PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2014 | 74 | 3 |

Tytuł artykułu

Regulation of hippocampal theta rhythm by the ventral tegmental area in freely moving rats

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Ventral tegmental area (VTA) is thought to be an important component in the mesocorticolimbic system involved in the regulation of theta rhythm in the hippocampus. In this study we investigated the effect of pharmacological inactivation of the VTA on theta rhythm parameters in fear conditioned rats. Animals were implanted with bilateral recording electrodes into the dorsal hippocampus and bilateral injection cannula into the VTA. Hippocampal LFP was recorded throughout the experiment, in pre- and post-injection condition during freezing behavior and active locomotion (avoidance). We found that intra-VTA injection of procaine temporary suppressed avoidance response and decreased the power of hippocampal theta rhythm during freezing in comparison to control (water). Our results indicate that inactivation of neuronal activity in the VTA reduces hippocampal theta rhythm as well as avoidance response in fear conditioned animal. Supported by MNiSW Grant IP2011 034371.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

74

Numer

3

Opis fizyczny

p.338

Twórcy

  • Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland
  • Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland
  • Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland
  • Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland

Bibliografia

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-98e9d27b-cb77-4871-827c-0f0807e519ce
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.