Changes of brain-derived neurotrophic factor (BDNF) immunoreactive cells number in hypothalamic nuclei after chronic stress young and aged rats

• Autorzy: Cecot T. , Badowska E. , Klejbor I. , Domaradzka-Pytel B. , Morys J.
• Języki publikacji: EN

Abstrakty

EN

It is postulated, that brain-derived neurotrophic factor (BDNF) have been implicated in the neurobiological mechanisms underlying brain plasticity after chronic stress. The objective of this study was to evaluate infl uence of chronic stress on brain plasticity measured by BDNF immunoreactivity in brain structures of young (P28) and adult (P360) rats. 26 male Wistar rats were exposed to 15 min daily open fi eld (OF) or forced swim test (FS) during three weeks. Fluorescent immunohistochemistry was used to localize BDNF positive cells in hypothalamic areas connected with stress response: both parvo- and magnocellular divisions of the paraventricular nucleus (PVp and PVm) and the supraoptic nucleus (SO). In animals aged P28 chronic OF i FS stress caused a statistically signifi cant (P<0.001) decline in the number of BDNF-ir cells in both parts of the PV and SO. In contrast, in rats P360 was not observed any change in the number of BDNF-ir cells after chronic OF stimulation compared to control in PVp and SO. In summary: age of rats subjected to chronic stimulation OF FS or stress had an impact on changes in the number of BDNF-ir cells in the tested hypothalamic nuclei.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.363

Twórcy

autor

Cecot T.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Badowska E.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Klejbor I.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Domaradzka-Pytel B.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Morys J.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland