Effects of blood lead and cadmium levels on the functioning of children with behaviour disorders in the family environment

• Autorzy: Szkup-Jablonska M. , Karakiewicz B. , Grochans E. , Jurczak A. , Nowak-Staz G. , Rotter I. , Prokopowicz A.
• Języki publikacji: EN

Abstrakty

EN

Introduction and objective: The developing brain of a child is extremely prone to damage resulting from exposure to harmful environmental factors, e.g. heavy metals. Intoxication of children’s organisms with lead and cadmium affects their intellectual development. Even a relatively small amount of this metal in children’s blood can lead to developmental dysfunctions. The aim of this study was to analyse the correlation between blood lead and cadmium levels in children with behaviour disorders and their functioning in the home. Material and methods: This survey-based study was conducted among 78 families with children diagnosed as having behaviour disorders. It was performed using the ADHD-Rating Scale-IV. To determine lead and cadmium levels the laboratory procedure was based on Stoppler and Brandt’s method. Results: The mean blood lead level was 19.71 μg/l and the mean blood cadmium level was 0.215μg/l. Higher blood lead levels in children correlates positively with incidences of hyperactive and impulsive behaviour in the home, as assessed by parents (p=0.048). Statistically significant effects of cadmium on children’s behaviour were not noticed. Conclusions: The effect of lead on the developing organism of a child has such behavioural consequences as attention disorders, hyperactivity and impulsive behaviour which, in turn, may interfere with children’s functioning in the home. A negative effect of cadmium on the functioning of children with behaviour disorders in the home was not proved.

• Wydawca: -
• Czasopismo: Annals of Agricultural and Environmental Medicine
• Rocznik: 2012
• Tom: 19
• Numer: 2
• Opis fizyczny: p241.246,fig.,ref.

Twórcy

autor

Szkup-Jablonska M.

• Laboratory of Propaedeutics in Nursing, Pomeranian Medical University, Szczecin, Poland

autor

Karakiewicz B.

• Public Health Department, Pomeranian Medical University, Szczecin, Poland

autor

Grochans E.

• Laboratory of Propaedeutics in Nursing, Pomeranian Medical University, Szczecin, Poland

autor

Jurczak A.

• Laboratory of Propaedeutics in Nursing, Pomeranian Medical University, Szczecin, Poland

autor

Nowak-Staz G.

• Department of Developmental Age, Natural and Medical University, Kielce, Poland

autor

Rotter I.

• Public Health Department, Pomeranian Medical University, Szczecin, Poland

autor

Prokopowicz A.

• Department of Chemical Damage, Institute of Industrial Medicine and Community Health, Sosnowiec, Poland

