Posterior hypothalamic theta rhythm and local cell discharges in adult anesthetized rats

• Autorzy: Bocian R. , Klos-Wojtczak P. , Caban B. , Kowalczyk T. , Kazmierska P. , Konopacki J.
• Języki publikacji: EN

Abstrakty

EN

BACKGROUND AND AIMS: Theta rhythm is the best synchronized electroencephalographic activity that can be recorded in several brain regions, for example, in the cingulate cortex, entorhinal cortex, and hippocampal formation (HPC) that is considered to be the main structure involved in the generation of theta. Just recently Kowalczyk et al. (2014) have indicated that this pattern EEG could also be observed in the posterior hypothalamic area (HPa) in anesthetized rats. Specifically, in the supramammillary (SuM) and posterior hypothalamic (PH) nuclei theta field activity was produced independently of simultaneously occurring hippocampal theta. Previous experiments have demonstrated that the HPC theta field activity is accompanied by a characteristic pattern of local cell discharges. PHa cells discharges were classified in accordance to earlier developed classification as theta-related and theta-nonrelated. Theta-related cells were classified as theta-on and theta-off. Both theta-on and theta-off cells were subclassified as phasic and tonic. The aim of the present studies was to describe firing cell repertoire during cholinergically induced theta rhythm in the PHa of rats. METHODS: All the experiments were performed in urethanized adult male Wistar rats. PHa theta rhythm and single cell activity were recorded with use of tungsten and glass microelectrodes respectively. RESULTS: One hundred fifty five out of 236 recorded in PHa cells were identified as theta non-related cells and 82 as theta-related cells: 48 theta-on, 29 theta-off, and 4 theta gating cells (the cells which activity is correlated with appearance of theta episodes). CONCLUSION: The obtained data clearly demonstrates that cholinergically induced theta activity in PHa, similarly to the HPC theta, is accompanied by local cell discharges which can be successfully classified in accordance with earlier developed criteria for HPC theta. The study was supported by National Science Centre (NCN, 2013/11/B/NZ4/04872).

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S62

Twórcy

autor

Bocian R.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Klos-Wojtczak P.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Caban B.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Kowalczyk T.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Kazmierska P.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Konopacki J.

• Department of Neurobiology, University of Lodz, Lodz, Poland