Chorobotwórczość Clostridium difficile u człowieka i zwierząt w ocenie ewentualnych wzajemnych powiązań

• Autorzy: Truszczynski M. , Pejsak Z.

Warianty tytułu

EN

Pathogenicity of Clostridium difficile in humans and animals in the assessment of eventual connections

• Języki publikacji: PL

Abstrakty

EN

The paper reviews literature concerning Clostridium (C.) difficile. The properties and its role in the etiology and pathogenesis of the disease in humans and animals including food animals, companion animals and laboratory animals is presented. The importance of toxin A and toxin B in the pathogenicity of C. difficile is stressed. The major risk factor in provoking diarrhea is the use of antibiotics, particularly in hospitalized patients with increasing age, in the presence in the intestinal flora of C. difficile. Besides antibiotics, other conditions that may affect the intestinal flora are also favoring the development of the disease caused by C. difficile. The disease likewise occurs outside the hospital. As an etiological agent with a pathogenesis similar to that mentioned in humans, during the last years C. difficile is increasingly recognized in animals, as well. It is the most important cause of neonatal diarrhea in swine in some regions of the world. C. difficile infection in foals and mature horses may vary from a mild disease with diarrhea to a life-threatening disease. C. difficile has proved to be pathogenic for dogs and cats. According to the cited literature, while the transmission of C. difficile from animals to humans does take place, zoonotic activity of strains originating from animals has not been demonstrated.

Słowa kluczowe

PL

mikrobiologia; bakterie; Clostridium difficile; wystepowanie; chorobotworczosc; biegunki poantybiotykowe; patogeneza; objawy chorobowe; epidemiologia; czlowiek; zwierzeta; nosicielstwo

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2012
• Tom: 68
• Numer: 08
• Opis fizyczny: s.451-455,bibliogr.

Twórcy

autor

Truszczynski M.

• Zakład Chorób Świń, Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy, Al.Partyzantów 57, 24-100 Puławy

autor

Pejsak Z.

Bibliografia

• 1.Al Saif N., Brazier J. S.: The distribution of Clostridium difficile in the environment of South Wales. J. Med. Microbiol. 1996, 45, 133-137.
• 2.Anderson M. A., Songer J. G.: Evaluation of two enzyme immunoassays for detection of Clostridium difficile toxins A and B in swine. Vet. Microbiol. 2008, 128, 204-206.
• 3.Arroyo L. G., Staempfli H., Weese J. S.: Molecular analysis of Clostridium difficile isolates recovered from horses with diarrhea. Vet. Microbiol. 2007, 120, 179-183.
• 4.Arroyo L. G., Stampili H. R., Weese J. S.: Potential role of Clostridium difficile as a cause of duodenitis-proximal jejunitis in horses. J. Med. Microbiol. 2006, 55,605-608.
• 5.Avbersek J., Janezic A., Pate M., Rupnik M., Zidaric V., Logar K., Vengust M., Zemljic M., Pirs T., Ocepek M.: Diversity of Clostridium difficile in pigs and other animals in Slovenia. Anaerobe 2009, 15, 252-255.
• 6.Baverud V.: Clostridium difficile infections in animals with special reference to the horse. A review. Vet. Q 2002, 24, 203-219.
• 7.Baverud V., Gustafsson A., Franklin A., Aspan A., Gunnarsson A.: Clostridium difficile: prevalence in horses and environment, and antimicrobial susceptibility. Equine Vet. J. 2003, 35, 465-471.
• 8.Baverud V., Gustafsson A., Franklin A., Lindholm A., Gunnarsson A.: Clostridium difficile associated with acute colitis in mature horses treated with antibiotics. Equine Vet. J. 1997, 29, 279-284.
• 9.Berg R. J. van den, Claus E. C., Oyib D. H., Klaassen C. H., Dijkshoorn L., Brazier J. S., Kuijper E. J.: Characterization of toxin a-negative toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping. J. Clin. Microbiol. 2004, 42, 1035-1041.
• 10.Borriello S. P.: Pathogenesis of Clostridium difficile infection. J. Antimicrob. Chemother. 1998, 41 (Suppl. C), 13-19.
• 11.Clooten J., Kurth S., Arroyo L. Weese J. S.: Prevalence and risk factors for Clostridium difficile colonization in dogs and cats hospitalized in an intensive care unit. Vet. Microbiol. 2008, 129, 209-214.
• 12.Debast S. B., van Leengoed L. A., Goorhuis A., Harmanus C., Kuijper E. J. Bergwerff A. A.: Clostridium difficile PCR ribotype 078 toxinotype V found in diarrhoeal pigs identical to isolates from affected humans. Environ. Microbiol. 2009, 11, 505-511.
• 13.Geric B., Carman R. J., Rupnik M., Genheimer C. W., Sambol S. P., Lyerly D. M., Gording D. N., Johnson S.: Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters. J. Infect. Dis. 2006, 193, 1143-1151.
• 14.Hammitt M. C., Bueschel D. M., Keel M. K., Glock R. D., Cuneo P., DeYoung D. W., Reggiardo C., Trinh H. T., Songer J. G.: A possibile role for Clostridium difficile in the etiology of calf enteritis. Vet. Microbiol. 2008, 127, 343-352.
• 15.Hensgens M. P., Goorhuis A., Notermans D. W., van Benthem B. H., Kuijper E. J.: Decrease of hypervirulent Clostridium difficile PCR ribotype 027 in the Netherlands. Euro Surveill. 2009, 14, 19402.
• 16.Hirsh D. C., MacLachlan N. J., Walker R. L.: Clostridium, [w:] Veterinary Microbiology. 2nd ed., Blackwell Publishing Ames, Iowa, USA 2004, 202-208.
• 17.Huhulescu S., Kiss R., Brettlecker M., Cerny R. J., Hess C., Wewalka G., Allerberger F.: Etiology of acute gastroenteritis in three sentinel general practices Austria 2007. Infection 2009, 37, 103-108.
• 18.Indra A., Lassnig H., Baliko N., Much P., Fiedler A., Huhulescu S., Allerberger F.: Clostridium difficile: a new zoonotic agent? Wien. Klin. Wochenschr. 2009, 121, 91-95.
• 19.Keel K., Brazier J. S., Post K. W., Weese S., Songer J. G.: Prevalence of PCR ribotypes among Clostridium difficile isolates from pigs, calves, and other species. J. Clin. Microbiol. 2007, 45, 1963-1964.
• 20.Keel M. K., Songer J. G.: The comparative pathology of Clostridium difficile-associated disease. Vet. Pathol. 2006, 43, 225-240.
• 21.Keel M. K., Songer J. G.: The distribution and density of Clostridium difficile toxine receptors on the intestinal mucosa of neonatal pigs. Vet. Pathol. 2007, 44, 814-822.
• 22.Keessen E. C., Gaastra W., Lipman L. J. A.: Clostridium difficile infection in humans and animals, differences and similarities. Vet. Microbiol. 2011, 153, 205-217.
• 23.Keessen E. C., Leengoed L. A., Bakker D., van den Brink K. M., Kuijper E. J., Lipman L. J.: Prevalence of Clostridium difficile in swine thought to have Clostridium difficile infections (CDI) in eleven swine operations in the Netherland. Tijdschr. Diergeneeskd. 2010, 135, 134-137.
• 24.Kelly C. P., Pothoulakis C., Lament J. T.: Clostridium difficile colitis. N. Engel. J. Med. 1994, 330, 257-262.
