Thirty-thousand-year-old DNA virus with a pandoravirus morphology isolated from Siberian permafrost. Possible link of swine flu vaccination with narcolepsy. Novel synthetic broad-spectrum nucleoside analogue BCX4430 protects against filovirus disease in cynomolgus macaques. It also exhibited in vitro antiviral activity against negative-sense and positive-sense RNA viruses. Maternal retinoids control the offspring immunity. The mother is responsible for both the absorbion of vitamin A from food and its conversion to retinoic acid. Novel and life-threatening immunodeficiency characterized by impaired capacity of activated T and B cells to proliferate in response to antigen receptor-mediated activation. Key and specific role of CTPS1 to sustain the proliferation of activated lymphocytes. 2013 year marks a turning point in cancer immunoterapy.
1. Cousin-Frankel J.: Cancer immunoterapy. Science 2013, 342, 1432-1433.
2. Eberl G.: A is for immunity. Nature 2014, 508, 47-48.
3. Kaiser J.: Antioxidants could spur tumors by acting on cancer gene. Science 2014, 343, 477.
4. Legendre M., Bartoli J., Shmakova L., Jeudi S., Labadie K., Adrait A., Lescot M., Poirot O., Bertaux L., Bruley C., Coute Y., Rivkina E., Abergel C.,Claverie J.-M.: Thirty-thousand-year-old icosahedral DNA viruses witha pandoravirus morphology. Proc. Natl. Acad. Sci. 2014, 111, 4274-4279.
5. Martin E., Palmic N., Sanquer S., Lenoir C., Hauck F., Mongellaz C., Fabrega S., Nitschke P., Esposti M. D., Schwartzentruber J., Taylor N., Majewski J., Jabado N., Wynn R. F., Picard C., Fischer A., Arkwright P. D., Latour S.: CTP synthase 1 deficiency in humant revealds its central role in lymphocyte proliferation. Nature 2014, 510, 288-292.
6. Panchal R. G., Kota K. P., Spurgers K. B., Ruthel G., Tran J. P., Boltz R. C., Bavari S.: Development of High-Content imaging assays for lethal pathogens.J. Biomol. Screen. 2010, 15, 755-765.
7. Pavert van de S. A., Ferreira M., Domingues R. G., Riberino H., Molenaar R., Moreira-Santos L., Almeida F. F., Ibiza S., Barbosa I., Goverse G., Labado- -Almeida C., Goginho-Silva C., Konijn T., Schooneman D., O’Toole T., Mizee M. R., Habani Y., Haak E., Santori F. R., Litman D. R., Schulte-Merker S., Dzierzak E., Simas J. P., Mebius R. E., Veiga-Fernandes H.: Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature 2014, 508, 123-127.
8. Veilette A., Davidson D.: When lymphocytes run out of steam. Nature 2014, 510, 222-223.
10. Warren T. K., Wells J., Panchal R. G., Stuthman K. S., Garza N. L., Van Tongeren S. A., Dong L., Retterer C. J., Eaton B. P., Pegoraro G., Honnold S., Bantia S., Kotian P., Chen X., Taubenheim B. R., Welch L. S., Minning D. M., Bau Y. S., Sheridan W. P., Bavari S.: Protection against filovirus diseases by novel broad-spectrum nucleoside analogue BCX4430. Nature 2014, 508,402-405.