Polyethylene glycol - modified nanocarrier encapsulation of Diminazene aceturate improved haematobio- chemical recovery in Trypanosoma brucei brucei infected rats

• Autorzy: Shittu O.K. , Lawal B. , Ojo A.J. , Yisa A.S.
• Języki publikacji: EN

Abstrakty

EN

The enhanced safe drug delivery properties of polyethylene glycol (PEG) – modified Diaminazene aceturate nanocomposite against Trypanosoma brucei infected rats were evaluated. The drug conjugation was carried out by adding gold nanoparticle to PEG and diminazene aceturate. A group of infected rats were treated with free diaminazene aceturate, while other groups were treated with conjugated drug at different drug release time interval. Results revealed complete parasite clearance on day 4 and 6 post infection for rats treated with free drug and nano-formulated drug at 3–15 minutes release time. Rats treated with three minutes drug release shows satisfactory serum and liver enzyme activities as well as high RBC counts when compared (p < 0.05) with infected untreated and infected treated with free drug. The hematatological indices of non treated rats were lower than those treated with free and nano-formulated drug. Nanoencapsulation of diminazene aceturate therefore improved drug delivery and reduced toxicity in the treatment of African trypamosomiasis

• Wydawca: -
• Czasopismo: Polish Journal of Natural Sciences
• Rocznik: 2019
• Tom: 34
• Numer: 2
• Opis fizyczny: p.317-332,fig.,ref.

Twórcy

autor

Shittu O.K.

• Nano Research Unit, Department of Biochemistry, Federal University of Technology in Minna, Minna, Nigeria

autor

Lawal B.

• Nano Research Unit, Department of Biochemistry, Federal University of Technology in Minna, Minna, Nigeria

autor

Ojo A.J.

• Nano Research Unit, Department of Biochemistry, Federal University of Technology in Minna, Minna, Nigeria

autor

Yisa A.S.

• Nano Research Unit, Department of Biochemistry, Federal University of Technology in Minna, Minna, Nigeria

Bibliografia

• ADEYEMI O.S., FANIYAN T.O., ADEYEMI O.S. 2014. Antioxidant status of rats administered silver nanoparticles orally. J. Taibah Univ. Med. Sci., 9: 182–186.
• BASHIR L., SHITTU O.K., SANI S., BUSARI M.B., ADENNIYI K.A. 2015. African natural products with potential antitrypanosomaproperties: A review. Int. J. Biochem. Res. Rev., 7(2): 45–79.
• BEERS R.F. JR., SIZER I.W. 1952. Aspectrophotometrical method for measuring the breakdown of hydrogen peroxide by catalase. J. Biol. Chem., 195(1): 133–195.
• BERINYUY E.B., LAWAL B., OLALEKAN A.A., OLALEKAN A.A., YUSUF A.A., SAKPE S., OSSAI P.C. 2015. Hematologicalstatus and organs/body-weight parameters in Wister rats during chronic administration of Cassia occidentalis. Inter. Blood Res. Rev., 4(3): 1–7.
• BHARALI D.J., KHALIL M., GURBUZ M., SIMONE T.M., MOUSA S.A. 2009. Nanoparticles and cancer therapy: A concise review with emphasis on dendrimers. Inter. J. Nanomed., 4: 1–7.CCAC guidelines on: animal use protocol review. Ottawa, Canadian Council on Animal Care. 1997, http://www.ccac.ca/Documents/ Standards/Guidelines/Protocol_Review.pdf, Access: 1.12.2016.
• DACIE J.V., LEWIS S.M. 1991. Practical hematology, 7th edition. Churchill Livingston, Edinburgh, pp. 1–22.
• EKANEM J.T., YUSUF O.K. 2015. Activities of alkaline phosphatase, glutamate oxaloacetate trans-aminase and glutamate pyruvate transaminase in liver and serum of Trypanosoma brucei – infected rats treated with honey. Biokemistri, 17: 185–191.
• EKANEM J.T., YUSUF O.K. 2008. Some biochemical and haematological effects of black seed (Nigel-la sativa) oil on T. brucei – infected rats. Afr. J. Biomed. Res., 4(11): 79–85.
• GILJOHANN D.A., SEFEROS D.S., DANIEL W.L., MASSICH M.D., PATEL P.C., MIRKIN C.A. 2010. Gold nanoparticles for biology and medicine. Angewandte Chemie International Edition, 49: 3280–3294.
• HUANG J., LI Q., SUN D., LU Y., SU Y., YANG X., WANG H. 2007. Biosynthesis of silver and gold nanoparticles by novel sundried Cinnamomum camphora leaf. Nanotechnology, 18(10): 10 5104–10 5115.
• JAE Y.S., BEOM S.K. 2010. Biological synthesis of gold nanoparticles using Magnolia kobus and Diopyros kaki leaf extracts. Process Biochem., 44: 1133–1138.
• KENNEDY G.E.P. 2004. Human African trypanosomiasis of the CNS: current issues and challen-ges. J. Clin. Invest., 113: 496–504.
• LAWAL B., SHITTU O.K., INJE O.F., BERINYUY E.B., MUHAMMED H. 2016. African natural products with potential antioxidants and hepatoprotectives properities. A review. Clin. Phytosci., 2(23): 1–66.
• LAWAL B., SHITTU O.K., INJE O.F., MOHAMMEDH., UMAR S.I., HARUNA G.M. 2016. Antimicrobial evaluation, acute and sub-acute toxicity studies ofAllium sativum. J. Acute Dis., 5(4): 296–301.
• LAWAL B., SHITTU O.K., BLESSINGUCHENNA A.B., HARUNAG.M., ABUBAKARA. N., BERINYUY E.B. 2015. Alteration in biochemical indices following chronic administration of methanolic extract of Nigeria bee propolis in wister rats. Asian Pac. J. Trop. Dis., 5(8): 654–657.
• LEE M., KIM S.W. 2005. Polyethylene glycol-conjugated copolymers for plasmid DNA delivery. Pharma. Res., 22: 1–10.
• LEGROS D., OLLIVIER G., GASTELLU-ETCHEGORRY M., PAQUET C., BURRI C., JANNIN J., BUSCHER P.2002. Treatment of human African trypanosomiasis – present situation and needs for research and development. Lancet, 2: 437–440.
• LIANG X.J., CHEN C., ZHAO Y., JIA L., WANG P.C. 2008. Biopharmaceutics and therapeutic poten-tial of engineered nanomaterials. Curr. Drug Metabol., 9: 697–709.
• MAHAJAN B.K. 1997. Significance of difference in means. In: Methods in biostatistics for medical and research workers. 6th edition, JAYEET Brothers Medical Publishers, New Delhi, pp.130–155.
