berkov S. , Pavlov A.
• Języki publikacji: EN

Abstrakty

EN

The process of alkaloid biosynthesis by Pancratium maritimum shoot culture, cultivated under submerged conditions, was investigated. Twenty-two compounds of different structural types of the Amaryllidaceae alkaloids (tyramine, narciclasine, galanthamine, haemanthamine, lycorine, pancracine, tazettine and homolycorine types) were detected in the studied samples from biomass and cultural liquid. Dominant compounds in the shoots were of tyramine, lycorine and haemanthamine types, whereas in the culture media were found mainly lycorine type compounds. Based on the multi-metabolic estimation of the alkaloid metabolism and physiological peculiarities, liquid cultures of P. maritimum shoots could be defined as prospective biological systems for producing bioactive molecules with acetylcholinesterase inhibitory and apoptotic activities.

• Wydawca: -
• Czasopismo: Acta Physiologiae Plantarum
• Rocznik: 2011
• Tom: 33
• Numer: 3
• Opis fizyczny: p.927-933,fig.,ref.

Twórcy

autor

Georgiev V.

• Laboratory of Applied Biotechnologies, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria

autor

Ivanov I.

• Laboratory of Applied Biotechnologies, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria

autor

Berkov S.

• AgroBioInstitute, 8 Dragan Tzankov Blvd., 1164 Sofia, Bulgaria

autor

Pavlov A.

• Laboratory of Applied Biotechnologies, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria

Bibliografia

• Abbassy M, Gougery O, El-Hamady S, Sholo M (1998) Insecticidal, acaricidal and synergistic effects of soosan, Pancratium maritimum extracts and constituents. J Egypt Soc Parasitol 28:197–205
• Abou-Donia A, Giulio A, Evidente A, Gaber M, Habib AA, Lanzetta R, El-Din A (1991) Narciclastine-4-O-β-D-glucopyranoside, a glucosyloxy amidic phenantridone derivate from Pancratium maritimum. Phytochemistry 30:3445–3448
• Abou-Donia AH, Amer ME, Darwish FA, Kassem FF, Hammoda HM, Abdel-Kader MS, Zhou B-N, Kingston DGI (2002) Two new alkaloids of the crinane series from Pancratium sickenbergeri. Planta Med 68(4):379–381
• Bastida J, Lavilla R, Viladomat F (2006) Chemical and biological aspects of Narcissus alkaloids. In: Cordell GA (ed) The alkaloids, vol 63. Elsivier Scientific, Amsterdam, pp 87–179
• Berkov S, Evstatieva L, Popov S (2004) Alkaloids in Bulgarian Pancratium maritimum L. Z Naturforsch 59c:65–69
• Berkov S, Bastida J, Sidjimova B, Viladomat F, Codina C (2008) Phytochemical differentiation of Galanthus nivalis and Galanthus elwesii (Amaryllidaceae): a case study. Biochem System Ecol 36:638–645
• Cedron J, Oberti J, Estevez-Braun A, Ravelo A, Arco-Angular M, Lopez M (2009) Pancratium canariense as an important source of Amaryllidaceae alkaloids. J Nat Prod 72:112–116
• Evidente A, Kornienko A (2009) Anticancer evaluation of structurally diverse Amaryllidaceae alkaloids and their synthetic derivates. Phytochem Rev 8:449–459
• Georgiev V, Ilieva M, Bley Th, Pavlov A (2008) Betalain production in plant in vitro systems. Acta Physiol Plant 30:581–593
• Houghton P, Ren Y, Howes MJ (2006) Acetylcholinesterase inhibitors from plants and fungi. Nat Prod Rep 23:181–199
• Huerta-Heredia AA, Marin-Lopez R, Ponce-Noyola T, Cerda-Garcia-Rojas CM, Trejo-Tapia G, Ramos-Valdivia AC (2009) Oxidative stress induces alkaloid production in Urcaria tomentosa root and cell cultures in bioreactors. Eng Life Sci 9:211–218
• Iordanov D (1964) Genus Pancratium. In: Iordanov D (ed) Flora of People’s Republic of Bulgaria, vol 2. Academic Press, Sofia, pp 323–324
• Kinghorn AD, Chin YW, Swanson SM (2009) Discovery of natural product anticancer agents from biodiverse organisms. Curr Opinion Drug Disc Develop 12(2):189–196
• Kintsurashvili L, Vachnadze V (2007) Plants of the Amaryllidaceae family grown and introduced in Georgia: a source of galanthamine. Pharm Chem J 41(9):492–494
• Liua J, Hua WX, Heb LF, Yec M, Lia Y (2004) Effects of lycorine on HL-60 cells via arresting cell cycle and inducing apoptosis. FEBS Lett 578:245–250
• Lopez S, Bastida J, Viladomat F, Codina C (2002) Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts. Life Sci 71:2521–2529
• Maelicke A, Samochocki M, Jostok R, Feherbacker A, Ludwig J, Albuquerque EX, Zerlin M (2001) Allosteric sensitation of niconinic receptors by galanthamine, a new treatment strategy for Alzheimer’s disease. Biol Psychiat 26:279–288
• McNulty J, Nair JJ, Bastida J, Pandey S, Griffin C (2009) Structureactivity studies on the lycorine pharmacophore: a potent inducer of apoptosis in human leukemia cells. Phytochemistry 70:913–919
• Medrano M, Guitian P, Guitian J (1999) Breeding system and temporaral variation in fecundity of Pancratium maritimum L. (Amaryllidaceae). Flora 194:13–19
• Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15:473–479
• Orhan I, Sener B (2003) Bioactivity-directed fractionation of alkaloids from some Amaryllidaceae plants and their anticholinesterase activity. Chem Nat Comp 39(4):383–386
• Pavlov A, Popov S, Kovacheva E, Georgiev M, Ilieva M (2005) Volatile and polar compounds in Rosa damascena Mill 1803 cell suspension. J Biotechnol 118:89–97
• Pavlov A, Berkov S, Courot E, Gocheva T, Tuneva D, Pandova B, Georgiev M, Georgiev V, Yahev S, Burrus M, Ilieva M (2007) Galanthamine production by Leucojum aestivum in vitro systems. Proc Biochem 42:734–739
• Perry NSL, Noughton PJ, Theobald AE, Jenner P, Perry EK (2000) In vitro inhibition of human erythrocyte acetylcholine esterase by Salvia lavandulaefolia essential oil and constituent terpenes. J Pharm Pharmacol 52:895–902
• Sandberg F, Michel KH (1968) Alkaloids of Pancratium maritimum. Acta Pharm Suec 5:61–66
• Senar B, Konucol S, Kruk C, Pandit U (1993) New crinine type alkaloids from Pancratium maritimum growing in Turkey. Nat Prod Lett 1:287–291
• Senar B, Konucol S, Kruk C, Pandit U (1994) Alkaloids of Amaryllidaceae II. Alkaloids of crinine class from Pancratium maritimum. J Chem Soc Pak 16:275–279
• Senar B, Konucol S, Kruk C, Pandit U (1998) Alkaloids of Amaryllidaceae III. Alkaloids from the bulbs of Pancratium maritimum. Nat Prod Sci 4:148–152
• Sener B, Orhan I (2005) Discovery of drug candidates from some Turkish plants and conservation of biodiversity. Pure Appl Chem 77(1):53–64
• Sur-Altiner D, Gurkan E, Mutlu G, Tuzlaci E, Ang O (1999) The antifungal activity of Pancratium maritimum. Fitoterapia 70:187–189
• Tato P, Castedo L, Riguera R (1998) New alkaloids from Pancratium maritimum. Heterocycles 27:2833–2838
• Torras-Claveria L, Berkov S, Jauregui O, Caujape J, Viladomat F, Codina C, Bastida J (2010) Metabolic profiling of bioactive Pancratium canariense extracts by GC–MS. Phytochem Anal 21(1):80–88
• Zhong JJ (2001) Biochemical engineering of the production of plantspecific secondary metabolites by cell suspension cultures. In: Scheper T, Zhong JJ (eds) Advances in biochemical engineering/ biotechnology. Plant Cells, Springer, Heidelberg, pp 1–26

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