• 25.Leengoed L. van, Debast S. B., Bergwerff A. A., Kuiper E. J.: Neonatal diarrhea in piglets caused by Clostridium difficile, [w:] Proceedings of the 20th IPVF Congress, Durban South Africa, June 2008, 134.
• 26.Magdesian K. G., Dujowich M., Madigan J. E., Hansen L. M., Hirsh D. C., Jang S. S.: Molecular characterization of Clostridium difficile isolates from horses in a intensiva care unit and association of disease severity with strain type. J. Am. Vet. Med. Assoc. 2006, 228, 751-755.
• 27.Magdesian K. G., Hirsh D. C., Jang S. S., Hansen L. M., Madigan J. E.: Characterization of Clostridium difficile isolates from foals with diarrhea: 28 cases (1993-1997). J. Am. Vet. Med. Assos. 2002, 220, 67-73.
• 28.Marks S. L., Kather E. J., Kass P. H., Melli A. C.: Genotypic and phenotypic characterization of Clostridium perfringens and Clostridium difficile in diarrheic and healthy dogs. Vet. Intern. Med. 2002, 16, 533-540.
• 29.Norman K. N., Harley R. B., Scott H. M., Hume M. E., Andrews K., Brawley A. D.: Varied prevalence of Clostridium difficile in an integrated swine operation. Anaerobe 2009, 15, 256-260.
• 30.Poutanen S. M., Simor A. E.: Clostridium difficile-associated diarrhea in adults. CMAJ 2004, 51-58.
• 31.Rehg J. E., Lu Y. S.: Clostridium difficile typhlitis in hamsters not associated with antibiotic therapy. J. Am. Vet. Med. Assoc. 1982, 181, 1422-1423.
• 32.Rodriguez-Palacios A., Stämpfli H. R., Duffield T., Peregrine A. S., Trotz-Williams L. A., Arroyo L. G., Brazier J. S., Weese J. S.: Clostridium difficile PCR ribotypes in calves, Canada. Emerg. Infect. Dis. 2006, 12, 1730-1736.
• 33.Rodriguez-Palacios A., Stämpfli H. R., Stalker M., Duffield T., Weese J. S.: Natural and experimental infection of neonatal calves with Clostridium difficile. Vet. Microbiol. 2007, 124, 166-172.
• 34.Ruby R., Magdesian K. G., Kass P. H.: Comparison of clinical microbiologic, and clinicopathologic findings in horses positive and negative for Clostridium difficile infection. J. Am. Vet. Med. Assoc. 2009, 234, 777-784.
• 35.Rupnik M.: Is Clostridium difficile-associated infection a potentially zoonotic and foodborne disease? Clin. Microbiol. Infect. 2007, 13, 457-459.
• 36.Songer J. G.: The emergence of Clostridium difficile as a pathogen of food animals. Anim. Health Res. Rev. 2004, 5, 321-326.
• 37.Songer J. G., Anderson M. A.: Clostridium difficile: an important pathogen of food animals. Anaerobe 2006, 12, 1-4.
• 38.Songer J. G., Jones R., Anderson M. A., Barbara A. J., Post K. W., Trinh H. T.: Prevention of porcine Clostridium difficile-associated disease by competitive exclusion with nontoxigenic organisms. Vet. Microbiol. 2007, 124, 358-361.
• 39.Songer J. G., Post K. W., Larson D. J., Jost B. H., Glock R. D.: Infection of neonatal swine with Clostridium difficile. Swine Health Prod. 2000, 8, 185-189.
• 40.Squire M. M., Thean S., Chang B. J., Riley T. V.: A novel molecular type of Clostridium difficile in neonatal pigs in Australia, [w:] Proc. of the Third International Clostridium difficile Symposium, Bled, Slovenia, September 2010, 31.
• 41.Steele J., Feng H., Parry N., Tzipori S.: Piglet models of acute or chronic Clostridium difficile illness. J. Infect. Dis. 2010, 201, 428-434.
• 42.Struble A. L., Tang Y. J., Kass P. H., Gumerlock P. H., Madewell B. R., Silva Jr. J.: Fecal shedding of Clostridium difficile in dogs: a period prevalence survey in a veterinary medical teaching hospital. J. Vet. Diagn. Incest. 1994, 6, 342-347.
• 43.Tonna I., Welsby P. D.: Pathogenesis and treatment of Clostridium difficile infection. Postgrad. J. Med. 2005, 81, 367-369.
• 44.Weese J. S., Finley R., Reid-Smith R. R., Janecko N., Rousseau J.: Evaluation of Clostridium difficile in dogs and the household environment. Epidemiol. Infect. 2010, 138, 1100-1104.
• 45.Weese J. S., Staempfli H. R., Prescott J. F.: A prospective study of the roles of Clostridium difficile and enterotoxigenic Clostridium perfringens in equine diarrhoea. Equine Vet. 2001, 33, 403-409.
• 46.Weese J. S., Staempfli H. R., Prescott J. F., Kruth S. A., Greenwood S. J., Weese H. E.: The roles of Clostridium difficile and enterotoxigenic Clostridium perfringens in diarrhea in dogs. J. Vet. Intern. Med. 2001, 15, 374-378.
• 47.Yaeger M. J., Kinyon J. M., Songer J. G.: A prospective case control study evaluating the association between Clostridium difficile toxins in the colon of neonatal swine and gross and microscopic lesions. J. Vet. Diagn. Incest. 2007, 19, 52-59.
• 48.Zidaric V., Zemljic M., Janezic S., Kocuvan A., Rupnik M.: High diversity of Clostridium difficile genotypem isolated from a single poultry farm producing replacement laying hens. Anaerobe 2008, 14, 325-327.