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2015 | 61 | 1 |
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The efficacy of topical and oral ivermectin in the treatment of human scabies

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Scabies is an itchy skin condition caused by the microscopic mite Sarcoptes scabei. The itching is caused by an allergic reaction to the mites. The treatment of choice is still controversial. It is commonly treated with topical insecticides. The aim of this study was to assess the efficacy of topical and oral ivermectin in the treatment of human scabies. We searched electronic databases (Cochrane Occupational Safety and Health Review Group Specialised Register, CENTRAL (The Cochrane Library), MEDLINE (Ovid), Pubmed, EMBASE, LILACS, CINAHL, Open Grey and WHO ICTRP) up to September 2014. Randomized controlled trials (RCTs) or cluster RCTs which compared the efficacy of ivermectin with other medications in the treatment of scabies. Interventions could be compared to each other, or to placebo or to no treatment. The author intended to extract dichotomous data (developed infection or did not develop infection) for the effects of interventions. We intended to report any adverse outcomes similarly. It has been sated that ivermectin was as effective as permethrin in the treatment of scabies. In comparison to other medications such as lindane, benzyl benzoate, crotamiton and malathion, ivermectin was more effective in the treatment of scabies. Ivermectin is an effective and cost-comparable alternative to topical agents in the treatment of scabies infection.
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Opis fizyczny
  • Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Teheran, Iran
  • Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Teheran, Iran
  • Tabriz University of Medical Sciences, Tabriz, Iran
  • [1] Manjhi P.K., Sinha R.I., Kumar M., Sinha K.I. 2014. Comparative study of efficacy of oral ivermectin versus some topical antiscabies drugs in the treatment of scabies. Journal of Clinical and Diagnostic Research 8: HC01-HC04.
  • [2] Fujimoto K., Kawasaki Y., Morimoto K., Kikuchi I., Kawana S. 2014. Treatment for crusted scabies: limitations and side effects of treatment with ivermectin. Journal of Nippon Medical School 81: 157-163.
  • [3] Sfeir M., Munoz-Price L.S. 2014. Scabies and bedbugs in hospital outbreaks. Current Infectious Disease Reports 16: 412.
  • [4] Berthe-Aucejo A., Prot-Labarthe S., Pull L., Lorrot M., Touratier S., Trout H. et al. 2014. Treatment of scabies and Ascabiol ((R)) supply disruption: what about the pediatric population? Archives of Pediatrics 21: 670-675 (In French).
  • [5] Pomares C., Marty P., Delaunay P. 2014. Isolated itching of the genitals. The American Journal of Tropical Medicine and Hygiene 90: 589-590.
  • [6] Casais R., Dalton K.P., Millan J., Balseiro A., Oleaga A., Solano P. et al. 2014. Primary and secondary experimental infestation of rabbits (Oryctolagus cuniculus) with Sarcoptes scabiei from a wild rabbit: factors determining resistance to reinfestation. Veterinary Parasitology 203: 173-183.
  • [7] Spadoni S., Lamand V., Vonesch M.A., Beranger C. 2014. Scabies: A world plague. Médecine et Santé Tropicales 24: 41-48 (In Italian).
  • [8] Maghrabi M.M., Lum S., Joba A.T., Meier M.J., Holmbeck R.J., Kennedy K. 2014. Norwegian crusted scabies: an unusual case presentation. Foot and Ankle Surgery 53: 62-66.
  • [9] Bitar D., Caumes E., Chandre F., Del G.P., Gehanno J.F., Le G.C. et al. 2013. Management of one or several cases of scabies. Archives of Pediatrics 20: 1358-1363.
  • [10] Haar K., Romani L., Filimone R., Kishore K., Tuicakau M., Koroivueta J. et al. 2014. Scabies community prevalence and mass drug administration in two Fijian villages. International Journal of Dermatology 53: 739-745.
  • [11] Davis J.S., McGloughlin S., Tong S.Y., Walton S.F., Currie B.J. 2013. A novel clinical grading scale to guide the management of crusted scabies. PLoS Neglected Tropical Diseases 7: e2387.
  • [12] Shimose L., Munoz-Price L.S. 2013. Diagnosis, prevention, and treatment of scabies. Current Infectious Disease Reports 15: 426-431.
  • [13] McLean F.E. 2013. The elimination of scabies: a task for our generation. International Journal of Dermatology 52: 1215-1223.
  • [14] Zuniga R., Nguyen T. 2013. Skin conditions: emerging drug-resistant skin infections and infestations FP Essentials 407: 17-23.
  • [15] Engelman D., Martin D.L., Hay R.J., Chosidow O., McCarthy J.S., Fuller L.C. et al. 2013. Opportunities to investigate the effects of ivermectin mass drug administration on scabies. Parasites and Vectors 6: 106.
