Platelets – an important element of the immune system

• Autorzy: Trzeciak-Ryczek A. , Tokarz-Deptula B. , Deptula W.
• Języki publikacji: EN

Abstrakty

EN

Platelets are anucleate cells derived from the megakaryocyte series, and have long been considered only as cells responsible for coagulation and the fibrinolysis process. However, recently more data shows that they are also effector cells in the inflammatory response and important elements of the immunological response. Platelets store and release many biologically active substances, including growth factors, cytokines and chemokines (tab. 1), which actively affect i.a. elements of the immune system, and thus become regulators of immunity and mediators of inflammatory response. Their impact on the immune system cells is also associated with the induction of leucocytes and progenitor cells to the site of pathogen permeation or vascular injury inflow, as well as endothelial cells. Interacting with neutrophils, monocytes and lymphocytes, they not only activate them, but also form platelet-leukocyte aggregates that immobilise pathogens and prevent their spreading. Furthermore, platelets are capable of absorbing pathogens, affecting anti-infection immunity of the system. It is also assumed that the presence of receptors on their surface, such as Toll-like receptors (TLRs), affects their initiation and activity of the immunological response.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2013
• Tom: 16
• Numer: 2
• Opis fizyczny: p.407-413,ref.

Twórcy

autor

Trzeciak-Ryczek A.

• Department of Immunology, University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland

autor

Tokarz-Deptula B.

• Department of Immunology, University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland

autor

Deptula W.

• Department of Microbiology, Faculty of Biology University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland

Bibliografia

• Blair P, Rex S, Vitseva O, Beaulieu L, Tanriverdi K, Chakrabarti S, Hayashi C, Genco CA, Iafrati M, Freedman JE (2009) Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. Circ Res 104: 346-354.
• Blumberg N, Spinelli SL, Francis CW, Taubman MB, Phipps RP (2009) The platelet as an immune cell-CD40 ligand and transfusion immunomodulation. Immunol Res 45: 251-260.
• Boehlen F, Clemetson KJ (2001) Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice? Transfus Med 11: 403-417.
• Boilard E, Nigrovic PA, Larabee K, Watts GF, Coblyn JS, Weinblatt ME, Massarotti EM, Remold-O’Donnell E, Farndale RW, Ware J, Lee DM (2010) Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 327: 580-583.
• Boncler M, Watała C (2000) Role of FcaRIIA receptor in platelet activation and its significance in heparin-induced thrombocytopenia. Acta Haematol Pol 31: 241-248.
• Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z, Kelly MM, Patel KD, Chakrabarti S, McAvoy E, Sinclair GD, Keys EM, Allen-Vercoe E, Devinney R, Doig CJ, Green FH, Kubes P (2007) Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 13: 463-469.
• Elzey BD, Grant JF, Sinn HW, Nieswandt B, Waldschmidt TJ, Ratliff TL (2005) Cooperation between platelet-derived CD 154 and CD4+ T cells for enhanced germinal center formation. J Leukoc Biol 78: 80-84.
• Elzey BD, Ratliff TL, Sowa JM, Crist SA (2011) Platelet CD40L at the interface of adaptive immunity. Thromb Res 127: 180-183.
• Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees JR, Lentz SR, Stein CS, Nieswandt B, Wang Y, Davidson BL, Ratliff TL (2003) Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity 19: 9-19.
• Haselmayer P, Grosse-Hovest L, von Landenberg P, Schild H, Radsak MP (2007) TREM-1 ligand expression on platelets enhances neutrophil activation. Blood 110: 1029-1035.
• Huang ZY, Chien P, Indik ZK, Schreiber AD (2011) Human platelet FcγRIIA and phagocytes in immune-complex clearance. Mol Immunol 48: 691-696.
• Krijgsveld J, Zaat SA, Meeldijk J, van Veelen PA, Fang G, Poolman B, Brandt E, Ehlert JE, Kuijpers AJ, Engbers GH, Feijen J, Dankert J (2000) Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines. J Biol Chem 275: 20374-20381.
• Li N (2008) Platelet- lymphocyte cross-talk. J Leukoc Biol 83: 1069-1078.
• Nurden AT (2011) Platelets, inflammation and tissue regeneration. Thromb Haemost 105: S13-S33.
• Pijanowski Ł, Kołaczkowska E, Chadzińska M (2011) Neutrophil extracellur traps (NET)- New neutrophil strategy to combat pathogens. Post Biol Kom 38: 653-672.
• Semple JW, Freedman J (2010) Platelets and innate immunity.Cell Mol Life Sci 67: 499-511.
• Semple JW, Italiano JE, Freedman J (2011) Platelets and the immune continuum. Nat Rev Immunol 11: 264-274.
• Smorąg I, Baj Z (2008) Nonhemostatic role of platelets. Diagnostyka Laboratoryjna 44: 241-248.
• Stosik M, Deptuła W (1998) Selected functions of platelets. Med Wet 54: 462-465.
• Tilley SL, Coffman TM, Koller BH (2001) Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 108: 15-23.
• Vieira-de-Abreu A, Campbell RA, Weyrich AS, Zimmerman A (2012) Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. Semin Immunopathol 34: 5-30
• Ważna E (2006) Platelet-mediated regulation of immunity. Post Hig Med Dosw 60: 265-277.
• Weyrich AS, Lindemann S, Zimmerman GA (2003) The evolving role of platelets in inflammation. J Thromb Haemost 1: 1897-1905.
• Weyrich AS, McIntyre TM, McEver RP, Prescott SM, Zimmerman GA (1995) Monocyte tethering by P-selectin regulates monocytes chemotactic protein-1 and tumor necrosis factor- alpha secretion. Signal integration and NF- kappa B translocation. J Clin Invest 95: 2297-2303.
• Weyrich AS, Zimmerman GA (2004) Platelets: signaling cells in the immune continuum. Trends Immunol 25: 489-495.
• White JG (2006) Why human platelets fail to kill bacteria. Platelets 17: 191-200.
• Yong EC, Chi EY, Fritsche TR, Henderson WR Jr (1991) Human platelet- mediated cytotoxicity against Toxoplasmagondii: role of tromboxane. J Exp Med 173: 65-78.