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1989 | 40 | 5-6 |
Tytuł artykułu

Free amino acids in basal and vagally stimulated gastric secretion

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Komorowska, M., Szafran, H., Szafran, Z. and Popiela T.: Free amino acids in basal and vagally stimulated gastric secretion. Acta physiol, pol., 1989,40(5-6): 496-503. The concentrations of the individual free amino acids were determined in one hour fraction of basal secretion and peak hydrogen ion secretion following stimulation with 2-deoxy-D-glucose (2-DG) (group I) or insulin (group II). Group I consisted of 9 patients with duodenal ulcer having hypersecretion of gastric acid as determined by histamine test; 7 patients with duodenal ulcer who underwent truncal vagotomy and had insulin test performed two weeks after the operation formed group II. The total concentration of free amino acids was similar in basal and in stimulated gastric juice in both groups. Also the concentrations of the individual amino acids did not change significantly after stimulation. There was, however, a significant increase following stimulation in the output of amino acids both in group I and in group II. This increase was parallel to that in the volume of gastric juice, which suggests that a definite amount of free amino acids is always present in the gastric juice, and that the secretion of these acids is not under vagal control.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
40
Numer
5-6
Opis fizyczny
p.496-503,ref.
Twórcy
  • Department of Clinical Biochemistry, Institute of Pediatrics and 1-st Department of Surgery, Nicolas Copernicus School of Medicine, Krakow, Poland
autor
  • Department of Clinical Biochemistry, Institute of Pediatrics and 1-st Department of Surgery, Nicolas Copernicus School of Medicine, Krakow, Poland
autor
  • Department of Clinical Biochemistry, Institute of Pediatrics and 1-st Department of Surgery, Nicolas Copernicus School of Medicine, Krakow, Poland
autor
  • Department of Clinical Biochemistry, Institute of Pediatrics and 1-st Department of Surgery, Nicolas Copernicus School of Medicine, Krakow, Poland
Bibliografia
  • 1. Alijew, A. I. (1978) Wlijanie selektiwnoj wagotomii na bielkowyj i aminokislyj sostaw zeludnocznowo soka. Fizjologiczeskij Zurnal SSSR. 64. 766-769.
  • 2. Bouda, J. (1962) Einige neue Ergebnisse in der Biochemie der Eiweisstoffe des Magensekretes. Z. inn. Med. 17. 1029-1030.
  • 3. Dunzendorfer, U. (1976) Klinische Bedeutung der Aminosauren im Magensaft. Munch, med. Wschr. 118. 1495-1496.
  • 4. Dunzendorfer, U. (1977) Der Einfluss von Pentagastrin auf den Gehalt an freien Aminosauren im Magensaft. J. Clin. Chem. Clin. Biochem. 15. 27-29.
  • 5. Heathcote, J. G., Washington, R. J. (1965) Amino-acids and peptides in human gastric juice with particular reference to pernicious anaemia. A review. Nature 207. 941-944.
  • 6. Isenberg, J. I., Maxwell, V. (1978) Intravenous infusion of amino acids stimulates gastric acid secretion in man. N. Engl J. Med. 298. 27-29.
  • 7. Kauffman, G. L., Grossman, M. I. (1982) Components of acidification of an amino acid solution bathing oxyntic mucosa. Am. J. Physiol. 243. G336-G340.
  • 8. Kaye, A. W. (1953) Effect of large doses of histamine on gastric secretion of HCI. Brit. Med. J. 2. 77-79.
  • 9. Komorowska, M. et al. (1981) Free amino acids of human gastric juice. Acta Physiol. Pol. 32. 559-567.
  • 10. Konturek, S. J. et al. (1976) Comparison of amino acids bathing the oxyntic gland area in the stimulation of gastric secretion. Gastroenterology 70. 66-69.
  • 11. Popiela, T. et al. (1978) Use of 2.deoxy-D-glucose as a stimulant in gastric secretion test performed in duodenal ulcer patients (in Polish). Pol. Tyg. Lek. 33. 577-580.
  • 12. Popiela, T. et al. (1972) Evaluation of the completeness of vagotomy in patients with duodenal ulcer basing on insulin test and the test using 2-deoxy-D-glucose (in Polish). Przeg. Lek. 29. 748-755.
  • 13. Saitoh, Y. et al. (1979) Effect of eight amino acids on the exocrine and endocrine pancreatic function. Tohoku J. Exp. Med. 129. 257-272.
  • 14. Spackman, D. H. (1962) Instruction manual AJM-2. Spinco Division. Beckman Instruments Inc., Palo Alto, California.
  • 15. Stubbs, R. S. (1985) Role of cholecystokinin in pancreatic exocrine response to intraluminal amino acids and fat. Am. J. Physiol. 248. 347-352.
  • 16. Taylor, J. L. et al. (1982) Effect of individual L-amino acids an gastric acid secretion and serum gastrin and pancreatic polypeptide release in humans. Gastroenterology 82. 273-278.
  • 17. Trompeter, G. et al. (1977) Lipase and pepsin activity in gastric juice collected during infusion of graded doses of pentagastrin in patients with duodenal ulcer. Przeg. Lek. 34. 481-487.
  • 18. Warren, S. et al. (1951) Paper partition chromatography of amino acids of gastric juice of patients with gastric lesions. J. Nat. Cane. Inst. 12. 677-689.
Typ dokumentu
Bibliografia
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