  • [16] Ichikawa M., Tanaka M., Naritomi Y., Furue M. 2013. Combined ivermectin and topical therapy significantly reduces treatment time in aged scabietic patients. Journal of Dermatology 40: 306-307.
  • [17] Worth C., Heukelbach J., Fengler G., Walter B., Liesenfeld O., Hengge U et al. 2013. Acute morbidity associated with scabies and other ectoparasitoses rapidly improves after treatment with ivermectin. Pediatrics Dermatology 29: 430-436.
  • [18] Gonzalez P., Gonzalez F.A., Ueno K. 2012. Ivermectin in human medicine, an overview of the current status of its clinical applications. Current Pharmaceutical Biotechnology 130: 1103-1109.
  • [19] Lekimme M., Farnir F., Marechal F., Losson B. 2010. Failure of injectable ivermectin to control psoroptic mange in cattle. Veterinary Record 167: 575-576.
  • [20] Galvany R.L., Salleras R.M., Umbert M.P. 2010. Bullous scabies responding to ivermectin therapy. Actas Dermo-sifiliográficas 101: 81-84.
  • [21] Steer A.C., Kearns T., Andrews R.M., McCarthy J.S., Carapetis J.R., Currie B.J. 2009. Ivermectin worthy of further investigation. Bulletin of the World Health Organisation 87: A.
  • [22] Mounsey K.E., Holt D.C., McCarthy .J.S, Currie B.J., Walton S.F. 2009. Longitudinal evidence of increasing in vitro tolerance of scabies mites to ivermectin in scabies-endemic communities. Archives of Dermatology 145: 840-841.
  • [23] Nofal A. 2009. Variable response of crusted scabies to oral ivermectin: report on eight Egyptian patients. Journal of the European Academy of Dermatology and Venereology 23: 793-797.
  • [24] Twomey D.F., Birch E.S., Schock A. 2009. Outbreak of sarcoptic mange in alpacas (Vicugna pacos) and control with repeated subcutaneous ivermectin injections. Veterinary Parasitology 159: 186-191.
  • [25] Badiaga S., Foucault C., Rogier C., Doudier B., Rovery C., Dupont H.T. et al. 2008. The effect of a single dose of oral ivermectin on pruritus in the homeless. The Journal of Antimicrobial Chemotherapy 62: 404-409.
  • [26] Garcia C., Iglesias D., Terashima A., Canales M., Gotuzzo E. 2007. Use of ivermectin to treat an institutional outbreak of scabies in a low-resource setting. Infection Control and Hospital Epidemiology 28: 1337-1338.
  • [27] Chaurasia R.C. 2007. Ivermectin-antiscabies chemotherapeutic agent used in masses. Journal of the Indian Medical Association 105: 99.
  • [28] Fox L.M. 2006. Ivermectin: uses and impact 20 years on. Current Opinion in Infectious Diseases 19: 588-593.
  • [29] Guay D.R. 2004. The scourge of sarcoptes: oral ivermectin for scabies. The Consultant Pharmacist 19: 222-235.
  • [30] Ribeiro F.A., Taciro E., Guerra M.R., Eckley C.A. 2005. Oral ivermectin for the treatment and prophylaxis of scabies in prison. Journal of Dermatological Treatment 16: 138-141.
  • [31] Goldust M., Rezaee E., Raghifar R., Hemayat S. 2013. Treatment of scabies: the topical ivermectin vs. permethrin 2.5% cream. Annals of Parasitology 59: 79-84.
  • [32] Ranjkesh M.R., Naghili B., Goldust M., Rezaee E. 2013. The efficacy of permethrin 5% vs. oral ivermectin for the treatment of scabies. Annals of Parasitology 59: 189-194.
  • [33] Chhaiya S.B., Patel V.J., Dave J.N., Mehta D.S., Shah H.A. 2012. Comparative efficacy and safety of topical permethrin, topical ivermectin, and oral ivermectin in patients of uncomplicated scabies. Indian Journal of Dermatology, Venereology and Leprology 78: 605-610.
  • [34] Goldust M., Rezaee E., Hemayat S. 2012. Treatment of scabies: Comparison of permethrin 5% versus ivermectin. The Journal of Dermatology 39: 545-547.
  • [35] Sharma R., Singal A. 2011. Topical permethrin and oral ivermectin in the management of scabies: a prospective, randomized, double blind, controlled study. Indian Journal of Dermatology, Venereology and Leprology 77: 581-586.
  • [36] Paasch U., Haustein U.F. 2001. Treatment of endemic scabies with allethrin, permethrin and ivermectin. Evaluation of a treatment strategy. Hautarzt 52: 31-37 (In Deutsch).