Bibliografia

• 1. Stein J, Schettler T, Hallinga D, et al. In harm’s way: Toxic threats to child development. J Dev Behav Pediatics. 2002: 2313-22.
• 2. Cantonwine D, Hu H, Sánchez BN, Lamadrid-Figueroa H, Smith D, Ettinger AS, Mercado-García A, Hernández-Avila M, Wright RO,Téllez-Rojo MM. Critical windows of fetal lead exposure: adverseimpacts on length of gestation and risk of premature delivery. J OccupEnviron Med. 2010;52(11): 1106-11.
• 3. Toxicological profile for lead. U.S. Department of Health and Human Services. Public Health Service. Agency for Toxic Substances andDisease Registry, 2007
• 4. CDC. Third national report on human exposure to environmental chemicals. Centers for Disease Control and Prevention. Atlanta, GA:U.S. Department of Health and Human Services. 2005
• 5. Nigg JT. ADHD, lead exposure and prevention: how much lead or how much evidence is needed? Expert Review of Neurotherapeutics 2008;8(4): 519-521.
• 6. Counter SA, Buchanan LH, Ortega F. Neurocognitive impairment in lead-exposed children of Andean lead-glazing workers. J OccupEnviron Med.. 2005; 47(3): 306-12
• 7. Tellez-Plaza M, Navas-Acien A, Crainiceanu CM, et al. Cadmium exposure and hypertension in the 1999-2004 National Health andNutrition Examination Survey (NHANES). Environmental HealthPerspectives 2008; 116(1): 51-56.
• 8. Hu H. Exposure to metals. Prim Care. 2000; 27(4): 983-996.
• 9. ATSDR. Toxicological Profile for Cadmium. Atlanta, GA: Agency for Toxic Substances and Disease Registry 1999.
• 10. Baranski B. Behavioral alterations in offspring of female rats repeatedly exposed to cadmium oxide by inhalation. Toxicol Lettn. 1984; 22: 53-61.
• 11. Baranski B. Effect of exposure of pregnant rats to cadmium on prenatal and postnatal development of the young. J Hyg Epidemiol MicrobiolImmunol. 1985; 29: 253-262.
• 12. Gupta A, Gupta A, Chandra SV. Gestational cadmium exposure and brain development: a biochemical study. Ind Health. 1991; 29(2): 65-71
• 13. Singhal RL, Merali Z, Hrdina PD. Aspects of the biochemical toxicology of cadmium. Fed Proc. 1976; 35(1): 75-80.
• 14. Petersson-Grawe K, Teiling-Gardlund A, Jalkesten E, et al. Increased spontaneous motor activity in offspring after maternal cadmiumexposure during lactation. Environ Toxicol Pharmacol. 2004; 17(1):35-43.
• 15. Salehi B, Imani R, Mohammadi MR. Ginko biloba for Attention-Deficit/Hyperactivity Disorder in children and adolescents: A double blind,randomized controlled trial. Progress in Neuro-Psychopharmacology& Biological Psychiatry 2010; 76-80.
• 16. Canfield RL, Henderson CR Jr, Cory-Slechta DA, et al. Intellectual impairment in children with blood lead concentrations below 10 microgper decitier. N Engl J Med. 2003; 348: 1517-26.
• 17. Bellinger DC. Lead. Pediatrics 2004; 113(4): 1016-1022.
• 18. Koller K, Brown T, Spurgeon A, et al. Recent developments in low-level lead exposure and intellectual impairment in children. Environ Health Perspect. 2004; 112(9): 987-994.
• 19. Lidsky TI, Schneider JS. Lead neurotoxicity in children: Basic mechanisms and clinical correlates. Brain 2003; 126: 5-19.
• 20. Needleman HL. Lead poisoning. Ann Rev Med. 2004; 55: 209-222.
• 21. Landrigan PJ, Carlson JE, Bearer CF, et al. Children’s health and the environment: a new agenda for prevention research. Environ. Health Persp. 1998; 106(3): 787-794.
• 22. Juberg DR, Kleiman CF, Kwon SC. Position paper of the American Council on Science and Health: lead and human health. EcotoxicolEnviron Saf. 1997; 38: 162-80.
• 23. Wakefield J. The load effect? Environ Health Persp. 2002; 110: 574-80.
• 24. Goldberg A. Review of recent advances of lead in clinical research. Postgraduate Med J. 1975; 51: 747-750.
• 25. Brody DJ, Pirkle JL, Kramer RA, et al. Blood lead levels in the US population. Phase 1 of the Third National Health and NutritionExamination Survey (NHANES III, 1988 to 1991). JAMA 1994; 272:277-83.
• 26. Canfield RL, Kreher DA, Cornwell C, et al. Low-level lead exposure, executive functioning, and learning in early childhood. Child Neuropsychol. 2003; 9: 35-43.
• 27. Braun JB, Kahn RS, Froehlich T, et al. Exposures to Environmental Toxicants and Attention Deficit Hyperactivity Disorder in U.S.Children. Environ Health Perspect. 2006; 114: 1904-1909.
• 28. Fido A, Al-Saad S. Toxic trace elements in the hair of children with autism. Autism 2005; 9: 290-298.
• 29. Tuthill RW. Hair lead levels related to children’s classroom attentiondeficit behavior. Arch Environ Heath. 1996; 5(3): 214-220.
• 30. Nigg JT, Knottnerus GM, Martel MM, et al. Low Blood Lead Levels Associated with Clinically Diagnosed Attention-Deficit/HyperactivityDisorder and Mediated by Weak Cognitive Control. Biol Psychiatry2008; 61(3): 325-331.
• 31. Braun JM, Kahn RS, Froehlich T, et al. Exposures to environmental toxicants and attention deficit hyperactivity disorder in US children.Environ Health Perspect 2006; 114: 1904-1909..
• 32. Surkan PJ, Zhang A, Trachtenberg F, et al. Neuropsychological function in children with blood lead levels < 10 μg/dL. Neurotoxicology 2007;28(6): 1170-1177.
• 33. Kozielec T, Kedzierska E, Graczyk A and al. The content of lead, cadmium and some other bioelements in children residing in andaround Szczecin. in: Dziecko w środowisku zagrożonym ekologicznie.Materiały IX Konferencji Naukowej, Legnica 2-3 June 2000: 37.
• 34. Kędzierska K. Concentrations of some bioelements and toxic metals and their influence on health of children and youth residing in Szczecin.Ann Acad Med Stetin. 2003; 49: 31-143.
• 35. Nordberg GF, Nogawa K, Nordberg M, et al. Cadmium. In Handbook on The Toxicology of Metals 2007; 445-486.
• 36. Cao Y, Chen A, Radcliffe J. Postnatal cadmium exposure,neurodevelopment, and blood pressure in children at 2, 5, and 7 yearsof age. Environmental Health Perpectives 2009; 117(10): 1580-1586.
• 37. Jiang HM, Han GA, He ZL. Clinical significance of hair cadmium content in the diagnosis of mental retardation of children. Chin Med J.1990; 103(4), 331-334.
• 38. Capel ID, Pinnock MH, Dorrell HM, et al. Comparison of concentrations of some trace, bulk, and toxic metals in the hair of normal and dyslexicchildren. Clin Chem. 1981; 27(6): 879-881.
• 39. Thatcher RW, Lester ML, McAlaster R, et al. Effects of low levels of cadmium and lead on cognitive functioning in children. Arch EnvironHealth. 1982; 37(3): 159-166.
• 40. Moon C, Marlowe M, Stellern J, et al. Main and interaction effects of metallic pollutants on cognitive functioning. J Learn Disabil. 1985;18(4), 217-221.
• 41. Pihl RO, Parkes M. Hair element content in learning disabled children. Science. 1977; 198(4313): 204-206.
• 42. Thatcher RW, Lester ML, McAlaster R, et al. Effects of low levels of cadmium and lead on cognitive functioning in children. Arch EnvironHealth. 1982; 37(3): 159-166.

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