• MANN M., OLUWASEYI R.I., ABDULFATAI T.A., CHIDIEBERE U., EKPENYONG E.U., ISAAC I.O., MOHAMMED S.S., DAUDA R.I., YUSUF A.Y., KABIR A.Y., OGBADOYI E.O. 2011. In vivo antitry-panosomal effects of some ethnomedicinal plants from Nupeland of North Central Nigeria. J. Tradit. Complement. Altern. Med., 8(1): 15–21.
• MOCAN T., CLICHICI S., AGOŞTON-COLDEA L., MOCAN L., ŞIMON Ş., ILIE I.R. 2010. Implications of oxidative stress mechanisms in toxicity of nanoparticles (review). Acta Physiol., 97: 247–255.
• OGUNSANMI A.O., TAIWO V.O. 2007. Pathobiochemical mechanism involved in the control of the disease caused by Trypanosoma congolense in African grey duiker (Sylvicapra grimmia). Vet. Parasitol., 96: 51–63
• PARVEEN S., MISRA R., SAHOO S.K. 2012. Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging. Nanomedicine. Nanotech. Biol. Med., 8: 147–166.
• REITMAN S., FRANKEL S. 1957. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol., 28: 56–63.
• SHANKAR S.S., RAI A., AHMAD A., SASTRY M. 2004. Rapid synthesis of Au, Ag, and bimetallic Au core Ag shell nanoparticles using neem (Azadirzchta indica) leaf broth. J. Coll. Inter. Sci., 275: 496–502.
• SHITTU O.K., LAWAL B., OLUYOMI O.I. 2014. Effects of methanol extract of Musca domestica larvae on antioxidants enzymes in T. brucei infected rats. Nig. J. Biochem. Mol. Biol., 29(2): 1–10.
• SHITTU O.K., MUSA F., GBADAMOSI D.F. 2013.Trypanocidal activity and heamatological changes in T. brucei infected rats treated with methanolic leaf extract of Thymus vulgaris. Inter. J. Appl. Biol. Res., 5(1 and 2): 109–114.
• SHITTU O.K., STEPHEN D.I. 2016a. Cytotoxicity property of biologically synthesized Gold Nanopar-ticles from aqueous leaf extract of Calotropis procera (Apple of Sodom) on MCF-7 Cell Line. Brit. J. Med. Med. Res., 15(12): 1–8.
• SHITTU O.K., STEPHEN D.I. 2016b. In vitro membranous activity of biosynthesized Gold Nanopar-ticle from aqueous leave Extract ofNelsonia canescens. Europ. J. Med. Plan., 15(2): 1–8.
• SHITTU O.K., AARON S.Y., OLADUNTOYE M.D. LAWAL, B. 2018. Diminazene aceturate modified nanocomposite for improved efficacy in acute trypanosome infection. J. Acute Dis., 7(1): 36–42.
• SHITTU O.K., LAWAL B., ADENIYI A.K., KILANI L.T., SAKA R.B. 2017. Effect of Methanol extract of Musca domestica larva on some enzymes and haematological parameters in Trypanosoma brucei brucei – infected rats. Nig. J. Basic Appl. Sci., 25(2): 66–74.
• TIETZ N.W. 1995. Clinical guide to laboratory tests. 3rd ed. Philadelphia, PA, WB Saunders Com-pany, pp. 286–288.
• TING G., CHANG C.H., WANG H.E. 2009.Cancer nanotargeted radiopharmaceuticals for tumor imaging and therapy. Anticancer Res., 29: 4107–4118.
• UMAR I.A., OGENYI E., OKODASO D., KIMENG E., STANCHEVA G.I., OMAGE J.J., ISAH S., IBRAHIM M.A. 2007. Amelioration of anaemia and organ damage by combined intraperitoneal administra-tion of vitamins A and C to Trypanosoma brucei brucei – infected rats. Afr. J. Biotechnol., 6: 2083–2086.
• UMESH K.P., BIRENDRA K.B., PADMALOCHAN N. 2011. Green synthesis and characterization of gold nanoparticles using onion (Allium cepa) extract. World J. Nanosci. Engineer., 1: 93–98.
• YUSUF A.B., UMAR I.A, NOK A.J. 2012. Effects of methanol extract of Vernonia amygdalina leaf on survival and some biochemical parameters in acute Trypanosoma brucei brucei infection. Afric. J. Biochem. Res., 6(12): 150–158.
• YUSUF A.A., LAWAL B., ABUBAKAR A.N., BERINYUY E.B., OMONIJE Y.O., UMAR S.I., SHEBE M.N., ALHAJI Y.M. 2018a. In-vitro antioxidants, antimicrobial and toxicological evaluation of Nige-rian Zingiber officinale. Clin. Phytosci., 4(12): 1–8.
• YUSUF A.A., LAWAL B., YUSUF M.A., OMONIJE Y.O., ADEJOKE A.A., RAJI F.H., WENAWO D.L. 2018b. Free radical scavenging, antimicrobial activities and effect of sub-acute exposure to Nigerian Xylopia Aethiopica seed extract on liver and kidney functional indices of Albino Rat. Iran J. Toxicol., 12(3): 51–58