  • [37] Paasch U., Haustein U.F. 2000. Management of endemic outbreaks of scabies with allethrin, permethrin, and ivermectin. International Journal of Dermatology 39: 463-470.
  • [38] Usha V., Gopalakrishnan Nair T.V. 2000. A comparative study of oral ivermectin and topical permethrin cream in the treatment of scabies. Journal of American Academy of Dermatology 42: 236-240.
  • [39] Currie B.J., McCarthy J.S. 2010. Permethrin and ivermectin for scabies. The New England Journal of Medicine 362: 717-725.
  • [40] Bachewar N.P., Thawani V.R., Mali S.N., Gharpure K.J., Shingade V.P., Dakhale G.N. 2009. Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies. Indian Journal of Pharmacology 41: 9-14.
  • [41] Elgart M.L. 2003. Cost-benefit analysis of ivermectin, permethrin and benzyl benzoate in the management of infantile and childhood scabies. Expert Opinion on Pharmacotherapy 4: 1521-1524.
  • [42] Abedin S., Narang M., Gandhi V., Narang S. 2007. Efficacy of permethrin cream and oral ivermectin in treatment of scabies. Indian Journal of Pediatrics 74: 915-916.
  • [43] Goldust M., Rezaee E., Raghifar R., Naghavi- Behzad M. 2013. Ivermectin vs. lindane in the treatment of scabies. Annals of Parasitology 59: 37- 41.
  • [44] Mohebbipour A., Saleh P., Goldust M., Amirnia M., Zadeh Y.J., Mohamad R.M. et al. 2013. Comparison of oral ivermectin vs. lindane lotion 1% for the treatment of scabies. Clinical and Experimental Dermatology 38: 719-723.
  • [45] Mohebbipour A., Saleh P., Goldust M., Amirnia M., Zadeh Y.J., Mohamadi R.M. et al. 2012. Treatment of scabies: comparison of ivermectin vs. lindane lotion 1%. Acta Dermatovenerologica Croatica 20: 251- 255.
  • [46] van den Hoek J.A., van de Weerd J.A., Baayen T.D., Molenaar P.M., Sonder G.J., van Ouwerkerk I.M. et al. 2008. A persistent problem with scabies in and outside a nursing home in Amsterdam: indications for resistance to lindane and ivermectin. Euro Sur vei - llance 13: 1-2.
  • [47] Madan V., Jaskiran K., Gupta U., Gupta D.K. 2001. Oral ivermectin in scabies patients: a comparison with 1% topical lindane lotion. The Journal of Dermatology 28: 481-484.
  • [48] Chouela E.N., Abeldano A.M., Pellerano G., La F.M., Papale R.M., Garsd A. et al. 1999. Equivalent therapeutic efficacy and safety of ivermectin and lindane in the treatment of human scabies. Archive of Dermatology 135: 651-655.
  • [49] Sule H.M., Thacher T.D. 2007. Comparison of ivermectin and benzyl benzoate lotion for scabies in Nigerian patients. The American Journal of Tropical Medicine and Hygiene 76: 392-395.
  • [50] Brooks P.A., Grace R.F. 2002. Ivermectin is better than benzyl benzoate for childhood scabies in developing countries. Journal of Paediatrics and Child Health 38: 401-404.
  • [51] Alberici F., Pagani L., Ratti G., Viale P. 2000. Ivermectin alone or in combination withbenzyl benzoate in the treatment of human immunodeficiency virus-associated scabies. British Journal of Dermatology 142: 969-972.
  • [52] Glaziou P., Cartel J.L., Alzieu P., Briot C., Moulia-Pelat J.P., Martin P.M. 1993. Comparison of ivermectin and benzyl benzoate for treatment of scabies. Tropical Medicine and Parasitology 44: 331- 332.
  • [53] Ly F., Caumes E., Ndaw C.A., Ndiaye B., Mahe A. 2009. Ivermectin versus benzyl benzoate applied once or twice to treat human scabies in Dakar, Senegal: a randomized controlled trial. Bulletin of the World Health Organisation 87: 424-430.
  • [54] Goldust M., Rezaee E., Raghiafar R. 2014. Topical ivermectin versus crotamiton cream 10% for the treatment of scabies. International Journal of Dermatology 53: 904-908.
  • [55] Goldust M., Rezaee E., Raghifar R. 2014. Comparison of oral ivermectin versus crotamiton 10% cream in the treatment of scabies. Cutaneous and Ocular Toxicology 33: 333-336.
  • [56] Goldust M., Rezaee E. 2013. The efficacy of topical ivermectin versus malation 0.5% lotion for the treatment of scabies. Journal of Dermatological Treatment doi:10.3109/09546634.2013.782093.
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